Abstract:
An oligomer probe array is provided to improve focusing efficiency at exposure by using near-infrared rays having lower energy intensity than ultraviolet rays as exposure source, and form nano probe cell actives, so that it is useful for the microarray and high integration of oligomer probe array. An oligomer probe array comprises: a substrate; an oligomer probe on the substrate; and an active membrane formed as a polymer containing a monomer having a two-photon absorption group, a monomer having a photo-crosslinking functional group and a monomer having a function group capable of coupling with the oligomer probe directly or indirectly, wherein the photo-crosslinking functional group is cinnamoyl group; and the polymer is represented by the formula in which X is a group represented by the structure of an electron donor or electron acceptor-pi electron center-electron donor or electron acceptor, Y is hydroxyl group, aldehyde group, carboxyl group, amino group, amide group, thiol group, halo group or sulfonate group, R1 is hydrogen or C1-4 alkyl group, R2 is C1-4 alkylene group, C1-4 alkoxy group or phenylene group, R3 is C1-8 alkylene group or C1-8 alkoxy group, R4 is hydrogen or methyl group. Further, the active membrane is separated into a plurality of probe cell actives.
Abstract:
A nonlinear silicone compound, a method for preparing an oligomer probe array by using the compound, and an oligomer probe array prepared by the method are provided to reduce the effect of a solvent in case of sol-gel reaction, thereby decreasing self-aggregation and increasing fluorescence intensity. A nonlinear silicone compound is represented by the formula, wherein A is a specific aromatic group or an aromatic group protected with a photolabile group or an acid-labile group; R1, R2 and R3 are H, CH3, -OCH3 or a halogen atom but at least one of them is CH3, -OCH3 or a halogen atom; l is 2-10; and m is 1-5. An oligomer probe array is prepared by providing a substrate; forming an active layer on the substrate; and forming a silicone compound layer on the substrate by using the silicone compound of the formula.
Abstract:
다채널 형광 검출 모듈 및 이를 포함하는 핵산 분석 시스템이 개시된다. 일 실시예에 따른 핵산 분석 시스템은, 미세 유체 소자를 포함하는 다수의 카트리지들이 각각 배치될 수 있는 다수의 적재부; 직선 운동을 하는 가동자를 구비하는 리니어 액추에이터를 포함하는 이송 모듈; 및 상기 가동자에 고정되어 상기 가동자와 함께 이동하는 것으로, 상기 카트리지에 여기광을 조사하고 상기 카트리지 내의 샘플로부터 발생한 형광을 검출하는 형광 검출 모듈;을 포함하며, 상기 다수의 적재부들은 상기 가동자의 직선 운동 궤도를 따라 일렬로 배열될 수 있다.
Abstract:
PURPOSE: An optical scanner revising element, a manufacturing method thereof, and a method for revising the optical scanner by using the same are provided to variously measure pixels of an optical scanner and to form various patterns. CONSTITUTION: An optical scanner revising element comprises a substrate(10) and a pattern(20). The same pattern is located on the top of the substrate. The same pattern is made of photoresist. The photoresist is the color photoresist. The substrate is made of one of silicon, quartz, glass and plastic materials. Multiple patterns are arranged on the top of the substrate as an array shape. A marginal region(27) is included between multiple patterns. Photoresist comprises a photoresist bonding agent, and pigment or dye.
Abstract:
PURPOSE: A microarray probe synthesis apparatus having a capillary nozzle is provided to effectively synthesize microarray probes. CONSTITUTION: A microarray probe synthesis apparatus(1) comprises: a fixing part(10) for fixing a substrate; and a liquid sprayer(30) having a capillary nozzle(300) and a support(310). The surface(312) of the support is separated from the fixing part and is movably placed to the top or bottom. A liquid container contains a solution containing biochemical substances necessary for a microarray probe synthesis. The biochemical substance is a nucleotide or peptide molecule. The capillary nozzle is made of glass, quartz, Teflon, and chemical resistant polymer.
Abstract:
A method for preparing a polymer array and a method for cutting a photolabile protecting group are provided to effectively manufacture a polymer array with less exposure energy by photolithography. A method for preparing a polymer array comprises the steps of: (i) reacting a monomer containing a photolabile protecting group on the surface of a substrate, and fixing the monomer on the substrate; (ii) coating the surface fixed with the monomer with the solution containing a photosensitive material and coating material; (iii) cutting the photolabile protecting group from the monomer by performing selectively electromagnetic irradiation to specific site on the surface of the substrate coated with the photosensitive material and coating material; (iv) exposing the monomer cut with the photolabile protecting group by electromagnetic irradiation of (iii) step; (v) reacting the monomer cut with the photolabile protecting group and the monomer containing the photolabile protecting group and connecting them; and (vi) repeating the (ii) ~ (v) step.
Abstract:
프로브를 이용하여 바이오 시료의 성분을 분석하는 바이오칩 및 그 제조 방법이 제공된다. 바이오칩은 기판, 기판 상면을 부분적으로 덮는 캡핑막 패턴, 및 캡핑막 패턴에 의해 노출된 기판 상면 상에 커플링된 복수의 프로브를 포함한다. 프로브, 캡핑막 패턴, 비프로브 셀 영역
Abstract:
반응 수율이 향상되고, 프로브와 표적 물질의 혼성화 반응에 의한 혼성화 시그널의 검출 감도를 높일 수 있는 올리고머 프로브 어레이가 제공된다. 올리고머 프로브 어레이는 기판, 기판상의 고정화층, 고정화층에 커플링되고 광결정 구조를 형성하는 나노 입자 및 나노 입자와 커플링된 올리고머 프로브를 포함하되, 고정화층은 나노 입자가 커플링되는 다수의 프로브 셀 영역을 포함하고, 프로브 셀 영역은 프로브 셀 분리 영역에 의해 분리된다. 올리고머 프로브 어레이, 광결정구조, 형광물질, 프로브