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公开(公告)号：KR1020130124065A
公开(公告)日：2013-11-13
申请号：KR1020120047683
申请日：2012-05-04
Applicant: 삼성전자주식회사 , 성균관대학교산학협력단
CPC classification number: Y02E50/17 , C12N15/815 , C12N9/2402 , C12P7/10 , C12P7/40 , C12P13/04 , C12P19/02 , C12P19/04
Abstract: Disclosed is modified microorganisms for simultaneous saccharification and fermentation, an expression vector for preparing the modified microorganisms, and a method for producing chemical materials using the modified microorganisms. According to one side, disclosed is modified Kluyveromyces marxianus which produces chemical materials by simultaneous saccharification and fermentation and contains a replication origin; a promoter; a gene encodes one or more cellulose decomposing enzymes selected among beta-glucosidase, endoglucanase, exoglucanase, and cellobiohydrolase; and a terminator.
Abstract translation: 公开了用于同时糖化和发酵的改性微生物，用于制备改性微生物的表达载体，以及使用改性微生物生产化学物质的方法。 一方面，公开了通过同时进行糖化和发酵生产化学物质的马克斯克鲁维酵母（Kluyveromyces marxianus），并含有复制起点; 启动子 一种基因编码一种或多种选自β-葡糖苷酶，内切葡聚糖酶，外切葡聚糖酶和纤维二糖水解酶的纤维素分解酶; 和终结者。
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公开(公告)号：KR1020130097628A
公开(公告)日：2013-09-03
申请号：KR1020120125519
申请日：2012-11-07
Applicant: 성균관대학교산학협력단
IPC: C07K14/775 , A61K47/42 , A61K9/10
CPC classification number: C07K14/775 , A61K9/10 , A61K47/42
Abstract: PURPOSE: An antibody-drug conjugate (ADC) is provided to show superior treatment effect compared with an existing conjugate because large drugs are conjugated to antibodies. CONSTITUTION: A lipoprotein variant is able to encapsulate a drug and has a hydrophilic region in which one or more amino acid residues are substituted with cysteine. The hydrophilic region is exposed to the outside of the lipoprotein when the drug is encapsulated. A nanostructure is prepared by encapsulating the drug in a three-dimensional structure of the variant lipoprotein. An ADC has lipoprotein and an antibody which are linked directly or by a linker and contains the drug encapsulated in the three-dimensional structure of isolated lipoprotein.
Abstract translation: 目的：提供抗体 - 药物偶联物（ADC）以显示与现有缀合物相比优异的治疗效果，因为大量药物与抗体结合。 构成：脂蛋白变体能够包封药物并且具有其中一个或多个氨基酸残基被半胱氨酸取代的亲水区域。 当药物被包封时，亲水区域暴露于脂蛋白的外部。 通过将药物包封在变体脂蛋白的三维结构中来制备纳米结构。 ADC具有直接或通过接头连接的脂蛋白和抗体，并且包含封装在分离的脂蛋白的三维结构中的药物。
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公开(公告)号：KR101303383B1
公开(公告)日：2013-09-03
申请号：KR1020120100118
申请日：2012-09-10
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 일본잎갈나무(
Larix
leptolepis ), 다릅나무(
Maackia
amurensis ), 산괴불주머니(Corydalis speciosa), 짚신나물(
Agrimonia
pilosa ), 만삼(
Codonopsis
pilosula ), 버드나무(
Salix
koreensis ), 산가막살나무 (
Viburnum
wrightii ), 굴피나무(
Platycarya
strobilacea ), 족제비싸리(
Amorpha
fruticosa ), 돌배나무(
Pyrus
pyrifolia ), 비수리(
Lespedeza
cuneata ), 물양지꽃(
Potentilla
cryptotaeniae ), 및 눈갯버들(
Salix graciliglans )로 이루어진 군으로부터 선택된 하나 이상의 추출물을 포함하는 비만세포의 과립 분비 억제용 조성물에 관한 것으로 이 조성물은 알레르기성 질환의 예방, 개선, 치료에 효과적이므로 알레르기성 질환의 개선, 예방 또는 치료용 약제학적 조성물, 식품 조성물, 의약외품 조성물, 및 화장료 조성물 등으로 사용될 수 있다.-
公开(公告)号：KR101131202B1
公开(公告)日：2012-04-05
申请号：KR1020100016400
申请日：2010-02-23
Applicant: 성균관대학교산학협력단 , (주)에이피테크놀로지
IPC: A61K9/127 , A61K31/122 , A61K31/575 , A61K47/48
CPC classification number: A61K9/1275
Abstract: 본 발명은 난용성 약물을 가용화할 수 있는 난용성 약물 나노복합체의 제조방법을 제공하는 것이며, 구체적으로 본 발명은 난용성 약물 및 아포리포단백질의 나노복합체를 높은 수율로 제조할 수 있는 제조방법을 제공한다.
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公开(公告)号：KR1020110122012A
公开(公告)日：2011-11-09
申请号：KR1020100041570
申请日：2010-05-03
Applicant: 삼성전자주식회사 , 성균관대학교산학협력단
CPC classification number: Y02E50/17 , C12P7/06 , C12N15/81 , C12R1/865 , Y10S435/942
Abstract: PURPOSE: A recombinant strain containing truncated Tup1 polypeptide and a composition containing the same for producing alcohol are provided to improve alcohol resistance and to ensure alcohol productivity. CONSTITUTION: A recombinant strain contains first polypeptides having the function of an expression inhibition domain is truncated from Tup1 and a second polypeptide in which Ino1 is expressed. The first polypeptide contains amino acid sequence in which one or more among 288-389th amino acids are substituted, inserted, added or truncated. The second polypeptide has an amino acid sequence having 70% or more sequence homology with an amino acid of sequence number 2. The carboxyl terminal end domain is a truncated Tup1 polypeptide. A composition for producing alcohol contains the recombinant strand.
Abstract translation: 目的：提供含有截短的Tup1多肽的重组菌株和含有其的用于生产醇的组合物以改善耐酒精性并确保酒精生产率。 构成：重组菌株含有具有表达抑制结构域的功能的第一多肽从Tup1截短，其中表达有Ino1的第二多肽。 第一多肽含有氨基酸序列，其中288-389位氨基酸中的一个或多个被取代，插入，添加或截短。 第二多肽具有与序列号2的氨基酸具有70％以上序列同源性的氨基酸序列。羧基末端结构域是截短的Tup1多肽。 用于生产醇的组合物含有重组链。
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Patent Agency Ranking36.发明授权
公开(公告)号：KR100991486B1
公开(公告)日：2010-11-04
申请号：KR1020080098801
申请日：2008-10-08
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 고체 표면과 결합력을 가진 아미노산의 서열로 N-말단과 C-말단 중 어느 하나 또는 양쪽 모두가 신장(elongation)된 아포리포프로테인(apolipoprotein) A-Ⅰ이 인지질(phospholipid)을 둘러 감싸 형성된 막 구조체의 내부에 막 단백질을 포집시켜 고체 표면에 고정화시키는 것을 특징으로 하는 막 단백질의 고체 표면 고정화 방법에 관한 것으로, 막 단백질의 고용량 스크리닝을 목적으로 하는 칩 기반 어레이(chip-based array) 기술에서 막 단백질의 광범위한 스크리닝을 위해 사용될 수 있다.
apoA-Ⅰ, SAMPAM, Ni-NTA, 고정화, 나노디스크, 단백질, 막, 인지질, 칩, 태그-
公开(公告)号：KR100913917B1
公开(公告)日：2009-08-26
申请号：KR1020080083883
申请日：2008-08-27
Applicant: 성균관대학교산학협력단
Abstract: 본 발명은 천연물 추출물을 유효성분으로 포함하는 신경전달물질 배출 조절용 조성물에 관한 것이다. 본 발명의 조성물은 SNARE 복합체 형성의 저해제로서 신경전달물질 배출을 조절함으로써 SNARE가 관여하는 세포내 반응의 조절제로 유용하다. 본 발명의 SNARE 복합체 형성 저해제는 피부 통증 완화용 조성물로 활용될 수 있다.
천연물 추출물, SNARE, 신경전달물질, 막융합-
公开(公告)号：KR1020080082955A
公开(公告)日：2008-09-12
申请号：KR1020080083883
申请日：2008-08-27
Applicant: 성균관대학교산학협력단
Abstract: A composition is provided to be useful as an inhibitor of SNARE(soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex formation by controlling release of a neurotransmitter, thereby being applicable as a pain alleviating composition. A composition for mitigating pain comprises 0.001-50 wt.% of an extract of one natural material selected from the group consisting of leaves, flowers and stems of Carpinus tschonoskii; spikes of Platycarya strobilacea and Meliosma myriantha; aerial whole plants of Sedum kamtschaticum and Potentilla cryptotaeniae; stems of Euscaphis japonica and Juglans sinensis; roots of Boehmeria nivea; leaves of Schizophragma; flowers of Castanea crenata; and leaves and stems of Maackia amurensis, Elaeagnus umbellata, Rhus chinensis, Lindera erythrocarpa, Rubus crataegifolius, Cornus kousa, and Robinia pseudo-accacia, and a pharmaceutically acceptable carrier, diluent or excipient.
Abstract translation: 通过控制神经递质的释放，提供了可用作SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）复合体形成抑制剂的组合物，因此可用作疼痛缓解组合物。 用于减轻疼痛的组合物包含0.001-50重量％的选自由Carpinus tschonoskii的叶，花和茎的一种天然材料的提取物; Platycarya strobilacea和Meliosma myriantha的尖峰; 天竺葵um;;;;;;;;;;;;;;;;;;;; E草和胡桃茎; Boehmeria nivea的根; Sch Cast藜花; 以及马鞭草，叶桉，中华ensis，林era，红，，ia ia和假and and的叶和茎以及药学上可接受的载体，稀释剂或赋形剂。
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公开(公告)号：KR1020080056576A
公开(公告)日：2008-06-23
申请号：KR1020060129644
申请日：2006-12-18
Applicant: 성균관대학교산학협력단
CPC classification number: A61K36/52 , A61K36/41 , A61K36/48 , A61K2236/33 , A61K2236/51 , A61Q19/08
Abstract: A composition comprising an extract of natural materials is provided to be useful as a controlling agent of intracellular reaction with which SNARE(soluble N-ethylmaleimide-sensitive factor attachment protein receptor) is involved by controlling release of neurotransmitter and be applied as a composition for improving wrinkles and alleviating pains. A composition for inhibiting SNARE comprises an extract extracted from at least one natural materials selected from the group consisting of Carpinus tschonoskii, Platycarya strobilacea, Sedum kamtschaticum, Meliosma myriantha, Maackia amurensis, Euscaphis japonica, Boehmeria nivea, Potentilla cryptotaeniae, Schizophragma hydrangeoides, Castanea crenata, Elaeagnus umbellata, Rubus coreanus, Rhus chinensis, Lindera erythrocarpa, Rubus crataegifolius, Cornus kousa, Robinia pseudo-acacia and Juglans sinensis, a pharmaceutically acceptable carrier, a diluent or an excipient. A method for extracting the extract from the natural materials comprises the steps of: (a) crushing the natural materials; (b) extracting the crushed material with methanol, ethanol or water and freeze-drying the extract; and (c) dissolving a material obtained from the step(b) in water.
Abstract translation: 提供包含天然物质提取物的组合物，可用作通过控制神经递质的释放而涉及SNARE（可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体）的细胞内反应的控制剂，并用作改善用组合物 皱纹和缓解疼痛。 用于抑制SNARE的组合物包含从至少一种天然材料提取的提取物，所述天然材料选自Carpinus tschonoskii，野菜，Sedum kamtschaticum，Meliosma myriantha，Maackia amurensis，Euscaphis japonica，Boehmeria nivea，Potentilla cryptotaeniae，Schizophragma cavrangeoides，Castanea crenata ，榆树（Elaeagnus umbellata），红钩虫属（Rubus coreanus），中华ensis ensis（Rhus chinensis），枸杞（Lindera erythrocarpa），红钩虫（Rubus crataegifolius），萸，属（Cornus kousa），刺槐拟拟相思和胡桃木胡椒（Juglans sinensis），药学上可接受的载体，稀释剂或赋形剂。 从天然材料中提取提取物的方法包括以下步骤：（a）粉碎天然材料; （b）用甲醇，乙醇或水萃取破碎的物料，冷冻干燥; 和（c）将从步骤（b）获得的材料溶于水中。
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