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公开(公告)号：KR1020090004027A
公开(公告)日：2009-01-12
申请号：KR1020070067907
申请日：2007-07-06
Applicant: 한국과학기술연구원
CPC classification number: B29C70/32 , A61F2/06 , A61F2210/0004 , D01D5/0007 , D01D5/04
Abstract: A manufacturing method of a tube type porous scaffold of a double-film structure for artificial blood vessel is provided to have excellent interconnectivity between air bubbles, mechanical stability, transfection and breeding efficiency and to prevent fistula blood at the hypertension state. A manufacturing method of a tube type porous scaffold of a double-film structure for artificial blood vessel comprises steps of: dissolving biodegradable polymer in organic solvent and mixing porogen and manufacturing a polymer/porogen mixed solution; coating a cylindrical shaft with polymer/porogen mixed solution and forming an inner film of a porous coating layer; dissolving the biodegradable polymer in the organic solvent and manufacturing a biodegradable polymer gel; dipping the cylindrical shaft forming the inner film of the porous coating layer, rotating it, falling and radiating the biodegradable polymer gel, winding fiber of a gel state to the inner film of the porous coating layer and forming an outer film of a polymeric fiber layer; separating porosity scaffold of the double-film structure formed in a shaft and removing the organic solvent and the porogen.
Abstract translation: 提供了一种用于人造血管的双层膜结构的管型多孔支架的制造方法，其具有优异的气泡互连性，机械稳定性，转染和繁殖效率，并防止瘘血在高血压状态。 一种用于人造血管的双层膜结构的管型多孔支架的制造方法，包括以下步骤：将可生物降解的聚合物溶解在有机溶剂中并混合致孔剂并制备聚合物/致孔剂混合溶液; 用聚合物/致孔剂混合溶液涂覆圆柱形轴并形成多孔涂层的内膜; 将可生物降解的聚合物溶解在有机溶剂中并制造可生物降解的聚合物凝胶; 浸渍形成多孔涂层的内膜的圆柱形轴，旋转，将可生物降解的聚合物凝胶落下并辐射凝胶状态的卷绕纤维到多孔涂层的内膜，并形成聚合物纤维层的外膜 ; 分离形成在轴中的双膜结构的孔隙支架，并除去有机溶剂和致孔剂。
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公开(公告)号：KR100803057B1
公开(公告)日：2008-02-18
申请号：KR1020060108424
申请日：2006-11-03
Applicant: 한국과학기술연구원
IPC: B01J27/053 , B01J27/14 , B01J21/00
CPC classification number: B01J27/053 , B01J27/14 , B01J35/02 , B01J37/08
Abstract: A solid acid catalyst for decomposing methanol and a method for producing the same are provided to suppress the generation of by products and prevent the reduction of hydrogen due to a methanation reaction between hydrogen and carbon monoxide. A solid acid catalyst is produced by hardening a mixture in which one or more kinds of solid acid are mixed. The solid acid is selected from kaolinite, bentonite, attapulgite, zeolite, montmorillonite, ZnO, Al2O3, TiO2, CeO2, V2O5, SiO2, Cr2O3, CaSO4, MnSO4, NiSO4, CuSO4, CoSO4, CdSO4, MgSO4, FeSO4, Al2(SO4)3, ZnSO4, Ca(NO3)2, Zn(NO3)2, Fe(NO3)3, AlPO4, FePO4, CrPO4, Cu3(PO4)2, Zn3(PO4)4, Mg3(PO4)2, AlCl3, TiCl4, CaCl2, AgCl, CaF2, and BaF2. Further, the solid acid is mixed with a sulphuric acid or a phosphoric acid, and plasticized.
Abstract translation: 提供用于分解甲醇的固体酸催化剂及其制备方法，以抑制副产物的产生并防止氢气和一氧化碳之间的甲烷化反应引起的氢气还原。 通过使混合有一种或多种固体酸的混合物硬化来制备固体酸催化剂。 固体酸选自高岭石，膨润土，绿坡缕石，沸石，蒙脱石，ZnO，Al2O3，TiO2，CeO2，V2O5，SiO2，Cr2O3，CaSO4，MnSO4，NiSO4，CuSO4，CoSO4，CdSO4，MgSO4，FeSO4，Al2（SO4） 3，ZnSO 4，Ca（NO 3）2，Zn（NO 3）2，Fe（NO 3）3，AlPO 4，FePO 4，CrPO 4，Cu 3（PO 4）2，Zn 3（PO 4）4，Mg 3（PO 4）2，AlCl 3，TiCl 4， CaCl 2，AgCl，CaF 2和BaF 2。 此外，将固体酸与硫酸或磷酸混合并增塑。
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公开(公告)号：KR100737167B1
公开(公告)日：2007-07-10
申请号：KR1020060054236
申请日：2006-06-16
Applicant: 한국과학기술연구원
Abstract: Provided is a porous osteochondral composite scaffold with layer structure which has features of bioactivation and mechanical strength suitable to regenerate cartilage and bone simultaneously and method for manufacturing the same. The porous osteochondral composite scaffold comprises: a porous bone regeneration layer which includes biocompatable high molecule and bioactivation ceramic; a porous cartilage regeneration layer which includes biocompatable elastic high molocule. The method for manufacturing a porous osteochondral composite scaffold comprises the steps of: mixing biocompatable high molecule, bioactivation ceramic and lacuna-forming material; press-forming the mixed material from the first step in a mold; bonding the obtained material from the second step by heating to form a porous bone regeneration layer; forming composite material by press-forming gelled mixed material for forming cartilage which dissolves in solution with biocompatable high molecule and lacuna-forming material on one surface of the regenerated layer from the third step; removing solution and lacuna-forming material in the composite material from the fourth step.
Abstract translation: 本发明提供一种具有适于同时再生软骨和骨的具有生物活化和机械强度特征的层状结构的多孔骨软骨复合支架及其制造方法。 多孔骨软骨复合支架包括：多孔骨再生层，其包含生物相容性高分子和生物活化陶瓷; 包含生物相容性弹性高分子量多孔体的多孔软骨再生层。 制备多孔骨软骨复合支架的方法包括以下步骤：混合生物相容性高分子，生物活化陶瓷和腔隙形成材料; 在模具中将来自第一步骤的混合材料压制成形; 通过加热将来自第二步骤的所得材料结合以形成多孔骨再生层; 通过在第三步骤的再生层的一个表面上通过压制成型用于形成软骨的凝胶化混合材料形成复合材料，所述软骨溶解于具有生物相容性高分子和空腔形成材料的溶液中; 从第四步移除复合材料中的溶液和空穴形成材料。
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公开(公告)号：KR1020070006551A
公开(公告)日：2007-01-11
申请号：KR1020060034400
申请日：2006-04-17
Applicant: 한국과학기술연구원
Abstract: A method of preparing porous polymer is provided to improve a cell seeding efficiency by a uniform size of a gap and excellent interconnectedness between gaps, and to prepare simply porous polymer scaffold appropriate for a tissue engineering by an excellent mechanical strength. The method comprises the steps of: manufacturing polymer solution by melting biocompatible polymers in organic solvents; forming polymer gel from non-solvent solutions by spinning the polymer solution obtained in the pre-step to non-solvent stirred by a rotating shaft; forming porous polymer scaffold by making the polymer gel formed in the pre-step wound on the rotating shaft; and removing the organic solvents by drying the porous polymer scaffold obtained in the pre-step.
Abstract translation: 提供一种制备多孔聚合物的方法，以通过间隙的均匀尺寸和间隙之间的优异相互连接来改善细胞接种效率，并且通过优异的机械强度制备适于组织工程的简单多孔聚合物支架。 该方法包括以下步骤：通过在有机溶剂中熔融生物相容性聚合物制备聚合物溶液; 通过将在前步骤中获得的聚合物溶液旋转到通过旋转轴搅拌的非溶剂，从非溶剂溶液形成聚合物凝胶; 通过使前述步骤中形成的聚合物凝胶在旋转轴上形成多孔聚合物支架; 并通过干燥在前步骤中获得的多孔聚合物支架来除去有机溶剂。
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公开(公告)号：KR100590137B1
公开(公告)日：2006-06-15
申请号：KR1020030002289
申请日：2003-01-14
Applicant: 한국과학기술연구원
IPC: C07C309/21
Abstract: 본 발명은 술폰산화 폴리에틸렌옥시드(PEO, poly(ethylene oxide))를 함유하는 비닐 단량체와 그 중합체 및 그들의 제조 방법에 관한 것이다.
본 발명의 단량체로 이루어진 중합체 및 표면 그라프트 개질체는 항혈전성이 우수하므로 혈액과 접촉되는 의료용 소재로 응용할 수 있다.
술폰산화 PEO 함유 비닐 단량체, 항혈전성 중합체, 의료용 재료-
Patent Agency Ranking
公开(公告)号：KR100517097B1
公开(公告)日：2005-09-27
申请号：KR1020020084892
申请日：2002-12-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: 본 발명은 뛰어난 유연성 및 적당한 가수분해성을 가진 생분해성 고분자 및 이 중합체로부터 형성된 다공성 지지체에 관한 것이다. 더욱 상세히 말하자면, 본 발명은 생분해성 재료인 락타이드와 ε-카프로락톤을 이용하여 중량 평균 분자량이 10,000 이상인 락타이드/ε-카프로락톤의 생분해성 공중합체를 제조하고, 이를 이용하여 상처피복재, 세포 배양용 지지체 재료로 사용 가능한 다공성 지지체 제조에 관한 것이다.
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37.发明公开
公开(公告)号：KR1020040058572A
公开(公告)日：2004-07-05
申请号：KR1020020084892
申请日：2002-12-27
Applicant: 한국과학기술연구원
IPC: A61L31/04
Abstract: PURPOSE: Provided is a porous support obtained from biodegradable lactide/epsilon-caprolactone copolymer, which has excellent mechanical properties including flexibility and elasticity suitable to be used in tissue engineering. CONSTITUTION: The porous support obtained from biodegradable lactide/ epsilon-caprolactone copolymer has repeating units represented by formula 1 and a weight average molecular weight of 10,000 or more, wherein the mole ratio of lactide to epsilon-caprolactone is 2:8 to 8:2: wherein each of x and y is an integer of 1 or more, and n is an integer of 18 or more. Particularly, the porous support has a pore size of 1 to 800 micrometers and a porosity of 50-99%.
Abstract translation: 目的：提供由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体，其具有优异的机械性能，包括适合用于组织工程的柔性和弹性。 构成：由生物可降解丙交酯/ε-己内酯共聚物获得的多孔载体具有由式1表示的重复单元，重均分子量为10,000以上，其中丙交酯与ε-己内酯的摩尔比为2：8〜8：2 ：其中x和y各自为1以上的整数，n为18以上的整数。 特别地，多孔载体的孔径为1至800微米，孔隙率为50-99％。
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公开(公告)号：KR100408458B1
公开(公告)日：2003-12-06
申请号：KR1020000082684
申请日：2000-12-27
Applicant: 한국과학기술연구원
IPC: A61L27/56
Abstract: Disclosed is a biocompatible medical material and porous scaffold for use in tissue engineering, made from a biodegradable glycolide/epsilon-caprolactone copolymer having a repeat unit of wherein x and y are integers greater than or equal to 18, the copolymer has an average molecular weight of about 10,000 daltons or more, and the molar ratio of glycolide: epsilon-caprolactone in the copolymer is about 4.0:6.0 to 6.0:4.0.
Abstract translation: 公开了一种用于组织工程的生物相容性医用材料和多孔支架，由具有重复单元的可生物降解的乙交酯/ε-己内酯共聚物制成，其中x和y是大于或等于18的整数，所述共聚物的平均分子量 约10,000道尔顿或更多，共聚物中乙交酯：ε-己内酯的摩尔比为约4.0:6.0至6.0:4.0。
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公开(公告)号：KR1020030032420A
公开(公告)日：2003-04-26
申请号：KR1020010064182
申请日：2001-10-18
Applicant: 한국과학기술연구원
IPC: A61L27/58
Abstract: PURPOSE: A porous substrate of a biodegradable polymer for regenerating an impaired ocular tissue is provided to cure the impaired ocular tissue by installing in the impaired ocular tissue region. CONSTITUTION: The porous substrate of the biodegradable polymer for regenerating the impaired ocular tissue is prepared with the biodegradable polymer selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, polydioxanone, polytrimethylene carbonate and copolymer thereof, and has the pore size of 10 to 800 micrometers, and the porosity of 50 to 99%. The ocular region is selected from the group consisting of cornea, conjunctiva and sclera.
Abstract translation: 目的：提供用于再生受损的眼组织的生物可降解聚合物的多孔底物，以通过安装在受损的眼组织区域中来治愈受损的眼组织。 构成：用于再生受损眼睛组织的可生物降解聚合物的多孔基材由选自聚乙醇酸，聚乳酸，聚己内酯，聚二恶烷酮，聚三亚甲基碳酸酯及其共聚物的生物降解性聚合物制备，孔径为10 至800微米，孔隙率为50至99％。 眼部区域选自角膜，结膜和巩膜。
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公开(公告)号：KR100367041B1
公开(公告)日：2003-01-15
申请号：KR1019990043181
申请日：1999-10-07
Applicant: 한국과학기술연구원
IPC: C08F120/06
Abstract: PURPOSE: A poly-methyl methacrylate having hydrophilic surface and a use thereof as ophthalmic material are provided, which maintains an optical property of PMMA and which reduces adhesion growth of cell and protein. CONSTITUTION: A preparation method of poly-methyl methacrylate having hydrophilic surface is formed by bonding poly-ethylene oxide derivative of formula: NH2-R1-O-(CH2CH2O)n-X containing amino group at the end in the presence of catalyst at the surface of poly-methyl methacrylate chemically. In formula, R1 is (CH2CH2)2-3, n is 15-300, X is hydrogen, CH3, (CH2CH2)2-3-NH2 or (CH2CH2)2-3-NH-(CH2)3-SO3H. The molecular weight of poly-ethylene oxide is 200-10,000. The catalyst is tri-ethylamine.
Abstract translation: 目的：提供一种具有亲水性表面的聚甲基丙烯酸甲酯及其作为眼科材料的用途，其保持了PMMA的光学性能并且减少了细胞和蛋白质的粘附生长。 构成：具有亲水表面的聚甲基丙烯酸甲酯的制备方法是通过在催化剂存在下在表面上结合含有氨基的式：NH2-R1-O-（CH2CH2O）nX的聚环氧乙烷衍生物而形成的 聚甲基丙烯酸甲酯化学。 在通式中，R1是（CH2CH2）2-3，n是15-300，X是氢，CH3，（CH2CH2）2-3-NH2或（CH2CH2）2-3-NH-（CH2）3-SO3H。 聚环氧乙烷的分子量为200-10,000。 催化剂是三乙胺。
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