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31.发明公开
公开(公告)号：KR1020070056601A
公开(公告)日：2007-06-04
申请号：KR1020050115501
申请日：2005-11-30
Applicant: 한국과학기술연구원
IPC: C07D311/30
Abstract: A novel flavone derivative is provided to show excellent antioxidative effect, neuron protecting effect and neuroethological effect, thereby being usefully used for preventing and treating various neurodegenerative diseases such as stroke, chronic degenerative disease, Parkinson's disease and Alzheimer's disease. The flavone derivative is represented by the formula(1), wherein R1 is H or C1-4 alkoxy, R2 is H or hydroxy, each R3 and R4 is independently H or R5, R5 is glucose or -(CH2)mR6(m is from 0 to 3), and R6 is tetrahydrobenzopyran, tetrahydrobenzopyranylalkylacetate or tetrahydrobenzopyranylalkoxyalkyl substituted by at least one substituent selected from the group consisting of C3-7 heterocyclic compound including at least one of N and O; amino which is substituted or unsubstituted by at least one C1-4 alkyl; hydroxy; and hydroxyalkyl. The method for preparing the flavone derivative according to the reaction formula(1) comprises the steps of: (a) synthesizing a compound represented by the formula(VI) from a compound of the formula(I); and (b) after introducing at least one amine or glucose into the compound of the formula(VI) to prepare a compound represented by the formula(VII), deprotecting the compound of the formula(VII) to synthesize the compound of the formula(1). In the reaction formula(1), each R1 to R6 is same as defined above, X is halogen or alkyl halogen, MOM is methoxymethyl, and Bn is benzyl.
Abstract translation: 提供了一种新型的黄酮衍生物，以显示优异的抗氧化作用，神经元保护作用和神经听觉效果，从而有效地用于预防和治疗各种神经变性疾病如中风，慢性退行性疾病，帕金森病和阿尔茨海默病。 黄酮衍生物由式（1）表示，其中R1是H或C1-4烷氧基，R2是H或羟基，R3和R4独立地是H或R5，R5是葡萄糖或 - （CH2）mR6（m是 0至3），R6为四氢苯并吡喃基烷基乙酸酯或四氢苯并吡喃基烷氧基烷基，其被至少一个选自由以下组成的组的C3-7杂环化合物所取代：包括N和O中至少一个的杂环化合物; 被至少一个C 1-4烷基取代或未取代的氨基; 羟基; 和羟烷基。 根据反应式（1）制备黄酮衍生物的方法包括以下步骤：（a）由式（I）化合物合成由式（VI）表示的化合物; 和（b）在将至少一种胺或葡萄糖引入式（VI）化合物中以制备式（Ⅶ）表示的化合物之后，将式（Ⅶ）化合物脱保护，合成式 1）。 在反应式（1）中，每个R 1至R 6与上述定义相同，X为卤素或烷基卤素，MOM为甲氧基甲基，Bn为苄基。
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公开(公告)号：KR1020050001900A
公开(公告)日：2005-01-07
申请号：KR1020030042253
申请日：2003-06-26
Applicant: 한국과학기술연구원
IPC: C07D407/12
Abstract: PURPOSE: A compound having anti-viral activity and an extract of Chrysanthemum morifolium comprising the same are provided, which compound and Chrysanthemum morifolium extract are useful for treatment of diseases caused by HIV(Human immunodeficiency virus) or alleviation of symptom of the diseases. CONSTITUTION: The compound having anti-viral activity represented by formula (1) and pharmaceutically acceptable salts thereof are provided. The extract of Chrysanthemum morifolium having anti-viral activity is obtained by using water and organic solvent, wherein the organic solvent is selected from alcohol, ethyl acetate, dichloromethane and acetone; the extract of Chrysanthemum morifolium comprises compounds of formula (1) to formula (5) as active components wherein R1 is hydrogen, hydroxyl, glucose or rhamnos, R2 is hydrogen or hydroxyl and R is a compound 8.
Abstract translation: 目的：提供具有抗病毒活性的化合物和包含其的菊花提取物，该化合物和菊花提取物可用于治疗由HIV引起的疾病（人类免疫缺陷病毒）或减轻疾病症状。 构成：提供了由式（1）表示的具有抗病毒活性的化合物及其药学上可接受的盐。 通过使用水和有机溶剂获得具有抗病毒活性的菊花提取物，其中有机溶剂选自醇，乙酸乙酯，二氯甲烷和丙酮; 菊花提取物包括式（1）至式（5）的化合物作为活性组分，其中R 1是氢，羟基，葡萄糖或鼠李糖，R2是氢或羟基，R是化合物8。
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33.发明公开
公开(公告)号：KR1020050001899A
公开(公告)日：2005-01-07
申请号：KR1020030042252
申请日：2003-06-26
Applicant: 한국과학기술연구원
IPC: C07C69/757
Abstract: PURPOSE: Provided are a compound having an antioxidant or antivirus activity or its pharmaceutically acceptable salt, Chrysanthemum indicum extract containing the compound, a separation method of the compound from the extract, a pharmaceutical composition containing the compound for treating or preventing HIV or the disease due to the oxidation of cell components, an antioxidant food additive containing the compound and an antioxidant cosmetic containing the compound. CONSTITUTION: The compound is represented by the formula 1, wherein R1 and R2 are H or a caffeoyl group; and R3 is a specific caffeoyl group represented by the formula (a). The Chrysanthemum indicum extract is extracted by using water and an organic solvent. Preferably the organic solvent is at least one selected from the group consisting of an alcohol, ethyl acetate, dichloromethane and acetone. The compound of the formula 1 is separated from the extract by carrying out the column chromatography using a filler selected from the group consisting of silica gel, Sephadex, RP-18, polyamide, Toyopearl and XAD resin.
Abstract translation: 目的：提供含有抗氧化剂或抗病毒活性的化合物或其药学上可接受的盐，含有化合物的菊花提取物，来自提取物的化合物的分离方法，含有用于治疗或预防HIV或疾病的化合物的药物组合物 涉及细胞成分的氧化，含有该化合物的抗氧化食品添加剂和含有该化合物的抗氧化剂化妆品。 构成：该化合物由式1表示，其中R1和R2是H或咖啡酰基; R3是由式（a）表示的特定的咖啡酰基。 菊花提取物通过使用水和有机溶剂萃取。 优选地，有机溶剂是选自醇，乙酸乙酯，二氯甲烷和丙酮中的至少一种。 通过使用选自硅胶，Sephadex，RP-18，聚酰胺，Toyopearl和XAD树脂的填料进行柱色谱，从提取物中分离式1的化合物。
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公开(公告)号：KR1020030088906A
公开(公告)日：2003-11-21
申请号：KR1020020026650
申请日：2002-05-15
Applicant: 한국과학기술연구원
IPC: A61K31/353
Abstract: PURPOSE: Provided is a composition for treating sexual dysfunction which contains a flavonoid compound represented by the formula 1 or 2, and an extract of Sophora flavescens containing them, as active ingredients. The composition inhibits on cGMP-PDE5 and is thus useful for the prevention and treatment of sexual disfunction. CONSTITUTION: A composition for treating sexual dysfunction is characterized by containing, as active ingredients, a flavonoid compound represented by the formula 1 or 2, wherein R1 is a unsubstituted or hydroxy group-substituted linear or branched alkenyl group; R2 is hydrogen, hydroxy or C1-C3 alkoxy; R3 and R4 are individually hydrogen or a hydroxy group; and a dotted line represents single or double bond, and its pharmaceutically acceptable salt, hydrates, solvate, isomer or their mixture.
Abstract translation: 目的：提供一种用于治疗性功能障碍的组合物，其含有由式1或2表示的类黄酮化合物和含有它们的苦参皂甙提取物作为活性成分。 该组合物抑制cGMP-PDE5，因此可用于预防和治疗性功能障碍。 构成：用于治疗性功能障碍的组合物的特征在于，含有作为活性成分的由式1或2表示的类黄酮化合物，其中R1是未取代的或羟基取代的直链或支链烯基; R2是氢，羟基或C1-C3烷氧基; R3和R4分别是氢或羟基; 虚线表示单键或双键，以及其药学上可接受的盐，水合物，溶剂合物，异构体或它们的混合物。
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公开(公告)号：KR100386310B1
公开(公告)日：2003-06-02
申请号：KR1020000041969
申请日：2000-07-21
Applicant: 한국과학기술연구원
IPC: A61K36/855 , A61P31/18 , A61P37/00
Abstract: PURPOSE: An anti-HIV agent containing an alcohol extract of Clerodendron trichotomum and a purified compound separated therefrom an as effective component, in particular an inhibitor for HIV integrase is provided, which has no drug resistance or side effects as defects of a reverse transciptase inhibitor and a protease inhibitor. CONSTITUTION: An alcohol extract of Clerodendron trichotomum having a formula 1 has an anti-HIV activity, in particular an inhibiting activity against HIV integrase. In formula, R1 is H or methyl, R2 is H, caffeoyl, or feruloyl, R3 is H, caffeoyl or feruloyl. For an example, 4.8kg Clerodendron trichotomum is extracted in methanol at room temperature and fractionated into dichloromethane and water. The fraction is subjected to column chromatography with sephadex LH-20 and then silica gel column chromatography to produce 880.8mg compound of the formula 1.
Abstract translation: 目的：提供一种含有Clerodendron trichotomum的醇提取物和从其中分离出作为有效成分的纯化化合物的抗HIV剂，特别是HIV整合酶的抑制剂，其没有作为逆转录酶抑制剂缺陷的抗药性或副作用 和蛋白酶抑制剂。 组成：具有式1的Clerodendron trichotomum的醇提取物具有抗HIV活性，特别是对HIV整合酶的抑制活性。 在通式中，R1是H或甲基，R2是H，咖啡酰或阿魏酰，R3是H，咖啡酰或阿魏酰。 举例来说，在室温下将4.8kg Clerodendron trichotomum在甲醇中萃取并分馏成二氯甲烷和水。 将馏分用交联葡聚糖LH-20进行柱层析，然后进行硅胶柱层析，得到880.8mg式1化合物。
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Patent Agency Ranking
公开(公告)号：KR101746158B1
公开(公告)日：2017-06-13
申请号：KR1020160086407
申请日：2016-07-07
Applicant: 한국과학기술연구원
CPC classification number: A61K36/36 , A23L33/105 , A23V2002/00 , A23V2200/318 , A61K8/97 , A61K2800/81 , A61Q19/00
Abstract: 은시호추출물을유효성분으로서포함하는아토피피부염을개선시키기위한조성물및 그의용도를제공한다.
Abstract translation: 用于改善特应性皮炎的组合物，其包含吉娃娃的提取物作为活性成分，及其用途。
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公开(公告)号：KR101611853B1
公开(公告)日：2016-04-14
申请号：KR1020160005375
申请日：2016-01-15
Applicant: 한국과학기술연구원
IPC: A61K31/7034 , A61K31/7042 , A61K36/28 , A23L1/30 , A61K8/97 , A61Q19/00
Abstract: 본발명은항염증활성이우수한섬쑥부쟁이 () 분획물및 이로부터분리된화합물에관한것이다. 본발명의섬쑥부쟁이의에틸아세테이트분획물과상기분획물로부터분리된활성화합물로서 6'--카페오일로세오사이드 (6'--caffeoylroseoside), 6'--카페오일디히드로시린진 (6'--caffeoyldihydrosyringin), 글레노사이드 (glehnoside)는강력한자유라디칼소거능에의한항산화을가지며, 동시에리포폴리사카라이드 (LPS)에의해유도되는염증성대사산물인 NO (Nitric oxide)과프로스타글란딘 E(PGE), TNF-α (tumour necrosis factor alpha), IL-6 (interleukin-6) 및 IL-1β (interleukin-1beta) 등과같은염증유발성사이토카인 (cytokine)의생성을억제하므로, 염증질환의치료, 예방및 개선이필요한의약품, 화장품, 건강식품등의활성성분으로유용하게사용될수 있다.
Abstract translation: 本发明涉及抗炎活性优异岛紫菀深重（）馏分和由其化合物中分离。 ，6“” - - （caffeoylroseoside徐侧6），以在咖啡馆011“6从乙酸乙酯馏分和骑在本发明的海岛紫菀的级分中分离的活性化合物5天咖啡馆二氢疼痛二进制（6' -caffeoyldihydrosyringin），侧柱里诺（glehnoside）已经hangsanhwaeul由强自由基清除活性，一起脂多糖（NO（一氧化氮）和前列腺素E（PGE的LPS）），其通过炎性代谢物，TNF-α诱导的 它抑制促炎细胞因子（细胞因子），如α（肿瘤坏死因子α），IL-6（白细胞介素-6）和IL-1β（白细胞介素1β的），治疗，预防和炎性疾病的改善的 并且可以有效地用作药物，化妆品，保健食品等的活性成分。
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公开(公告)号：KR1020150135036A
公开(公告)日：2015-12-02
申请号：KR1020140121177
申请日：2014-09-12
Applicant: 한국과학기술연구원
IPC: A61K31/7034 , A61K36/28 , A61P29/00
CPC classification number: A61K31/7034 , A23L29/035 , A61K8/602 , A61K31/7028 , A61K36/28 , A61K2236/00 , Y10S514/824 , Y10S514/825 , Y10S514/857 , Y10S514/886
Abstract: 본발명은항염증활성이우수한섬쑥부쟁이 () 분획물및 이로부터분리된화합물에관한것이다. 본발명의섬쑥부쟁이의에틸아세테이트분획물과상기분획물로부터분리된활성화합물로서 6'--카페오일로세오사이드 (6'--caffeoylroseoside), 6'--카페오일디히드로시린진 (6'--caffeoyldihydrosyringin), 글레노사이드 (glehnoside)는강력한자유라디칼소거능에의한항산화을가지며, 동시에리포폴리사카라이드 (LPS)에의해유도되는염증성대사산물인 NO (Nitric oxide)과프로스타글란딘 E(PGE), TNF-α (tumour necrosis factor alpha), IL-6 (interleukin-6) 및 IL-1β (interleukin-1beta) 등과같은염증유발성사이토카인 (cytokine)의생성을억제하므로, 염증질환의치료, 예방및 개선이필요한의약품, 화장품, 건강식품등의활성성분으로유용하게사용될수 있다.
Abstract translation: 本发明涉及具有优异抗炎活性的Aster glehni级分和从其分离的活性化合物。 本发明提供了Aster glehni的乙酸乙酯级分和从该级分分离的活性化合物，其中6'-O-咖啡酰基玫瑰糖苷，6'-O-咖啡酰二氢肉豆蔻苷和glehnoside由于强的自由基清除能力而具有抗氧化作用，同时 抑制一氧化氮（NO），前列腺素E2（PGE2），肿瘤坏死因子α（TNF-α），白介素-6（IL-6）和白细胞介素-1β（IL-1β）的促炎细胞因子的产生， 是由脂多糖（LPS）引起的炎症代谢物，从而有效地用作治疗，预防和改善炎性疾病所需的药物，化妆品和保健食品的活性成分。
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公开(公告)号：KR1020130125745A
公开(公告)日：2013-11-19
申请号：KR1020130133684
申请日：2013-11-05
Applicant: 한국과학기술연구원
IPC: A61K31/7034 , A61K31/7048 , A61P3/10 , A61P13/12
CPC classification number: Y02A50/478 , Y02A50/479 , A61K31/7048 , A23L33/125 , A61K31/704 , Y10S514/866
Abstract: The present invention provides a composition containing esculin, an esculin derivative, or a pharmaceutically acceptable salt or a solvate thereof as an active ingredient for reducing blood glucose. The present invention provides esculin, an esculin derivative, or a pharmaceutically acceptable salt or solvate thereof as an active ingredient for reducing creatinine in blood.
Abstract translation: 本发明提供含有作为降低血糖的活性成分的曲马素，七叶糖衍生物或其药学上可接受的盐或溶剂合物的组合物。 本发明提供了逃避血浆中的丝氨酸蛋白，七叶树素衍生物或其药学上可接受的盐或溶剂合物作为还原肌酸酐的活性成分。
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公开(公告)号：KR101164020B1
公开(公告)日：2012-07-18
申请号：KR1020060095383
申请日：2006-09-29
Applicant: 한국과학기술연구원
Abstract: 본 발명은 손바닥선인장 추출물을 함유하는 약학 조성물에 관한 것으로, 더욱 상세하게는 손바닥선인장의 부탄올 추출물 또는 이 추출물의 산 가수분해물이 유효성분으로 함유되어 있음으로써 뇌신경 질환, 뇌혈관 질환 또는 심혈관 질환 보다 구체적으로는 뇌졸중, 뇌진탕, 알쯔하이머병, 파킨슨병, 뇌경색, 심근경색 등의 치료 및 예방에 유효한 약학 조성물에 관한 것이다.
손바닥선인장, 부탄올 추출물, 뇌졸중, 허혈, 신경세포 보호, 뇌신경질환
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