公开(公告)号：PT98766B

公开(公告)日：1999-01-29

申请号：PT9876691

申请日：1991-08-23

Applicant: ABBOTT LAB

Inventor： CHU DANIEL T ,  PLATTNER JACOB J ,  HALLAS ROBERT

IPC: C07D455/03 ,  C07D498/06 ,  C07D498/16 ,  C07D513/06 ,  A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/50 ,  A61K31/535 ,  A61K31/54 ,  C07D221/04 ,  C07D221/22 ,  C07D279/36 ,  C07D471/06 ,  C07D513/00

公开(公告)号：GR3021342T3

公开(公告)日：1997-01-31

申请号：GR960402715

申请日：1996-10-16

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K5/04

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：AT141271T

公开(公告)日：1996-08-15

申请号：AT89117428

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10 ,  C07K5/04 ,  C07D221/00

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：DK466889D0

公开(公告)日：1989-09-21

申请号：DK466889

申请日：1989-09-21

Applicant: ABBOTT LAB

Inventor： CHU DANIEL TIM-WO ,  HALLAS ROBERT

IPC: A61K31/00 ,  A61K31/435 ,  A61K31/47 ,  A61K38/00 ,  A61P31/00 ,  A61P31/04 ,  C07D401/04 ,  C07D471/04 ,  C07K1/113 ,  C07K5/06 ,  C07K5/08 ,  C07K5/10

Abstract: 7-(3-A-amino-1-pyrrolidinyl) substituted naphthyridine and quinoline compounds wherein A is a solubilizing group selected from an amino acid residue or polypeptide chain.

公开(公告)号：IT8320510D0

公开(公告)日：1983-04-08

申请号：IT2051083

申请日：1983-04-08

Applicant: ABBOTT LAB

Inventor： TADANIER JOHN SOLOMAN ,  HALLAS ROBERT

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61P31/04 ,  C07H15/224 ,  A61K

公开(公告)号：CA1022168A

公开(公告)日：1977-12-06

申请号：CA198886

申请日：1974-05-03

Applicant: ABBOTT LAB

Inventor： HALLAS ROBERT ,  MARTIN JERRY R ,  TADANIER JOHN S

IPC: A61K31/335 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: 1467296 Erythromycin derivatives ABBOTT LABORATORIES 1 May 1974 [4 May 1973] 19163/74 Heading C2C Novel erythromycin derivatives of the general formula wherein R is a C 1-6 alkyl, C 2-6 alkenyl, or optionally nuclear substituted aryl, benzyl or aroxyalkyl group, R 1 is a hydrogen atom or methyl group, R 2 is a hydrogen atom or C 1-6 alkanoyl group and R 3 is a hydrogen atom or hydroxyl group, provided that R 1 and R 3 are not simultaneously a hydrogen atom and the nuclear substituent is nitro, alkyl or halogen are prepared by reacting the corresponding compound in which the -OSO 2 R group is replaced by -OH with RSO 2 Cl (when R is vinyl in the product, R may be 2-bromoethyl in the starting material), followed optionally by hydrolysis or alcoholysis when R 2 is a C 1-6 alkanoyl group to give the corresponding product wherein R 2 is a hydrogen atom. Pharmaceutical compositions having antibiotic activity comprise, as active ingredient, an erythromycin derivative of the above general formula, together with an appropriate carrier.

公开(公告)号：DE69631609T2

公开(公告)日：2005-01-05

申请号：DE69631609

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： OR SUN ,  PHAN TAM ,  CHU T ,  SPINA P ,  HALLAS ROBERT ,  ELLIOTT L

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：DK0876388T3

公开(公告)日：2004-06-07

申请号：DK96936579

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  PHAN LY TAM ,  CHU DANIEL T ,  SPINA KENNETH P ,  HALLAS ROBERT ,  ELLIOTT RICHARD L

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：BR9714269A

公开(公告)日：2000-04-18

申请号：BR9714269

申请日：1997-04-07

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  PHAN LY TAM ,  CHU DANIEL T ,  SPINA KENNETH P ,  HALLAS ROBERT ,  ELLIOT RICHARD L ,  TUFANO MICHAEL

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  A61K31/71

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of the formula:wherein A, B, D and E, R1, R2, and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：MX9803692A

公开(公告)日：1998-09-30

申请号：MX9803692

申请日：1998-05-08

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  PHAN LY TAM ,  CHU DANIEL T ,  SPINA KENNETH P ,  HALLAS ROBERT ,  ELLIOTT RICHARD L

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Compuestos, o sales farmacéuticamente aceptables y ésteres de los mismos, de las formulas (I); (II); (III) o (IV), en donde A, B, D, y E, R1, R2, y Z se definen específicamente, que tienen actividad antibacteriana; composiciones farmacéuticas que contienen a estos compuestos; tratamiento de infecciones antibacterianos con dichas composiciones, y procesos para la preparacion de los compuestos.