公开(公告)号：EP1007530B1

公开(公告)日：2005-11-16

申请号：EP97924605.5

申请日：1997-05-06

Applicant: ABBOTT LABORATORIES

Inventor： OR, Yat, Sun ,  CLARK, Richard, F. ,  MA, Zhenkun ,  GRIESGRABER, George ,  LI, Leping ,  CHU, Daniel, T.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: Antimicrobial compounds having formula (II), (III), (IV), (V), (VI), (VII), (VIII) and (IX); as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

公开(公告)号：EP1579864A1

公开(公告)日：2005-09-28

申请号：EP05104506.0

申请日：2003-04-23

Applicant: ABBOTT LABORATORIES

Inventor： MA, Zhenkun ,  DJURIC, Stevan ,  FLORJANCIC, Alan S. ,  YONG, Hong ,  GU, Yugui

IPC: A61K31/7048 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates employed in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections in a fish or a mammal using the compounds are disclosed.

公开(公告)号：EP1025114B1

公开(公告)日：2004-02-25

申请号：EP98946087.8

申请日：1998-09-16

Applicant: Abbott Laboratories

Inventor： OR, Yat, Sun ,  MA, Zhenkun ,  CHU, Daniel, T.

IPC: C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Novel 3'-N-modified 6-O-substituted erythromycin ketolide compounds and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I), (II), (III), (IV) or (V), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, as well as a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention.

公开(公告)号：EP1206476A1

公开(公告)日：2002-05-22

申请号：EP00955256.3

申请日：2000-07-26

Applicant: Abbott Laboratories

Inventor： OR, Yat Sun ,  KEYES, Robert F. ,  MA, Zhenkun

IPC: C07H17/08 ,  A61K31/70 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: Compounds of formula (I), formula (II), formula (III), and formula (IV) or pharmaceutically acceptable salts or prodrugs thereof, are antibacterial agents. Compositions containing the compounds, processes for making the compounds, synthetic intermediates employed in the processes, and methods for treatment and prevention of bacterial infections are disclosed.

公开(公告)号：EP1181300A1

公开(公告)日：2002-02-27

申请号：EP00936424.1

申请日：2000-05-31

Applicant: ABBOTT LABORATORIES

Inventor： PHAN, Ly T. ,  OR, Yat Sun ,  MA, Zhenkun ,  CHEN, Yan

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: The invention relates to a novel 6-O-carbamate ketolide compound or a pharmaceutically acceptable salt, ester, solvate or prodrug thereof, to a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of infections in a mammal.

公开(公告)号：EP1233971B1

公开(公告)日：2008-06-04

申请号：EP00982357.6

申请日：2000-12-01

Applicant: ABBOTT LABORATORIES

Inventor： PHAN, Ly, Tam ,  OR, Yat, Sun ,  MA, Zhenkun

IPC: C07H17/00

CPC classification number: C07H17/08

Abstract: The present invention relates to 6-O-alkyl-2-nor-2-substituted ketolide compound or a derivative thereof, a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of in mammals comprising administering said compound.

公开(公告)号：EP1631570A1

公开(公告)日：2006-03-08

申请号：EP03723732.8

申请日：2003-03-12

Applicant: ABBOTT LABORATORIES

Inventor： ANDERSON, David ,  BEUTEL, Bruce ,  BOSSE, Todd, D. ,  CLARK, Richard ,  COOPER, Curt ,  DANDLIKER, Peter ,  DAVID, Caroline ,  GU, Yu-Gui ,  HANSEN, Todd, Matthew ,  HINMAN, Mira ,  KALVIN, Douglas ,  LARSON, Daniel, P. ,  LYNCH, Linda ,  MA, Zhenkun ,  MOTTER, Christopher ,  PALAZZO, Fabio ,  ROSENBERG, Teresa ,  REHM, Tamara ,  SANDERS, William ,  TUFANO, Michael ,  WAGNER, Rolf ,  WEITZBERG, Moshe ,  YONG, Hong ,  ZHANG, Tianyuan

IPC: C07D471/04 ,  A61K31/435 ,  A61P31/04

CPC classification number: C07D471/04

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1259923B1

公开(公告)日：2005-12-14

申请号：EP01920147.4

申请日：2001-02-23

Applicant: ABBOTT LABORATORIES

Inventor： MA, Zhenkun ,  NEMOTO, Peter, A. ,  ZHANG, Souming ,  YONG, Hong ,  OR, Yat, Sun

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC classification number: A61K31/335

Abstract: The invention relates to novel methods for using macrolide anti-infective agents. The macrolide anti-infective agents demonstrate antibacterial activity against multi-drug resistant strains of bacteria and, in particular, methicillin-resistant Staphylococcus aureus (MRSA). Methods for inhibiting the activity of multi-drug resistant bacterial organisms and methods for treating a bacterial infection caused by such organisms are described herein.

公开(公告)号：EP1501846A1

公开(公告)日：2005-02-02

申请号：EP03731049.7

申请日：2003-04-25

Applicant: Abbott Laboratories

Inventor： GU, Yugui ,  MA, Zhenkun ,  YONG, Hong

IPC: C07H17/08 ,  A61K31/7048 ,  A61P31/04

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：EP1501519A1

公开(公告)日：2005-02-02

申请号：EP03719894.2

申请日：2003-04-23

Applicant: Abbott Laboratories

Inventor： SEARLE, Xenia, Beebe ,  DJURIC, Stevan ,  MA, Zhenkun ,  YANG, Fan

IPC: A61K31/7048 ,  C07H17/08

Abstract: Antibacterial compounds having formula (I), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.