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公开(公告)号：HU9602695D0
公开(公告)日：1996-11-28
申请号：HU9602695
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , KLINGE DAGMAR , KROEGER BURKHARD , RASCHACK MANFRED , RHEINHEIMER JOACHIM , RIECHERS HARTMUT , UNGER LILIANE , VOGELBACHER UWE JOSEF , WERNET WOLFGANG
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：ZA952614B
公开(公告)日：1996-09-30
申请号：ZA952614
申请日：1995-03-30
Applicant: BASF AG
Inventor： BAUMANN ERNST , KLINGE DAGMAR , RHEINHEIMER JOACHIM , RIECHERS HARTMUT , VOGELBACHER UWE JOSEF , KROEGER BURKHARD , BIALOJAN SIEGFRIED , WERNET WOLFGANG , BOLLSCHWEILER CLAUS , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , C07D251/26 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：NO964121D0
公开(公告)日：1996-09-27
申请号：NO964121
申请日：1996-09-27
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , A61K31/505 , C07D251/26 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：DE59106997D1
公开(公告)日：1996-01-11
申请号：DE59106997
申请日：1991-07-19
Applicant: BASF AG
Inventor： BACH ALFRED , HILLEN HEINZ , BIALOJAN SIEGFRIED
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公开(公告)号：CA2121601A1
公开(公告)日：1993-06-10
申请号：CA2121601
申请日：1992-11-19
Applicant: BASF AG
Inventor： STRUBE KARL-HERMANN , BIALOJAN SIEGFRIED , KROEGER BURKHARD , FRIEDRICH THOMAS
IPC: A61K38/55 , A61K38/00 , A61P7/02 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/19 , A61K38/58
Abstract: 2121601 9311239 PCTABS00022 Described are new thrombin-inhibiting proteins obtained from terrestrial leeches of the species Haemadipsa and with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-A_ sp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly_ -Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys or an amino-acid sequence obtained by C-terminal shortening the above sequence by one to twelve amino acids. The proteins are suitable for use against illnesses. Also described are the nucleic acids coding for these proteins.
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Patent Agency Ranking
公开(公告)号：MX9206732A
公开(公告)日：1993-05-01
申请号：MX9206732
申请日：1992-11-23
Applicant: BASF AG
Inventor： STRUBE KARL-HERMANN , BIALOJAN SIEGFRIED , KROEGER BURKHARD , FRIEDRICH THOMAS
IPC: A61K38/55 , A61K38/00 , A61P7/02 , C07K14/00 , C07K14/435 , C07K14/81 , C07K14/815 , C12N15/09 , C12N15/15 , C12P21/02 , C12R1/19 , C07K15/08
Abstract: PCT No. PCT/EP92/02661 Sec. 371 Date May 18, 1994 Sec. 102(e) Date May 18, 1994 PCT Filed Nov. 19, 1992 PCT Pub. No. WO93/11239 PCT Pub. Date Oct. 6, 1993.Novel thrombin-inhibitory proteins from terrestrial leeches of the genus Haemadipsa with the amino-acid sequence Ile-Arg-Phe-Gly-Met-Gly-Lys-Val-Pro-Cys-Pro-Asp-Gly-Glu-Val-Gly-Tyr-Thr-Cys-Asp-Cys-Gly-Glu-Lys-Ile-Cys-Leu-Tyr-Gly-Gln-Ser-Cys-Asn-Asp-Gly-Gln-Cys-Ser-Gly-Asp-Pro-Lys-Pro-Ser-Ser-Glu-Phe-Glu-Glu-Phe-Glu-Ile-Asp-Glu-Glu-Glu-Lys, or an amino-acid sequence which is obtained by C-terminal truncation of this sequence by from one to twelve amino acids, are described. The proteins are suitable for controlling diseases. Also described are the nucleic acids coding for these proteins.
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公开(公告)号：ES2178676T3
公开(公告)日：2003-01-01
申请号：ES95926898
申请日：1995-07-14
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JURGEN
IPC: C07D239/26 , A61K31/505 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/26 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D401/00 , C07D401/12
Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：NO312030B1
公开(公告)日：2002-03-04
申请号：NO970162
申请日：1997-01-14
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN , DRESCHER KARLA
IPC: C07D239/26 , A61K31/505 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/26 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D401/00 , C07D401/12 , C07D239/28 , C07D403/12 , C07D403/14
Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.
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公开(公告)号：AT204471T
公开(公告)日：2001-09-15
申请号：AT95914301
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROEGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：BG63257B1
公开(公告)日：2001-07-31
申请号：BG10111097
申请日：1997-01-06
Applicant: BASF AG
Inventor： HELLENDAHL BEATE , LANSKY ANNEGRET , MUNSCHAUER RAINER , BIALOJAN SIEGFRIED , UNGER LILIANE , TESCHENDORF HANS-JUERGEN , WICKE KARSTEN , DRESCHER KARLA
IPC: C07D239/26 , A61K31/505 , A61K31/506 , A61P25/16 , A61P25/24 , A61P25/26 , C07D239/38 , C07D239/46 , C07D239/56 , C07D239/60 , C07D401/00 , C07D401/12
Abstract: The invention relates to pyrimidine compounds with the formula wherein the meanings of the substituents are shown in the description. The compounds have affinity to the dopamine D3-receptors and can be applied for the treatment of diseases which react to dopamine D3-receptor antagonists, or agonists, respectively. 20 claims
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