公开(公告)号：FI802960A

公开(公告)日：1981-04-14

申请号：FI802960

申请日：1980-09-19

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  FRANKE ALBRECHT ,  PHILIPSBORN GERDA VON ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：FI76550C

公开(公告)日：1988-11-10

申请号：FI821252

申请日：1982-04-07

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78

公开(公告)号：FI76550B

公开(公告)日：1988-07-29

申请号：FI821252

申请日：1982-04-07

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS JOERG ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/78

公开(公告)号：NO157452C

公开(公告)日：1988-03-23

申请号：NO821018

申请日：1982-03-26

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER CLAUS D ,  RASCHACK MANFRED ,  PHILIPSBORN GERDA VON

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：CA1233465A

公开(公告)日：1988-03-01

申请号：CA469137

申请日：1984-12-03

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D207/335

Abstract: Aminopropanol derivatives of the formula I where R1 and R2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R1 and R2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and- is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4 yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, processes for their preparation, and antiarrhythmic agents containing these compounds.

公开(公告)号：NO157452B

公开(公告)日：1987-12-14

申请号：NO821018

申请日：1982-03-26

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  MUELLER CLAUS D ,  RASCHACK MANFRED ,  PHILIPSBORN GERDA VON

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: Bispidine derivatives of the formula I I where R is hydrogen or amino, and their salts with physiologically tolerated acids. The compounds have antiarrhythmic properties.

公开(公告)号：CA1207797A

公开(公告)日：1986-07-15

申请号：CA414272

申请日：1982-10-27

Applicant: BASF AG

Inventor： DENGEL FERDINAND ,  TREIBER HANS J ,  SEITZ WERNER ,  MUELLER CLAUS D

IPC: A61K31/135 ,  A61P9/06 ,  C07C67/00 ,  C07C209/00 ,  C07C209/48 ,  C07C211/27 ,  C07C211/29 ,  C07C213/00 ,  C07C217/54 ,  C07C217/62 ,  C07C87/28 ,  C07C93/14

Abstract: Substituted 1,5-diaminopen-tanes of the formula I where R1 and R2 are each hydrogen or C1-C6-alkyl, R3 is C1-C12-alkyl, R4, R5, R6, R7, R8 and R9 are each hydrogen, halogen, C1-C4-alkyl, C1-C4-alkoxy or trifluoromethyl and R10 is hydrogen or methyl, and their salts with physiologically tolerated acids, their preparation and drugs containing these compounds. The substances can be used for the treatment of cardiac arrhythmias.

公开(公告)号：CS238634B2

公开(公告)日：1985-12-16

申请号：CS783782

申请日：1982-04-06

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS D ,  FRIEDRICH LUDWIG ,  ZIMMERMANN FRANK ,  SEITZ WERNER ,  TREIBER HANS J ,  DENGEL FERDINAND ,  FRANK WOLFRAM ,  KURBJUWEIT HANS-GEORG ,  MUELLER CLAUS D

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  C07C121/66

公开(公告)号：CA1155851A

公开(公告)日：1983-10-25

申请号：CA365857

申请日：1980-12-01

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  VON PHILIPSBORN GERDA ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/4433 ,  A61K31/445 ,  A61P9/06 ,  C07D333/38 ,  C07D409/12 ,  C07D211/06

Abstract: O.Z. 0050/034,178 Substituted piperidinoalkyl ethers of 3-hydroxy-thiophene-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and which may be used in the treatment of cardiac arrhythmias.

公开(公告)号：CA1155124A

公开(公告)日：1983-10-11

申请号：CA361718

申请日：1980-10-07

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  FRANKE ALBRECHT ,  VON PHILIPSBORN GERDA ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D401/00

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.