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公开(公告)号:AT276732T
公开(公告)日:2004-10-15
申请号:AT00110475
申请日:2000-05-17
Applicant: BASF AG
Inventor: PRECHTL FRANK DR , HABECK THORSTEN DR , WESTENFELDER HORST , WUENSCH THOMAS DR
IPC: C07D311/58 , A61K8/00 , A61K8/30 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/40 , A61K8/49 , A61K47/08 , A61K47/14 , A61K47/16 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C255/34 , C07C261/02 , C07D311/04 , C07D495/04 , C08K5/07 , C08K5/1545 , C08K5/20 , C08K5/315 , C08K5/3435 , C08K5/42 , C08L101/00 , C09K3/00 , C09K15/06 , C09K15/16 , C09K15/20 , C09K15/30 , A61K7/42 , C08K5/16
Abstract: 6-Vinyl-3,4-dihydro-2H-1-benzopyran, 6-vinyl-1,2,3,4-tetrahydronaphthalene or 6-vinyl-1,2,3,4-tetrahydroquinoline derivatives (I) are used as photostable ultraviolet (UV) filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation. Compounds of formula (I) are used as photostable UV filters in cosmetic and pharmaceutical compositions for protecting human skin and hair against solar radiation: X = O, CO, optionally substituted imino or CR9R10; Y = CO or CR9R10; R1, R2 = CN, alkanoyl, aroyl, alkoxycarbonyl, aryloxycarbonyl, optionally substituted carbamoyl, alkylsulfinyl, arylsulfinyl, alkylsulfonyl, arylsulfonyl or optionally substituted sulfamoyl; R3 = H, CN, OH, COOH, CONH2, Q, OQ, CONHQ or COOQ; Q = 1-20C alkyl or 5-20C aryl; R4 = H, OH, NH2, Q or OQ; R5-R10 = H or 1-20C alkyl, or R7+R8 can be oxo. Independent claims are also included for the following: (1) use of (I) as photoprotective agents for stabilizing plastics; (2) cosmetic compositions for protecting human epidermis and hair against UV light of wavelength 280-400 nm, comprising (I) in a carrier; and (3) new compounds of formula (II): R3' = lower alkyl; R4' = H, lower alkyl or lower alkoxy; X' = O or CRR; R = H or lower alkyl.
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公开(公告)号:ES2201621T3
公开(公告)日:2004-03-16
申请号:ES99122884
申请日:1999-11-18
Applicant: BASF AG
Inventor: HABECK THORSTEN DR , PRECHTL FRANK DR , WUNSCH THOMAS DR , WESTENFELDER HORST
IPC: A61K8/00 , A61K8/30 , A61K8/40 , A61K8/49 , A61K31/275 , A61K31/277 , A61Q1/00 , A61Q1/04 , A61Q17/04 , A61Q19/00 , C07C255/37 , A61K7/42
Abstract: alpha -Alkyl-styryl derivatives (I) are used as photostable UV-filter in cosmetic or pharmaceutical compositions for protecting the human skin or hair against the sun light, optionally combined with other components absorbing in the UV range. alpha -Alkyl-styryl derivatives of formula (I) are used as photostable UV-filter in cosmetic or pharmaceutical compositions for protecting the human skin or hair against the sun light, optionally combined with other components absorbing in the UV range. R , R = H, OH, NH2, 1-12C alkyl, 1-12C alkoxy, 1-12C alkylamino, 1-12C dialkylamino, water soluble substituents such as carboxylate, sulfonate or ammonium residues; R , R = COOR , COR , CONR R or CN; R = 1-12C alkyl; R , R = H, 1-12C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (all optionally substituted); A = O, S or NR B' = 1-12C alkylene, 4-12C cycloalkylene, 8-22C aralkylene, 9-21C monooxoaralkylene or -(X)n-Y'-; R = H or 1-12C alkyl; X = -(CH2)2-Z-, -(CH2)3-Z-, -CH(CH3)2-CH2-Z-, -(CH2)4-Z- or -CH2-CH(CH2-CH3)-Z-; Y' = -(CH2)2-, -(CH2)3-, -CH(CH3)-CH2-, -(CH2)4- or -CH2-CH(CH2-CH3)-; Z = O or S; n = 1-150; two of R , R and R = form 5- to 6-membered ring fused to the benzene ring. An Independent claim is also included for a sunscreen comprising the cosmetic and pharmaceutical composition for protecting the human epidermis and hair against UV light (280-400 nm) containing (I).
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公开(公告)号:PT1008586E
公开(公告)日:2003-12-31
申请号:PT99122878
申请日:1999-11-18
Applicant: BASF AG
Inventor: WESTENFELDER HORST , WUNSCH THOMAS , THORSTEN HABECK DR
IPC: A61K8/00 , A61K8/40 , A61Q17/00 , A61Q17/04 , C07C67/343 , C07C69/618 , C07C253/30 , C07C255/41 , C09K3/00 , A61K7/42
Abstract: New oligomeric 4,4-diarylbutadiene carboxylic acid ester or amide sunscreen compounds. Oligomeric 4,4-diarylbutadiene carboxylic acid esters or amides of formula (I) are new. R1, R2 = H; aliphatic-, cycloaliphatic-, aromatic- or araliphatic- group; or carboxylate, sulfonate or ammonium; R3 = aliphatic, cycloaliphatic, aromatic, araliphatic or heterocyclic group; carbonyl, sulfonyl, phosphonyl, carboxylic acid ester or CN; Y = O or N(R4); R4 = H or aliphatic-, cycloaliphatic-, aromatic-,araliphatic or heterocyclic group; m = 2-10; n = 1-3 X = the residue of a polyol with 2-10 OH groups (corresponding to m). Am Independent claim is included for preparation of (I).
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34.
公开(公告)号:AU757965B2
公开(公告)日:2003-03-13
申请号:AU3680199
申请日:1999-06-25
Applicant: BASF AG
Inventor: HABECK THORSTEN , WESTENFELDER HORST , WUNSCH THOMAS
IPC: A61K47/06 , A61K8/00 , A61K8/30 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K31/00 , A61K31/075 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61P17/00 , A61P17/16 , A61Q1/00 , A61Q1/04 , A61Q5/00 , A61Q17/04 , C07C59/40 , C07C69/612 , C07C69/618 , C07C69/73 , C07C69/734 , C07C69/738 , C07C233/40 , C07C309/12 , C07C309/58 , C07C309/59 , C09K3/00 , A61K7/06 , A61K7/42 , C07C233/22
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公开(公告)号:ES2179389T3
公开(公告)日:2003-01-16
申请号:ES98100435
申请日:1998-01-13
Applicant: BASF AG
Inventor: DROGEMULLER MICHAEL DR , BOMM VOLKER DR , SCHEHLMANN VOLKER DR , WESTENFELDER HORST
IPC: C07D215/42 , A61K8/00 , A61Q17/04 , C07C225/14 , C07C229/54 , C07C237/30 , C07C309/46 , C07C311/39 , C09K3/00 , A61K7/42
Abstract: Arylaminomethylene-camphor derivatives of formula (I) are new: R1 = H or Me; R2 = H, 1-6C alkyl, 3-8C cycloalkyl, 2-6C alkenyl; 3-8C cycloalkenyl or aryl (optionally substituted); R3 = H, 1-6C alkyl, 3-8C cycloalkyl, aryl (optionally substituted), 1-6C alkoxy or 1-8C acyl; and Ar = aryl or heteroaryl (both optionally substituted); NB the double bond is Z or E configuration.
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公开(公告)号:DK0888276T3
公开(公告)日:2002-03-25
申请号:DK97908182
申请日:1997-03-06
Applicant: BASF AG
Inventor: KANDZIA CHRISTOF , WESTENFELDER HORST , SCHEHLMANN VOLKER
IPC: A61K8/00 , A61K8/35 , A61K31/00 , A61K31/125 , A61P17/00 , A61P17/16 , A61Q17/04 , C07C45/51 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C225/22 , C09K15/06 , A61K7/42
Abstract: PCT No. PCT/EP97/01122 Sec. 371 Date Sep. 3, 1998 Sec. 102(e) Date Sep. 3, 1998 PCT Filed Mar. 6, 1997 PCT Pub. No. WO97/33855 PCT Pub. Date Sep. 18, 1997The invention relates to cinnamylidenecamphor derivatives of the formula (1) where the diene system is in the Z,Z, Z,E, E,Z or E,E configuration and R1 is H, CH3, R2 is C1-C6-alkyl, C1-C6-alkoxy, halogen, NR3H, NR32, R3 is C1-C4-alkyl, R4 is H, C1-C6-alkyl, n is 1, 2, and to its use.
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公开(公告)号:DE19928033A1
公开(公告)日:2000-12-21
申请号:DE19928033
申请日:1999-06-18
Applicant: BASF AG
Inventor: HABECK THORSTEN , PRECHTL FRANK , WUENSCH THOMAS , WESTENFELDER HORST
IPC: C07D233/64 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/49 , A61K47/22 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07D239/70 , C07D263/56 , C07D277/64 , A61K7/40
Abstract: Use of new and known bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. Also new is their use for the protection of plastics. Use of bicyclic and tricyclic enamines as UV filters in cosmetic and pharmaceutical preparations is new. R and R = CN; alkylcarbonyl; alkoxycarbonyl; aryloxycarbonyl; or optionally substituted aminocarbonyl; R = H; 1-20C alkyl; 3-20C cycloalkyl; or -CH2-CH2-SO3 M ; M = cation; X = -O-; -S-; or -N(R )-; Z' = group of formula (ii) or (iii): R = H; alkyl, cycloalkyl, alkoxy, cycloalkoxy, alkoxycarbonyl, alkyl-NH-CO-, (alkyl)2-NH-CO-, alkyl-NH- or (alkyl)2N- (each with up to 20C); CN; NH2; or SO3 M and more than 1 R can be present. Independent claims are also included for: (1) the use of compounds (I) as light screening agents for the protection of plastics; (2) (I; Z' = (iii); and (3) (I; Z' = (ii); R4 = R40; R1, R2 = R10, R20 respectively) R and R = CN or 2-10C alkoxycarbonyl optionally substituted with -(CH2)n-SO3 M ; R = H; CH3; or -(CH2)n-SO3 M ; R = H; 1-8C alkyl; 1-8C alkoxy; or -SO3 M ; n = 2 or 3; M = H or HN(R )(R )(R ) ; R -R = H lower alkyl optionally substituted with OH; or a metal cation; but at least one -(CH2)n-SO3 M or -SO3 M must be present.
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公开(公告)号:AU3315699A
公开(公告)日:1999-12-16
申请号:AU3315699
申请日:1999-06-03
Applicant: BASF AG
Inventor: SCHUHMACHER PETER , SCHNEIDER NORBERT , WESTENFELDER HORST , HAREMZA SYLKE , HABECK THORSTEN , MEYER FRANK
IPC: A61K8/00 , A61K8/02 , A61K8/23 , A61K8/25 , A61K8/29 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/41 , A61K8/46 , A61K8/49 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/97 , A61K8/98 , A61K31/255 , A61K31/34 , A61P17/16 , A61Q1/00 , A61Q1/04 , A61Q1/10 , A61Q5/00 , A61Q17/04 , A61Q19/00 , C09B67/20 , C09C3/08 , C09K3/00 , A61K7/027 , A61K7/021 , A61K7/42
Abstract: Liquid crystal compositions forming a cholesteric phase with a pitch of less than 450 nm, comprising either at least one polymerizable chiral liquid crystal monomer or a mixture of at least one polymerizable achiral liquid crystal monomer and at least one chiral additive, are used as ultraviolet filters for protecting skin or hair against solar radiation. Liquid crystal compositions forming a cholesteric phase with a pitch of less than 450 nm, comprising either: (a) at least one polymerizable chiral liquid crystal monomer of formula (I); or (b) a mixture of at least one polymerizable achiral liquid crystal monomer of formula (II) and at least one chiral additive, are used as ultraviolet (UV) filters in cosmetic and pharmaceutical compositions for protecting human skin or hair against solar radiation: A -A = spacers with a chain length of 1-30C; Y -Y = bonds, O, S, C(O)O, OC(O), CH=CHC(O)O, OC(O)O, C(O)N(R), N(R)C(O), CH2O, OCH2, CH=N, N=CH or N=N; M , M = mesogenic groups; R = H or 1-4C alkyl; Z = H, 1-4C alkyl or a polymerizable group, at least one being a polymerizable group; Z , Z = H, 1-4C alkyl or polymerizable groups, at least one being a polymerizable group; X = an n-valent chiral group; m, o, p = 0 or 1; n = 1-6. Independent claims are also included: (1) use of the liquid crystal compositions as photostable UV reflectors; (2) use of the liquid crystal compositions as UV stabilizers in cosmetic and pharmaceutical formulations; (3) pigments containing the polymerized liquid crystal compositions.
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公开(公告)号:AU711515B2
公开(公告)日:1999-10-14
申请号:AU6820296
申请日:1996-08-08
Applicant: BASF AG
Inventor: JACHOW HARALD , SCHWAB EKKEHARD , KORMANN CLAUDIUS , DAUSCH WILMA , SPERLING KARIN , WESTENFELDER HORST
IPC: A61K8/19 , A61K8/00 , A61K8/04 , A61K8/26 , A61K8/29 , A61Q17/04 , A61Q19/00 , C01G23/053 , C09C1/36 , A61K7/00
Abstract: PCT No. PCT/EP96/03504 Sec. 371 Date Feb. 12, 1998 Sec. 102(e) Date Feb. 12, 1998 PCT Filed Aug. 8, 1996 PCT Pub. No. WO97/07058 PCT Pub. Date Feb. 27, 1997Titanium dioxide pigments are obtainable by complete hydrolysis of a hydrolyzable titanium compound at from 0 to 100 DEG C. with intensive stirring and with setting of a pH in the range from 3 to 8 and maintenance of this pH within a range of 0.3 units. The titanium dioxide pigments can be employed for the production of cosmetic preparations and medicaments.
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公开(公告)号:AU9718198A
公开(公告)日:1999-07-08
申请号:AU9718198
申请日:1998-12-17
Applicant: BASF AG
Inventor: HABECK THORSTEN , HAREMZA SYLKE , TRAUTH HUBERT , SCHEHLMANN VOLKER , WESTENFELDER HORST
IPC: A61K8/49 , A61K8/00 , A61K31/4035 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07D209/46 , C08K5/3417 , C08L101/00 , C09D7/12 , C09K3/00 , C09K15/30 , C08K5/3447 , A61K47/22
Abstract: Use of isoindolinone derivatives of formula (I) as stabilizers for organic materials is new, where: R = H, COOR , COR , CONR R , CN, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted); R = COOR , COR , CONR R or CN; or R +R = 7-10C bicycloalkyl or 7-10C bicycloalkenyl; R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, 1-12C alkoxy, 1-20C alkoxycarbonyl, 1-12C alkylamino, 1-12C dialkylamino, aryl, heteroaryl (optionally substituted) or a water-solubilizing carboxylate, sulfonate or alkylammonium group; R and R = H, 1-20C alkyl, 2-10C alkenyl, 3-10C cycloalkyl, 3-10C cycloalkenyl, aryl or heteroaryl (optionally substituted). An Independent claim is included for compounds (I) as medicaments.
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