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公开(公告)号：BR0112675A
公开(公告)日：2003-06-24
申请号：BR0112675
申请日：2001-07-18
Applicant: BAXTER INT
Inventor： BREILLATT JULIAN P JR , STERNBERG SHMUEL
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32.发明专利
公开(公告)号：CA2461349A1
公开(公告)日：2003-04-03
申请号：CA2461349
申请日：2002-09-25
Applicant: BAXTER INT
Inventor： KIPP JAMES E , DUNHAM ANDREW J , DOTY MARK J , NARAYANAN KRISHNASWAMY , STERNBERG SHMUEL , JAYSWAL NAILESH , BRYNJELSEN SEAN
IPC: A61K9/14 , A61K9/19 , A61K9/51 , A61K31/496 , A61K45/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , B01J13/04
Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueou s phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo deliver y, particularly by parenteral routes.
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公开(公告)号：DE69417549D1
公开(公告)日：1999-05-06
申请号：DE69417549
申请日：1994-12-20
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL , LYNN DANIEL
IPC: A61M1/34 , A61K35/14 , A61K35/18 , A61M1/02 , A61M1/36 , B01D29/01 , B01D35/02 , B01D39/08 , B01D39/16 , B01D39/18 , B01D39/20 , B01D25/00 , B01D29/50 , B01D35/00 , B01D35/30
Abstract: A method correlates average fiber diameter with performance for a complex filtration media comprising a matrix of fibers having a fibrillated component with a diameter so small (e.g., less than 0.01 microns), that cannot be physically measured with accuracy. The method manufactures a selected matrix, derives the number average diameter of the fibers according to prescribed steps, some of which do not require actual physical measurements, and observes a performance characteristic. The method repeats the foregoing steps for different matrixes, yielding different number average diameters. The method expresses change in the selected performance characteristic as a function of change in number average diameter of the matrices.
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公开(公告)号：CA2237019A1
公开(公告)日：1998-04-02
申请号：CA2237019
申请日：1997-09-22
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL , PEKKARINEN MICHAEL O , PRINCE PAUL R , BELLAMY DAVID JR
IPC: A61M1/26 , A61M1/34 , B01D39/16 , B01D61/14 , B01D61/22 , B01D63/16 , B01D65/08 , B01D69/00 , B01D69/02 , A61K35/14
Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.
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公开(公告)号：ZA9410259B
公开(公告)日：1995-08-29
申请号：ZA9410259
申请日：1994-12-22
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL
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Patent Agency Ranking
公开(公告)号：CA2155732A1
公开(公告)日：1995-06-29
申请号：CA2155732
申请日：1994-12-20
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL , LYNN DANIEL R
IPC: A61M1/34 , A61K35/14 , A61K35/18 , A61M1/02 , A61M1/36 , B01D29/01 , B01D35/02 , B01D39/08 , B01D39/16 , B01D39/18 , B01D39/20 , B01D69/12 , B01D61/18
Abstract: The filter device (16) for removing leukocytes is disclosed. The outer housing (18) enclosing the filter pad assembly (20) includes two sheets (44, 46) of flexible plastic material. The filter device (16) includes tangential side ports (36, 38) as an inlet and an outlet. The filter pad assembly (20) includes a composite of three media regions (28, 30, 32) including noncontiguous layers (40) having an overall thickness of greater than about 6 mm but not more than about 10 mm. Each non-contiguous layer (40) comprises an interlocked matrix of polyester fibers, fiberglass fibers, and cellulose acetate fibrets. The matrix has a number average fiber diameter no greater than about 0.23 micron.
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37.发明专利
公开(公告)号：ES2340250T3
公开(公告)日：2010-06-01
申请号：ES01905092
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: Dispositivo (110) para inactivar agentes patógenos en fluidos, que comprende: un recipiente (112) permeable a la radiación que comunica con un fluido de una corriente de fluido; una mezcladora (126, 128) dispuesta dentro del recipiente y que forma un intersticio entre la mezcladora (126, 128) y el recipiente (112), una fuente de radiación dispuesta a una distancia fija del recipiente, irradiando la fuente de radiación el fluido que se desplaza a través del recipiente, caracterizado porque la mezcladora comprende una superficie en cascada (128) y, a causa de su geometría, produce una turbulencia dentro del flujo de fluido que se desplaza a través del intersticio; y la fuente de radiación se selecciona entre el grupo consistente en radiación ultravioleta, gamma y por haz electrónico.
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公开(公告)号：DE60141509D1
公开(公告)日：2010-04-22
申请号：DE60141509
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： WOO LECON , BOGGS DANIEL R , STERNBERG SHMUEL , SANDFORD CRAIG , KHARE ATUL , BREILLATT JULIAN
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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39.发明专利
公开(公告)号：CA2398247C
公开(公告)日：2008-12-02
申请号：CA2398247
申请日：2001-01-26
Applicant: BAXTER INT
Inventor： STERNBERG SHMUEL , SANDFORD CRAIG , BOGGS DANIEL R , WOO LECON , BREILLATT JULIAN , KHARE ATUL
Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to th e radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows throughthe belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).
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40.发明专利
公开(公告)号：AU2002337692B2
公开(公告)日：2007-09-13
申请号：AU2002337692
申请日：2002-09-25
Applicant: BAXTER INT
Inventor： DUNHAM ANDREW J , BRYNJELSEN SEAN , JAYSWAL NAILESH , DOTY MARK J , NARAYANAN KRISHNASWAMY , STERNBERG SHMUEL , KIPP JAMES E
IPC: A61K9/14 , A61K9/19 , A61K9/51 , A61K31/496 , A61K45/00 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/24 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/42 , B01J13/04
Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.
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