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公开(公告)号：FI883248A
公开(公告)日：1989-01-11
申请号：FI883248
申请日：1988-07-07
Applicant: HOECHST AG
Inventor： WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD , GRANZER ERNOLD
IPC: C12N9/99 , A61K31/19 , A61K31/22 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/381 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C31/125 , C07C31/13 , C07C31/135 , C07C31/137 , C07C33/025 , C07C33/12 , C07C33/14 , C07C33/28 , C07C33/38 , C07C33/46 , C07C33/48 , C07C41/00 , C07C43/13 , C07C43/178 , C07C47/00 , C07C47/21 , C07C51/00 , C07C51/09 , C07C59/42 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/58 , C07C59/64 , C07C67/00 , C07C69/65 , C07C69/66 , C07C69/675 , C07C69/732 , C07C69/738 , C07C253/00 , C07D307/34 , C07D307/54 , C07D309/30 , C07D333/02 , C07D333/38 , C07D405/06 , C07D407/02 , C07D407/06 , C07D409/02 , C07D409/06 , C07C
Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).
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公开(公告)号：DK383988A
公开(公告)日：1989-01-11
申请号：DK383988
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD , GRANZER ERNOLD
IPC: C12N9/99 , A61K31/19 , A61K31/22 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/381 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C31/125 , C07C31/13 , C07C31/135 , C07C31/137 , C07C33/025 , C07C33/12 , C07C33/14 , C07C33/28 , C07C33/38 , C07C33/46 , C07C33/48 , C07C41/00 , C07C43/13 , C07C43/178 , C07C47/00 , C07C47/21 , C07C51/00 , C07C51/09 , C07C59/42 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/58 , C07C59/64 , C07C67/00 , C07C69/65 , C07C69/66 , C07C69/675 , C07C69/732 , C07C69/738 , C07C253/00 , C07D307/34 , C07D307/54 , C07D309/30 , C07D333/02 , C07D333/38 , C07D405/06 , C07D407/02 , C07D407/06 , C07D409/02 , C07D409/06 , C07C69/734 , C07C47/105 , C07C47/17 , C07C47/198 , C07C47/232 , C07C47/24 , C07C47/277 , C07C69/708 , C07C69/736 , C07C121/66 , C07C121/70 , C07C121/75
Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).
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公开(公告)号：NO883285D0
公开(公告)日：1988-07-22
申请号：NO883285
申请日：1988-07-22
Applicant: HOECHST AG
Inventor： WESS GUNTHER , BARTMANN WILHELM , BECK GERHARD , ANAGNOSTOPOULOS HIRISTO
IPC: A61K31/085 , A61K31/38 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/34 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/00 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D317/38 , C07D333/16 , C07C149/00
Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
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公开(公告)号：FI883454A0
公开(公告)日：1988-07-21
申请号：FI883454
申请日：1988-07-21
Applicant: HOECHST AG
Inventor： WESS GUENTHER , BARTMANN WILHELM , BECK GERHARD , ANAGNOSTOPULOS HIRISTO
IPC: A61K31/085 , A61K31/38 , A61K31/10 , A61K31/12 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/34 , A61K31/381 , A61K31/395 , A61K31/41 , A61K31/44 , A61K31/535 , A61K31/5375 , A61P1/04 , A61P11/00 , A61P17/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07C41/00 , C07C43/00 , C07C43/178 , C07C43/20 , C07C43/235 , C07C43/263 , C07C45/00 , C07C47/52 , C07C49/84 , C07C51/00 , C07C59/125 , C07C65/21 , C07C67/00 , C07C69/007 , C07C69/025 , C07C69/675 , C07C69/92 , C07C201/00 , C07C235/06 , C07C235/16 , C07C239/00 , C07C239/14 , C07C313/00 , C07C317/00 , C07C317/04 , C07C317/18 , C07C317/22 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/00 , C07C323/16 , C07C323/19 , C07C323/22 , C07C323/52 , C07C323/56 , C07C323/60 , C07C323/65 , C07D213/30 , C07D257/04 , C07D295/18 , C07D317/36 , C07D317/38 , C07D333/16 , C07C
Abstract: Leukotriene antagonists, a process for the preparation thereof, and the use thereof for the treatment of diseases (I) in which R1, R2, R3, R4, R5 and X have the indicated meanings, a process for the preparation of these compounds, the use thereof as pharmaceuticals, and pharmaceutical products based on these compounds, are described.
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公开(公告)号：NO883074D0
公开(公告)日：1988-07-08
申请号：NO883074
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： BERGMANN ANDREAS , BARTMANN WILHELM , BECK GERHARD , LAU HANS-HERMANN
IPC: C07D213/30 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61P3/06 , A61P9/10 , C07C45/68 , C07C47/55 , C07C51/00 , C07C51/09 , C07C59/00 , C07C59/125 , C07C59/48 , C07C59/68 , C07C59/72 , C07C59/90 , C07C67/00 , C07C313/00 , C07C323/52 , C07C333/04 , C07D213/55 , C07D239/26 , C07D309/10 , C07D309/30 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D493/04 , C07D493/14 , C07F7/18 , C07H15/18 , C07D309/00
Abstract: 3-Desmethyl-4-fluoromevalonic acid derivatives of the formula I and the corresponding dihydroxycarboxylic acid derivatives of the formula II … … in which R, X and Y have the meanings given, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I or formula II are additionally described.
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Patent Agency Ranking
公开(公告)号：NO883071D0
公开(公告)日：1988-07-08
申请号：NO883071
申请日：1988-07-08
Applicant: HOECHST AG
Inventor： WESS GUNTHER , BARTMANN WILHELM , BECK GERHARD , GRANZER ERNOLD
IPC: C12N9/99 , A61K31/19 , A61K31/22 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/381 , A61P3/06 , A61P9/10 , A61P43/00 , C07C27/00 , C07C31/125 , C07C31/13 , C07C31/135 , C07C31/137 , C07C33/025 , C07C33/12 , C07C33/14 , C07C33/28 , C07C33/38 , C07C33/46 , C07C33/48 , C07C41/00 , C07C43/13 , C07C43/178 , C07C47/00 , C07C47/21 , C07C51/00 , C07C51/09 , C07C59/42 , C07C59/48 , C07C59/54 , C07C59/56 , C07C59/58 , C07C59/64 , C07C67/00 , C07C69/65 , C07C69/66 , C07C69/675 , C07C69/732 , C07C69/738 , C07C253/00 , C07D307/34 , C07D307/54 , C07D309/30 , C07D333/02 , C07D333/38 , C07D405/06 , C07D407/02 , C07D407/06 , C07D409/02 , C07D409/06 , C07C69/00 , C07D309/00
Abstract: 3,5-dihydroxycarboxylic acids of formula (I) and their lactones of formula (II) are new: A-B = CH-CH or C=C; X-Y = CH2CH2 or CH=CH; R1 and R2 are each up to 20C, opt. unsatd., alkyl (opt. substd. by 1-6C alkoxy or OCOR5); 3-7C cycloalkyl; phenyl, thiophene, furan or naphthalene residue (these all opt. substd. by 1-3 of halo, 1-6C alkyl or alkoxy, 3-7C cycloalkyl or OCOR5) or pyridyl, opt. substd. by 1-3, 1-4C alkyl; R5 = 1-8C alkyl; R3 = up to 8C alkyl (opt. unsatd.); benzyl, phenyl, thiophene, furan or naphthalene residue (all opt. substd. as above), or 3-7C cycloalkyl; R4 = H, 1-8C alkyl, metal cation, ammonium ion, phenyl, benzyl or 2,3-dihydroxypropyl. Also new are the intermediates of formula (III), (IV), (VI), (VII), (VIII), (IX) or (XII): Q-X-Y-CHO (III); Q-X-Y-CHOH-CH2-CO-CH2-COOR4 (IV); Q-Z; Z = -X-Y-CN (cpds. (VI)); -CHO (cpds. (VII)); -CH2OH (cpds. (VIII)); or COOR7 (cpds. (IX)); R4 = 1-8C alkyl; R7 = protecting gp.; Q = a gp. of formula (i).
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公开(公告)号：FI883250A0
公开(公告)日：1988-07-07
申请号：FI883250
申请日：1988-07-07
Applicant: HOECHST AG
Inventor： BERGMANN ANDREAS , BARTMANN WILHELM , BECK GERHARD , LAU HANS-HERMANN
IPC: C07D213/30 , A61K31/365 , A61K31/366 , A61K31/38 , A61K31/40 , A61K31/44 , A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/50 , A61P3/06 , A61P9/10 , C07C45/68 , C07C47/55 , C07C51/00 , C07C51/09 , C07C59/00 , C07C59/125 , C07C59/48 , C07C59/68 , C07C59/72 , C07C59/90 , C07C67/00 , C07C313/00 , C07C323/52 , C07C333/04 , C07D213/55 , C07D239/26 , C07D309/10 , C07D309/30 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/12 , C07D409/06 , C07D409/12 , C07D493/04 , C07D493/14 , C07F7/18 , C07H15/18 , C07D
Abstract: 3-Desmethyl-4-fluoromevalonic acid derivatives of the formula I and the corresponding dihydroxycarboxylic acid derivatives of the formula II … … in which R, X and Y have the meanings given, processes for the preparation of these compounds, their use as medicaments and pharmaceutical preparations are described. Novel intermediates for the preparation of the compounds of the formula I or formula II are additionally described.
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公开(公告)号：FI883249A0
公开(公告)日：1988-07-07
申请号：FI883249
申请日：1988-07-07
Applicant: HOECHST AG
Inventor： KESSELER KURT , BECK GERHARD , BARTMANN WILHELM , GRANZER ERNOLD
IPC: A61K31/44 , A61K31/365 , A61K31/4418 , A61K31/443 , A61K31/505 , A61P3/06 , A61P9/10 , C07D213/55 , C07D239/26 , C07D405/06 , C07D405/14 , C07F7/18 , C07D
Abstract: 3-Desmethylmevalonic acid derivatives of the formula I ( delta -lactone) or II (corresponding dihydroxycarboxylic acid derivative) … … in which A-B, Z, R , R , R and R have the meanings given, are used as medicaments.
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公开(公告)号：AU6741687A
公开(公告)日：1987-07-16
申请号：AU6741687
申请日：1987-01-08
Applicant: HOECHST AG
Inventor： RUGER WOLFGANG , URBACH HANSJORG , BARTMANN WILHELM , KAISER JOACHIM
IPC: A61K31/395 , A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/451 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/55 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , C07D211/18 , C07D211/22 , C07D211/48 , C07D211/58 , C07D211/70 , C07D215/20 , C07D215/22 , C07D215/227 , C07D215/26 , C07D217/02 , C07D217/04 , C07D217/06 , C07D223/04 , C07D223/12 , C07D225/02 , C07D241/04 , C07D243/08 , C07D295/073 , C07D295/08 , C07D295/088 , C07D295/092 , C07D295/096 , C07D401/12 , C07D295/12
Abstract: Compounds I … … where R is equal to cycloalkyl, alkenyl, cycloalkenyl, phenyl, … … where B, C, D and E are equal to methine or nitrogen and… B', C', D' and E' are equal to methylene, carbonyl or imino;… R is equal to phenyl or phenylalkyl;… A is equal to various amine radicals;… m is equal to 2, 3 or 4; and… n is equal to 1, 2, 3 or 4;… salts of these compounds I are also described. Compounds I and the salts are calcium antagonists.
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公开(公告)号：PH17809A
公开(公告)日：1984-12-14
申请号：PH27241
申请日：1982-05-05
Applicant: HOECHST AG
Inventor： BECK GERHARD , BARTMANN WILHELM , KNOLLE JOCHEN , RUPP RICHARD HELMUT
IPC: A61K31/40 , A61K31/4025 , A61P43/00 , C07D207/24 , C07D409/12 , A01N9/36 , A01N9/00
Abstract: The present invention relates to DELTA 1-pyrroline thiolactim ethers of the general formula I I which have a more specific action and/or a longer-lasting action than PGI2, and to a process for their preparation. The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.
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