中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

44 records (took 0.036 seconds)

    Substituted propane derivatives, process for their preparation and use of the compounds for the treatment of illnesses.
    31.
    发明专利
    Substituted propane derivatives, process for their preparation and use of the compounds for the treatment of illnesses. 未知

    公开(公告)号：GR3035592T3

    公开(公告)日：2001-06-29

    申请号：GR20010400436

    申请日：2001-03-16

    Applicant: HOECHST AG

    Inventor： SCHUBERT GERRIT DR ,  HEMMERLE HORST DR ,  BELOW PETER DR ,  HERLING ANDREAS DR ,  BURGER HANS-JOERG DR

    IPC: A61K31/415 ,  A61K31/4184 ,  A61K31/435 ,  C07D235/08 ,  A61P3/08 ,  A61P3/10 ,  C07D235/06 ,  C07D471/04

    Abstract: Propane derivs. of formula (I), and their salts, are new: D-B-A = opt. substd. propyl, omega -hydroxy- (1-4C)alkyl, OH, OT, phenyl or phenyl(1-3C)alkyl); R = CN, COOH (opt. protected), 1-4C alkanoyl, SO3T, SO3H, SO2NR R , PO(OH)2, PO(OH)(OT), PO(OT)2 or tetrazol-5-yl; R = 1-10C alkyl(R )n, O-(1-10C)alkyl(R )n, 2-10C alkenyl(R )n, O-(3-10C)alkenyl(R )n, 2-10C alkynyl(R )n, O-(3-10C)alkynyl(R )n, S-(1-10C)alkyl(R )n, etc. (all R gps. being opt. substd.); R , R = H, T, 1-4C alkanoyl or opt. substd. phenyl; or NR R = a 4-10 membered, satd. heterocyclic ring (in which one CH2 gp. is opt. replaced by O, S or NR ); R = H, T, phenyl or benzyl; X = (CH2)m, CH=CH, C IDENTICAL C, CH2OCH2, CH2SCH2 or CH2-N(R )-CH2; Y = (CH2)m, O, S or NR ; Z = (CH2)m, S, O, S-(1-10C)alkyl, O-(1-10C)alkyl, CH=CH, CH=CF, CH=CCl, CH=CBr, CH2CO, etc.; or when Y = O, the gp. C(O)ZR may be an opt. protected amino acid residue; n = 0, 1 or 2; m = 0-4; R , R = 1-10C alkyl, 3-8C cycloalkyl, or opt. substd. Ar; T = 1-4C alkyl; Ar = phenyl, naphthyl, phenanthryl, pyridyl, thienyl, furyl, pyrimidyl, indolyl, etc.

Patent Agency Ranking