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公开(公告)号：HUT55394A
公开(公告)日：1991-05-28
申请号：HU454289
申请日：1989-09-01
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06 , C07K5/12
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：HUT54504A
公开(公告)日：1991-03-28
申请号：HU496690
申请日：1990-08-10
Applicant: HOECHST AG
Inventor： LINZ WOLFGANG , SCHOELKENS BERNWARD , SCHOLZ WOLFGANG , WIEMER GABRIELE , URBACH HANSJOERG , HENNING RAINER , TEETZ VOLKER
Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.
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公开(公告)号：AU4095789A
公开(公告)日：1990-03-08
申请号：AU4095789
申请日：1989-09-01
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUGER WOLFGANG , LERCH ULRICH , URBACH HANSJORG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：FI894097A
公开(公告)日：1990-03-04
申请号：FI894097
申请日：1989-08-31
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG , HOCK FRANZ , WIEMER GABRIELE
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06 , C07D
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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公开(公告)号：DK435289D0
公开(公告)日：1989-09-01
申请号：DK435289
申请日：1989-09-01
Applicant: HOECHST AG
Inventor： NICKEL WOLF-ULRICH , HOCK FRANZ , WIEMER GABRIELE , HENNING RAINER , RUEGER WOLFGANG , LERCH ULRICH , URBACH HANSJOERG
IPC: A61K31/495 , A61P25/00 , A61P25/28 , C07D241/08 , C07D403/04 , C07D405/04 , C07D455/04 , C07D471/04 , C07D471/08 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D513/04 , C07K1/113 , C07K5/06
Abstract: The invention relates to compounds of the formula I (I) in which R1, R2 and R4 represent optionally substituted aliphatic, alicyclic, alicyclic-aliphatic, aromatic, araliphatic, heteroaromatic or heteroaromatic-aliphatic radicals, with R2, if not already covered by the above-mentioned definitions, denoting the side-chain, which is protected if necessary, of a naturally occurring alpha -amino acid, R4 can additionally represent R3 denotes an optionally substituted aliphatic, alicyclic, aromatic or araliphatic radical, or R3 and R4 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, agents containing these, and the use thereof as pharmaceuticals having a psychotropic action for the prophylaxis of disorders of the central nervous system, especially having a nootropic action for the treatment of cognitive dysfunctions.
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Patent Agency Ranking
公开(公告)号：ZA8709330B
公开(公告)日：1988-07-27
申请号：ZA8709330
申请日：1987-12-11
Applicant: HOECHST AG
Inventor： KUNSTMANN RUDOLF , RUDOLF KUNSTMANN , HOCK FRANZ , FRANZ HOCK , WIEMER GABRIELE , GABRIELE WIEMER
IPC: C07D209/14 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/451 , A61K31/495 , A61P25/18 , A61P25/28 , C07C231/00 , C07C231/02 , C07C237/04 , C07C237/20 , C07C237/22 , C07D209/16 , C07D211/14 , C07D211/30 , C07D211/70 , C07D295/14 , C07D295/15 , C07D307/66 , C07D307/82 , C07D333/20 , C07D333/58 , C07D , C07C
CPC classification number: C07D295/15 , C07D209/16 , C07D211/14 , C07D211/70
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公开(公告)号：DK651987A
公开(公告)日：1988-06-13
申请号：DK651987
申请日：1987-12-11
Applicant: HOECHST AG
Inventor： KUNSTMANN RUDOLF , HOCK FRANZ , WIEMER GABRIELE
IPC: C07D209/14 , A61K31/165 , A61K31/195 , A61K31/215 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/445 , A61K31/451 , A61K31/495 , A61P25/18 , A61P25/28 , C07C231/00 , C07C231/02 , C07C237/04 , C07C237/20 , C07C237/22 , C07D209/16 , C07D211/14 , C07D211/30 , C07D211/70 , C07D295/14 , C07D295/15 , C07D307/66 , C07D307/82 , C07D333/20 , C07D333/58 , C07C103/50 , C07C101/04 , C07C103/66 , C07D211/34 , C07D211/78
Abstract: Aminopropionic acid amides of the formula I in which A, X and Z have the meanings indicated, and their physiologically tolerable salts are used as medicaments in which these compounds in particular have nootropic action.
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公开(公告)号：NO306979B1
公开(公告)日：2000-01-24
申请号：NO903532
申请日：1990-08-10
Applicant: HOECHST AG
Inventor： LINZ WOLFGANG , SCHOELKENS BERNWARD , SCHOLZ WOLFGANG , WIEMER GABRIELE , URBACH HANSJOERG , HENNING RAINER , TEETZ VOLKER
IPC: A61K38/55 , A61P9/08 , A61P9/10 , A61P43/00 , C07C237/12 , C07K5/06 , A61K38/00 , C07K5/04 , C07K5/02
Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.
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公开(公告)号：NO932390L
公开(公告)日：1994-01-03
申请号：NO932390
申请日：1993-06-30
Applicant: HOECHST AG
Inventor： HEITSCH HOLGER , WIEMER GABRIELE , WAGNER ADALBERT , KLEEMANN HEINZ-WERNER
IPC: A61K31/40 , A61K31/00 , A61K31/41 , A61K31/415 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/54 , A61K31/55 , A61K45/00 , A61P9/08 , A61P9/10 , A61P25/28 , A61P37/00 , C07D207/32 , C07D233/84 , C07D233/90 , C07D255/02 , C07D257/04 , C07D403/10 , C07D471/04 , A61K31/33
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公开(公告)号：HU205008B
公开(公告)日：1992-03-30
申请号：HU496690
申请日：1990-08-10
Applicant: HOECHST AG
Inventor： LINZ WOLFGANG , SCHOELKENS BERNWARD , SCHOLZ WOLFGANG , WIEMER GABRIELE , URBACH HANSJOERG , HENNING RAINER , TEETZ VOLKER
Abstract: The invention relates to a method for the treatment of cardiac and of vascular hypertrophy and hyperplasia by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I (I) in which n is 1 or 2, R, R1, R2 and R3 are identical or different and each is hydrogen or an organic radical, and R4 and R5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention additionally relates to angiotensin converting enzyme inhibitors and to agents containing these for administration for the treatment of the abovementioned diseases.
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