Nanofluidische, biochemische Sensoren auf der Grundlage von oberflächenladungsmoduliertem Ionenstrom

    公开(公告)号:DE112012003289T5

    公开(公告)日:2014-05-08

    申请号:DE112012003289

    申请日:2012-08-07

    Applicant: IBM

    Abstract: Biologische und chemische Sensoren auf der Grundlage von Änderungen in der Oberflächenladung in einer Pore oder einem Kanal wie zum Beispiel einer Nanopore oder einem Nanokanal werden eingesetzt, um Zielanalyten in einer Elektrolytlösung mit einer geringen Ionenkonzentration zu erfassen. Rezeptoren innerhalb der Pore oder des Kanals fangen einen Zielanalyten ein und verursachen dadurch eine Änderung in der Oberflächenladung, die sich auf den Ionenleitwert auswirkt. Die Änderung im Ionenleitwert wird erfasst, wodurch das Vorhandensein des Zielanalyten bewiesen wird. Ein Sekundärmarker kann in die Pore oder den Kanal eingebracht werden, damit er sich in bestimmten Fällen an einen eingefangenen Analyten bindet, um eine Änderung in der Oberflächenladung zu verursachen.

    EMBEDDING NANOTUBE INSIDE NANOPORE FOR DNA TRANSLOCATION

    公开(公告)号:CA2847580A1

    公开(公告)日:2013-03-14

    申请号:CA2847580

    申请日:2012-09-06

    Applicant: IBM

    Abstract: A technique for embedding a nanotube in a nanopore is provided. A membrane separates a reservoir into a first reservoir part and a second reservoir part, and the nanopore is formed through the membrane for connecting the first and second reservoir parts. An ionic fluid fills the nanopore, the first reservoir part, and the second reservoir part. A first electrode is dipped in the first reservoir part, and a second electrode is dipped in the second reservoir part. Driving the nanotube into the nanopore causes an inner surface of the nanopore to form a covalent bond to an outer surface of the nanotube via an organic coating so that the inner surface of the nanotube will be the new nanopore with a super smooth surface for studying bio-molecules while they translocate through the nanotube.

    35.
    发明专利
    未知

    公开(公告)号:DE3878393D1

    公开(公告)日:1993-03-25

    申请号:DE3878393

    申请日:1988-09-09

    Applicant: IBM

    Abstract: An improved apparatus and process are described in which metal images are transferred to a softenable receiving layer (32) using commercially available multi-stylus recording heads (10). The transfer medium is comprised of a resistive layer (16) and a thin metal layer (14) thereon. Electrical currents are provided by the recording styli (18) of the multi-stylus recording head. Localized electrical currents in the resistive layer (16) provide sufficient heat in the metal layer (14) to soften regions of a meltable receiving layer (32) when it is brought into contact with said heated metal layer. Metal imaging for use in printed circuit board manufacture and in formation of printing masters can be transferred by this technique.

    37.
    发明专利
    未知

    公开(公告)号:DE3671861D1

    公开(公告)日:1990-07-19

    申请号:DE3671861

    申请日:1986-10-23

    Applicant: IBM

    Abstract: The present invention relates to a resistive ribbon (10), for use in a resistive ribbon thermal transfer printing process, of the type which comprises a resistive layer (12) which produces localised heating to effect printing when an electric current is passed therethrough, a thermally fusible ink layer (18) capable of being melted when heated by the localised heating in the resistive layer, and a current return layer (16) of an electrically conductive material, located between the resistive layer (12) and the ink layer (18) and through which the electrical current passes. A ribbon in accordance with the invention is characterised in that the resistive layer (12) includes a phase-separated surface region (14) located adjacent the current return layer (16) and imparting enhanced mechanical and thermal properties to the resistive layer (12).

    Nanofluidic biochemical sensors based on surface charge modulated ion current

    公开(公告)号:GB2508114A

    公开(公告)日:2014-05-21

    申请号:GB201403414

    申请日:2012-08-07

    Applicant: IBM

    Abstract: Biological and chemical sensors based on surface charge changes in a pore or channel, such as a nanopore or nanochannel, are employed to detect targeted analytes in an electrolyte solution having a low ion concentration. Receptors within the pore or channel capture a targeted analyte, causing a change in surface charge that affects ionic conductance. The change in ionic conductance is detected, evidencing the presence of the targeted analyte. A secondary tag may be introduced to the pore or channel for binding with a captured analyte in certain circumstances for causing a change in the surface charge.

    Oxidation of graphene and carbon nanotubes

    公开(公告)号:GB2498054B

    公开(公告)日:2014-03-12

    申请号:GB201221175

    申请日:2012-11-26

    Applicant: IBM

    Abstract: A process comprises combining a Ce (IV) salt with a carbon material comprising CNT or graphene wherein the Ce (IV) salt is selected from a Ce (IV) ammonium salt of a nitrogen oxide acid and is dissolved in a solvent comprising water. The process is conducted under conditions to substantially oxidize the carbon material to produce an oxidized material that is substantially non-conducting. After the oxidation, the Ce (IV) is substantially removed from the oxidized material. This produces a product made by the process. An article of manufacture comprises the product on a substrate. The oxidized material can be formed as a pattern on the substrate. In another embodiment the substrate comprises an electronic device with the oxidized material patterning non-conductive areas separate from conductive areas of the non-oxidized carbon material, where the conductive areas are operatively associated with the device.

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