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公开(公告)号：JP2003172878A
公开(公告)日：2003-06-20
申请号：JP2002349926
申请日：2002-12-02
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , STORZ RAFAEL
Abstract: PROBLEM TO BE SOLVED: To provide a microscope objective lens which is structurally compact and makes rapid focusing or rapid scanning of a sample in an optical axis (z scanning) possible. SOLUTION: A microscope objective lens having an objective lens housing and including a plurality of lenses is disclosed and the lens is slidably arranged within the objective lens housing for focusing. Further, the microscope and method for imaging the sample are disclosed. COPYRIGHT: (C)2003,JPO
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32.发明专利
公开(公告)号：JP2002333580A
公开(公告)日：2002-11-22
申请号：JP2002067784
申请日：2002-03-13
Applicant: LEICA MICROSYSTEMS
Inventor： BIRK HOLGER , ENGELHARDT JOHANN
Abstract: PROBLEM TO BE SOLVED: To provide a method capable of easily regulating a beam path within an optical system. SOLUTION: The light beam (1) of the microscope (15) is inputted and coupled to a regulating device (7) of the light beam (1) at a prescribed position and at this time the inputted and coupled light beam (9) is formed within the device (70). The inputted and coupled light beam (9) is deflected to at least two photodetectors (10 and 22). The photodetectors (10 and 22) respectively have the different distances from the prescribed positions and the deviation between the inputted and coupled light beam (9) and a target position (72) is detected from the electric signals of the photodetectors (10 and 20) and an optical component (76) is regulated to bring the inputted and coupled light beam (9) to the target position (72) across at least one regulating element (78).
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33.发明专利
公开(公告)号：JP2002196252A
公开(公告)日：2002-07-12
申请号：JP2001348265
申请日：2001-11-14
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , HOFMANN JUERGEN
Abstract: PROBLEM TO BE SOLVED: To provide a light source device for illumination in scanning microscopic inspection which is stable, is easily adjustable and can realizes high resolution at a low cost and a scanning microscope. SOLUTION: The light source device for illumination in scanning microscopic inspection and the scanning microscope a) have an electromagnetic energy source (3) which emits a ray (17) of one wavelength, b) are placed with a means (5) for forming two split rays (19 and 21) by spatially splitting the ray (17) behind the electromagnetic energy source (3) and c) are disposed with an intermediate element (9) for changing the wavelength at least at one split ray (21).
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公开(公告)号：JP2002072160A
公开(公告)日：2002-03-12
申请号：JP2001184471
申请日：2001-06-19
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN
Abstract: PROBLEM TO BE SOLVED: To stabilize temperature of optical parts for a scanning microscope. SOLUTION: The present invention can keep the temperature of the parts constant stably and simply as much as possible and require less space while keeping the number of assemblies to be increased low as much as possible. The present invention relates to a method and a device for stabilizing the temperature of the optical parts for, preferably, the scanning microscope, specifically a confocal scanning microscope, especially optically active parts, electro-optical parts or acoustic-optical parts, and is characterized in that energy interacting with the parts works for stabilization.
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公开(公告)号：JP2002062262A
公开(公告)日：2002-02-28
申请号：JP2001183691
申请日：2001-06-18
Applicant: LEICA MICROSYSTEMS
Inventor： STORZ RAFAEL , ENGELHARDT JOHANN
IPC: G01N21/64 , G01J1/42 , G01N21/01 , G02B6/02 , G02B6/122 , G02B6/255 , G02B21/00 , G02B21/06 , G02B21/36 , G02B27/00 , H01S3/00 , H01S3/16
Abstract: PROBLEM TO BE SOLVED: To make an interlaced photon generated at high efficiency. SOLUTION: A fine-structured optical element 11 for generating the interlaced photon is arranged between a light source 3 and an objective lens 31. The interlaced photon is propagated inside a beam 15 on the inside and the outside of the fine-structured optical element.
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Patent Agency Ranking
公开(公告)号：JP2001356274A
公开(公告)日：2001-12-26
申请号：JP2001105913
申请日：2001-04-04
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , BEWERSDORF JOERG , GUGEL HILMAR , HOFFMANN JUERGEN
Abstract: PROBLEM TO BE SOLVED: To provide a double confocal scanning type microscope which can realize at least almost theoretically realizable resolution especially in association with polychromatic fluorescent use. SOLUTION: This invention relates to the double confocal scanning type microscope having an irradiation beam passage 2 of at least one light source 3 and a detection beam passage 4 of at least one detector 5. In particular, optical characteristics of elements 6, 10, 13 and 14 arranged at the beam passages are mutually adjusted so that accumulated aberration is at least as large as theoretically realizable resolution as to an optical axis 33 and/or at least one surfaces 18, 19 and 20 of a sample region.
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公开(公告)号：JP2001249279A
公开(公告)日：2001-09-14
申请号：JP2000356332
申请日：2000-11-22
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN
Abstract: PROBLEM TO BE SOLVED: To provide a scanner for a laser scanning microscope which can scan a large specimen at sufficient speed. SOLUTION: The specimen housing device 1 of a confocal laser scanning microscope 2 is alternately rotatable around a first axis line 4 by a rotator 3, and a scanning is performed when the specimen housing device 1 rotates around a second axis line 6 together with the rotator 3. The first axis line 4 and the second axis line 6 are disposed nearly parallel.
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公开(公告)号：JP2001249077A
公开(公告)日：2001-09-14
申请号：JP2001017050
申请日：2001-01-25
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN
Abstract: PROBLEM TO BE SOLVED: To prevent the superposition of fluorescences generated from a plurality of specimen points at the positions of detection elements. SOLUTION: In an apparatus for detecting fluorescences from a plurality of sample points 2, especially, from minute gene points or micro-points, the specimen points 2 are arranged on a slide 1. This apparatus includes at least one light source for illuminating the specimen points at the same time using exciting light and the detection elements 3 for detecting fluorescences from the individual specimen points at the same time. The interval (d) between the specimen points 2 and the detection elements 3 individually alloted thereto is selected so as to become as narrow as possible.
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公开(公告)号：JP2001235666A
公开(公告)日：2001-08-31
申请号：JP2001017796
申请日：2001-01-26
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN
Abstract: PROBLEM TO BE SOLVED: To constitute and improve a device to position an optical element in an optical path so that plural optical elements are easily, quickly and accurately exchanged. SOLUTION: A holder 3 is guided to a guide block 5 which is installed at the optical path 2 and possesses the path 4 of the optical path 2 as a magazine slider 3, and a constituting member 1 is provided with an optical activating surface 6 that is positioned within a plane 8 in parallel with the guide surface 7 of the magazine slider 3.
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公开(公告)号：JP2001004923A
公开(公告)日：2001-01-12
申请号：JP2000158428
申请日：2000-05-29
Applicant: LEICA MICROSYSTEMS
Inventor： ENGELHARDT JOHANN , KIERSCHKE KLAUS
Abstract: PROBLEM TO BE SOLVED: To realize the reciprocation without the tilt of components to be positioned with simple means in a device for precisely positioning, in particular, the objective lens or the objective lens revolver of a microscope in a vertical direction. SOLUTION: A lever constituting part 3 directly acts on a rotation part 5. The component 1 is coupled with the rotation part 5 through a flexible element. A coupling part 6 is constituted to form a suspending part for the component part 1 so as to change the position of the component 1 by making the flexible coupling part 6 roll on the rotation part 5 with the rotation of the rotation part 5 and reciprocate (3) the component 1 in such a case.
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