公开(公告)号：MA32280B1

公开(公告)日：2011-05-02

申请号：MA33300

申请日：2010-11-01

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: L'invention concerne des composés de formule (i-ii) et des tautomères, des sels, ou des stéréo-isomères de ceux-ci, qui sont acceptables du point de vue pharmaceutique, et qui constituent des inhibiteurs de syk kinases et/ou de janus kinases. L'invention concerne également des intermédiaires utilisés dans la fabrication de tels composés, la préparation d'un tel composé, des compositions pharmaceutiques contenant un tel composé, des procédés d'inhibition de l'activité de syc kinases et/ou de janus kinases, des procédés d'inhibition d'agrégation plaquettaire, et des procédés pour prévenir ou pour traiter un certain nombre de troubles au moins partiellement médiés par l'activité de syc kinases et/ou de janus kinases, comme une thrombose non voulue ou un lymphome non hodgkinien.

公开(公告)号：SV2010003705A

公开(公告)日：2011-03-23

申请号：SV2010003705

申请日：2010-10-15

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  VENKATARAMANI CHANDRASEKAR ,  HUANG WOLIN ,  MEHROTRA MUKUND ,  SONG YONGHONG ,  XU QING ,  BAUER SHAWN M ,  PANDEY ANJALI ,  KANE BRIAN ,  ROSE JACK W

IPC: A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: COMPUESTOS DE FORMULA I-V Y TAUTÓMEROS CORRESPONDIENTES O SALES FARMACÉUTICAMENTE ACEPTADAS, ESTERES Y PROFÁRMACOS CORRESPONDIENTES QUE ACTÚAN COMO INHIBIDORES DE QUINASA SYK. LA PRESENTE INVENCIÓN TAMBIÉN ESTA DIRIGIDA A INTERMEDIARIOS UTILIZADOS EN LA ELABORACIÓN DE DICHOS COMPUESTOS, LA PREPARACIÓN DE DICHOS COMPUESTOS, COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN DICHOS COMPUESTOS, MÉTODOS PARA INHIBIR LA ACTIVADA DE QUINASA SYK, MÉTODOS PARA INHIBIR LA ACUMULACIÓN DE PLAQUETAS Y MÉTODOS PARA PREVENIR O TRATAR UNA CANTIDAD DE ENFERMEDADES MEDIADAS AL MENOS PARCIALMENTE POR ACTIVIDAD DE QUINASA SYK, COMO ENFERMEDADES CARDIOVASCULARES, ENFERMEDADES INFLAMATORIAS, ENFERMEDADES AUTOINMUNES Y TRASTORNOS PROLIFERATIVOS DE CÉLULAS. LA FORMULA (I) Y1 ES SELECCIONADA DEL GRUPO QUE CONSISTE EN: (A) Y (B), Z ES 0 O S, DL ES SELECCIONADA DEL GRUPO QUE CONSISTE EN: (A) FENILO SUSTITUIDO POR UN GRUPO, R5 (B) NAFTILO (C) C3-8CICLOALQUILO (D) HETEROARILO (E) HETEROCICLOLO

公开(公告)号：ZA200902082B

公开(公告)日：2010-03-31

申请号：ZA200902082

申请日：2009-03-25

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K20100101 ,  A61P20100101 ,  C07D20100101

公开(公告)号：PL1668002T3

公开(公告)日：2010-02-26

申请号：PL04789522

申请日：2004-09-29

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  HUANG WOLIN ,  PANDEY ANJALI ,  BAUER SHAWN M ,  ZHANG XIAOMING ,  JIA ZHAOZHONG J

IPC: C07D409/12 ,  A61K20060101 ,  A61K31/517 ,  A61P7/02 ,  C07D409/14

公开(公告)号：CA2960692A1

公开(公告)日：2009-12-03

申请号：CA2960692

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present specification is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present specification is also directed to intermediates used in making such compounds, the preparation of such a compound, methods for inhibition of syk and/or JAK kinase activity, methods for inhibition of the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. The present specification is also directed to pharmaceutical compositions containing such a compound and which are formulated for topical administration.

公开(公告)号：SG10201805392YA

公开(公告)日：2018-08-30

申请号：SG10201805392Y

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  ROSE JACK ,  BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI

Abstract: 1,2,4-TRIAZINE-6-CARBOXAMIDE KINASE INHIBITORS Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity. No Figure

公开(公告)号：PL2321283T3

公开(公告)日：2017-01-31

申请号：PL09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：AU2013277476B2

公开(公告)日：2016-12-15

申请号：AU2013277476

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  ROSE JACK ,  BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI

IPC: C07D403/12 ,  A01N43/64 ,  A01N43/707 ,  A61K31/53 ,  C07D253/075 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：SG11201408232RA

公开(公告)日：2015-01-29

申请号：SG11201408232R

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  ROSE JACK ,  BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI

IPC: A01N43/64 ,  A01N43/707 ,  A61K31/53

Abstract: Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

公开(公告)号：CA2877469A1

公开(公告)日：2013-12-27

申请号：CA2877469

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  SRAN ARVINDER ,  BAUER SHAWN M ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  PANDEY ANJALI

IPC: A61K31/16 ,  A61K31/435 ,  A61K31/44 ,  C07D401/02

Abstract: Provided are picolinamide compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.