公开(公告)号：MX2010011464A

公开(公告)日：2014-06-16

申请号：MX2010011464

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: La presente invención se dirige a compuestos de la Fórmula I-II y tautómeros, sales o estereoisómeros farmacéuticamente aceptables de la misma que son inhibidores de syk y/o JAK quinasas. La presente invención también se dirige a intermediarios usados para realizar dichos compuestos, a la preparación de dicho compuesto, composiciones farmacéuticas que contienen dicho compuesto, métodos de inhibición de syk y/o JAK quinasa, métodos para la inhibición de agregación de plaquetas, y métodos para evitar o tratar una cantidad de enfermedades mediadas, al menos en parte, por la actividad syk y/o JAK quinasa, como por ejemplo trombosis y Linfoma no- Hodgkin.

公开(公告)号：MX315135B

公开(公告)日：2013-11-07

申请号：MX2012011444

申请日：2010-10-15

Applicant: PORTOLA PHARM INC

Inventor： MEHROTRA MUKUND ,  HUANG WOLIN ,  SONG YONGHONG ,  JIA ZHAOZHONG J ,  XU QING ,  VENKATARAMANI CHANDRASEKAR ,  BAUER SHAWN M ,  PANDEY ANJALI ,  ROSE JACK W ,  KANE BRIAN

公开(公告)号：ZA201007046B

公开(公告)日：2013-09-25

申请号：ZA201007046

申请日：2010-10-04

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  HUANG WOLIN ,  SONG YONGHONG ,  BAUER SHAWN M ,  ROSE JACK W ,  VENKATARAMANI CHANDRASEKAR ,  MEHROTRA MUKUND ,  XU QING ,  PANDEY ANJALI ,  KANE BRIAN

IPC: A61K20060101 ,  A61P20060101 ,  C07D20060101

Abstract: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.

公开(公告)号：AU2006311795B2

公开(公告)日：2013-01-17

申请号：AU2006311795

申请日：2006-11-03

Applicant: PORTOLA PHARM INC

Inventor： GRANT CRAIG M ,  ZHANG XIAOMING ,  CANNON HILARY ,  MEHROTRA MUKUND ,  HUANG WOLIN ,  SCARBOROUGH ROBERT M

IPC: C07D257/04 ,  A61K31/44 ,  A61K31/5513

Abstract: The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.

公开(公告)号：ES2380814T3

公开(公告)日：2012-05-18

申请号：ES06827506

申请日：2006-11-03

Applicant: PORTOLA PHARM INC

Inventor： HUANG WOLIN ,  MEHROTRA MUKUND ,  ZHANG XIAOMING ,  CANNON HILARY ,  GRANT CRAIG M ,  SCARBOROUGH ROBERT M

IPC: C07D409/12 ,  A61K31/517 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10

Abstract: Un compuesto que tiene la fórmula: **Fórmula** o una sal farmacéuticamente aceptable o hidrato del mismo.

公开(公告)号：AT540034T

公开(公告)日：2012-01-15

申请号：AT06827506

申请日：2006-11-03

Applicant: PORTOLA PHARM INC

Inventor： HUANG WOLIN ,  MEHROTRA MUKUND ,  ZHANG XIAOMING ,  CANNON HILARY ,  GRANT CRAIG M ,  SCARBOROUGH ROBERT M

IPC: C07D409/12 ,  A61K31/517 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10

Abstract: The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.

公开(公告)号：AU2009251863A2

公开(公告)日：2011-06-09

申请号：AU2009251863

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  MEHROTRA MUKUND ,  XU QING ,  ROSE JACK W ,  SONG YONGHONG ,  VENKATARAMANI CHANDRASEKAR ,  JIA ZHAOZHONG J ,  BAUER SHAWN M ,  HUANG WOLIN

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.

公开(公告)号：DE60238086D1

公开(公告)日：2010-12-02

申请号：DE60238086

申请日：2002-07-25

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  JANTZEN HANS-MICHAEL ,  HUANG WOLIN ,  SEDLOCK DAVID M ,  MARLOWE CHARLES K ,  KANE-MAGUIRE KIM A

IPC: C07D239/96 ,  C07D409/14 ,  A61K31/16 ,  A61K31/175 ,  A61K31/381 ,  A61K31/4035 ,  A61K31/4196 ,  A61K31/4725 ,  A61K31/519 ,  A61K31/54 ,  A61K31/64 ,  A61P7/02 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/14 ,  A61P43/00 ,  C07D209/48 ,  C07D213/70 ,  C07D239/22 ,  C07D239/50 ,  C07D333/34 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04 ,  C07D495/04 ,  C07D521/00

公开(公告)号：AU2004278030C1

公开(公告)日：2010-12-02

申请号：AU2004278030

申请日：2004-09-29

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  ZHANG XIAOMING ,  BAUER SHAWN M ,  HUANG WOLIN ,  PANDEY ANJALI ,  JIA ZHAOZHONG J

IPC: C07D409/12 ,  A61K20060101 ,  A61K31/517 ,  A61P7/02 ,  C07D409/14

Abstract: 2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds having the formula: wherein R is a member selected from the group consisting of H and C 1-6 alkyl; R 1 is a member selected from the group consisting of H, C 1-6 alkyl, C 1-6 haloalkyl, C 3-5 cycloalkyl and C 3-5 cycloalkyl-alkyl; R 2 is a member selected from the group consisting of H, halogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 alkoxy, cyano and -C(O)R 2a , wherein R 2a is a member selected from the group consisting of C 1-6 alkoxy and (C 1-6 alkyl) 0-2 amino; L is a 1 to 3 carbon linking group selected from the group consisting of -CH 2 -, -CH(CH 3 )-, -CH 2 CH 2 -, -CH 2 CH(CH 3 )- and -CH 2 CH 2 CH 2 -; L 1 is a linking group selected from the group consisting of a bond and -CH 2 -; L 2 is a linking group selected from the group consisting of a bond, -NH- and -CH 2 -; and Ar 1 is an aromatic ring selected from the group consisting of benzene, pyridine and pyrimidine; are provided. The compounds are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.

公开(公告)号：AU2009251863A1

公开(公告)日：2009-12-03

申请号：AU2009251863

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： PANDEY ANJALI ,  MEHROTRA MUKUND ,  XU QING ,  ROSE JACK W ,  SONG YONGHONG ,  VENKATARAMANI CHANDRASEKAR ,  JIA ZHAOZHONG J ,  BAUER SHAWN M ,  HUANG WOLIN

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as cardiovascular disease, inflammatory disease, autoimmune disease and cell proliferative disorder, thrombosis, allergy, asthma, rheumatoid arthritis, leukemia, or non-Hodgkin's lymphoma.