公开(公告)号：PL1668002T3

公开(公告)日：2010-02-26

申请号：PL04789522

申请日：2004-09-29

Applicant: PORTOLA PHARM INC

Inventor： SCARBOROUGH ROBERT M ,  HUANG WOLIN ,  PANDEY ANJALI ,  BAUER SHAWN M ,  ZHANG XIAOMING ,  JIA ZHAOZHONG J

IPC: C07D409/12 ,  A61K20060101 ,  A61K31/517 ,  A61P7/02 ,  C07D409/14

公开(公告)号：CA2960692A1

公开(公告)日：2009-12-03

申请号：CA2960692

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present specification is directed to compounds of formula I-II and pharmaceutically acceptable tautomers, salts, or stereoisomers thereof which are inhibitors of syk and/or JAK kinase. The present specification is also directed to intermediates used in making such compounds, the preparation of such a compound, methods for inhibition of syk and/or JAK kinase activity, methods for inhibition of the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma. The present specification is also directed to pharmaceutical compositions containing such a compound and which are formulated for topical administration.

公开(公告)号：MXPA06003618A

公开(公告)日：2006-08-11

申请号：MXPA06003618

申请日：2004-09-29

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J

IPC: A61K31/517 ,  A61K20060101 ,  A61P7/02 ,  C07D409/12 ,  C07D409/14 ,  A61P07/02

Abstract: Compuestos 2,4-dioxo-3-quinazolinilaril sulfonilurea se proporcionan, que son utiles para la inhibicion de agregacion de plaquetas ADP, particularmente en el tratamiento de trombosis y condiciones o desordenes relacionadas con trombosis.

公开(公告)号：CA2876945C

公开(公告)日：2021-07-27

申请号：CA2876945

申请日：2013-06-14

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  KANE BRIAN ,  ROSE JACK ,  BAUER SHAWN M ,  SONG YONGHONG ,  XU QING ,  PANDEY ANJALI

IPC: C07D253/075 ,  A61K31/53 ,  A61K31/5377 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D495/04

Abstract: Provided are triazine compounds of Formula I for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity. (see formula I)

公开(公告)号：CA2816219C

公开(公告)日：2019-10-29

申请号：CA2816219

申请日：2011-11-01

Applicant: PORTOLA PHARM INC

Inventor： JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D213/82 ,  A61K31/455 ,  A61P35/00 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D495/04

Abstract: The present application is directed to compounds of the following formula and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. Also disclosed are intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma. (see above formula)

公开(公告)号：HUE031638T2

公开(公告)日：2017-07-28

申请号：HUE09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: A61P9/00 ,  A61P35/00

公开(公告)号：EA026939B1

公开(公告)日：2017-06-30

申请号：EA201491013

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: A61K31/4965

Abstract: Обеспечиваютсяпиразиновыесоединенияформулы (I)где X, V, R, Rтакиекакуказанов формулеизобретения, илиегофармацевтическиприемлемаясольдляингибирования Syk киназы, промежуточныесоединения, используемыедляполучениятакихсоединений, способыихполучения, включающиеихфармацевтическиекомпозиции, способыингибирования Syk киназнойактивностии способылечениясостояний, опосредованных, поменьшеймеречастично, киназнойактивностью Syk.

公开(公告)号：SI2321283T1

公开(公告)日：2017-01-31

申请号：SI200931540

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/00 ,  A61K31/00 ,  A61P9/00 ,  A61P35/00 ,  C07D401/00 ,  C07D403/00 ,  C07D413/00 ,  C07D417/00

公开(公告)号：DK2321283T3

公开(公告)日：2016-10-31

申请号：DK09755219

申请日：2009-04-16

Applicant: PORTOLA PHARM INC

Inventor： BAUER SHAWN M ,  JIA ZHAOZHONG J ,  SONG YONGHONG ,  XU QING ,  MEHROTRA MUKUND ,  ROSE JACK W ,  HUANG WOLIN ,  VENKATARAMANI CHANDRASEKAR ,  PANDEY ANJALI

IPC: C07D239/48 ,  A61K31/506 ,  A61P9/00 ,  A61P35/00 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：AU2012340555B2

公开(公告)日：2016-10-20

申请号：AU2012340555

申请日：2012-11-23

Applicant: PORTOLA PHARM INC

Inventor： SONG YONGHONG ,  XU QING ,  JIA ZHAOZHONG J ,  KANE BRIAN ,  BAUER SHAWN M ,  PANDEY ANJALI

IPC: C07D241/28 ,  A61K31/4965

Abstract: Provided are pyrazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibition Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.