公开(公告)号：ZA200202220B

公开(公告)日：2002-10-10

申请号：ZA200202220

申请日：2002-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  C07D ,  A61K ,  A61P

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：AU2324202A

公开(公告)日：2002-09-19

申请号：AU2324202

申请日：2002-03-12

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUTIN JEAN-ALBERT ,  ROUSSEAU ANNE ,  BOUSSARD MARIE-FRANCOISE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  C07D209/56 ,  A61K31/404

Abstract: Compound of formula (I):wherein:R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyl or carboxy,R7 represents hydrogen, hydroxy, alkoxy, arylalkoxy, acyloxy or arylcarbonyloxy group,or one of R1 to R8, together with another of R1 to R8 adjacent to it, forms an alkylenedioxy,its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

公开(公告)号：CA2376876A1

公开(公告)日：2002-09-12

申请号：CA2376876

申请日：2002-03-11

Applicant: SERVIER LAB

Inventor： DELAGRANGE PHILIPPE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  BOUSSARD MARIE-FRANCOISE ,  WIERZBICKI MICHEL

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  C07D209/44 ,  A61K31/4035

Abstract: L'invention concerne de nouveaux composés répondant à la formule (1) : SEE FORMULA I dans laquelle R1, R2 R3, R4, R5, R6 et R8, identiques ou différents, représentent chacun un atome d'hydrogène ou un groupement alkyle, arylalkyle, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyle ou carboxy, R7 représente un atome d'hydrogène ou un groupement hydroxy, alkoxy, arylalkoxy, acyloxy ou arylcarbonyloxy, ou l'un des groupements R1 à R8 forme avec un autre groupement R1 à R8 contigu un groupement alkylènedioxy; sous réserve que l'un au moins des groupements R1 à R8 représente un groupement hydroxy, alkoxy, acyloxy ou arylcarbonyloxy, et les composés de formule (I) excluent la 1,3-diméthoxy-6H-isoindolo[2,1-a]indol-6-one. L'invention vise également les isomères optiques des composés de formule (I), ainsi que leur sels d'additio n à un acide ou à une base pharmaceutiquement acceptable. Les composés selon l'invention son t utiles à titre de médicaments pour le traitement des troubles du système mélatoninergique.

公开(公告)号：CY2173B1

公开(公告)日：2002-08-23

申请号：CY0000020

申请日：2000-05-30

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  VERBEUREN TONY ,  VALLEZ MARIE-ODILE ,  CANET EMMANUEL ,  YVES ROLLAND

IPC: A61K31/35 ,  A61K31/352 ,  A61P9/00 ,  A61P9/14 ,  A61P29/00 ,  C07D311/30 ,  C07D407/12 ,  C07D407/14 ,  C07H15/26

Abstract: Diosmetin derivs. of formula (I) and their diastereomers and/or enantiomers are new. R1 = H, propyl, allyl or 1,2-dideuteroallyl; R2 = H, propyl, allyl, propargyl, 2,3-dihydroxypropyl, (2,2-dimethyl- 1,3-dioxol-4-yl) methyl or 3-acetyloxy-2-hydroxypropyl; R3 = H, propyl, allyl or 1,2-dideuteroallyl; R4 = H, Me, propyl, allyl, propargyl, 2,3-dihydroxypropyl, (2,2-dimethyl- 1,3-dioxol-4-yl)methyl or COR4'; R5 = H, propyl, allyl or 1,2-dideuteroallyl; and R6 = H, Me, propyl, allyl, propargyl, 2,3-dihydroxypropyl, (2,2-dimethyl- 1,3-dioxol-4-yl)methyl, COR6' or a gp. of formula (i); R4', R6' = 1-5C alkyl or Ph; provided that at least one of R1-R6 is other than H; and if R1- R3 = H, then R4 = H.

公开(公告)号：NO20022891D0

公开(公告)日：2002-06-17

申请号：NO20022891

申请日：2002-06-17

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  FOURQUEZ JEAN-MARIE ,  LEVENS NIGEL ,  HUSSON-ROBERT BERNADETTE ,  NOSJEAN OLIVIER ,  BOULANGER MICHELLE

IPC: A61K31/16 ,  C07D295/18 ,  A61K31/397 ,  A61K31/40 ,  A61K31/403 ,  A61K31/426 ,  A61K31/4453 ,  A61K31/5375 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  C07C237/14 ,  C07D205/04 ,  C07D207/18 ,  C07D207/20 ,  C07D209/02 ,  C07D209/52 ,  C07D277/04 ,  C07D277/22 ,  C07D295/185 ,  C07D

Abstract: A compound of formula (I):wherein:represents an optionally substituted saturated carbon ring having from 4 to 8 ring members,R1 and R4, which may be identical or different, each represents hydrogen or acyl,R2 and R3, which may be identical or different, each represents hydrogen or alkyl,R5 and R6, which may be identical or different, each represents hydrogen or alkyl, or R5 and R6 together, with the nitrogen atom carrying them, form an optionally substituted nitrogen-containing heterocycle,stereoisomers thereof, and also addition salts thereof with a pharmaceutically acceptable acid.Medicinal products containing the same which are useful for treatment of glucose intolerance or of disorders associated with hyperglycaemia.

公开(公告)号：NO20021198D0

公开(公告)日：2002-03-11

申请号：NO20021198

申请日：2002-03-11

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D487/06 ,  A61K31/407 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D487/04 ,  C07D

Abstract: Compound of formula (I):wherein:R1, R2, R3, R4, R5, R6 and R8, which may be identical or different, each represents hydrogen, alkyl, arylalkyl, hydroxy, alkoxy, arylalkoxy, acyloxy, arylcarbonyloxy, carboxyalkyl or carboxy,R7 represents hydrogen, hydroxy, alkoxy, arylalkoxy, acyloxy or arylcarbonyloxy group,or one of R1 to R8, together with another of R1 to R8 adjacent to it, forms an alkylenedioxy,its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

公开(公告)号：AU2490297A

公开(公告)日：1998-01-08

申请号：AU2490297

申请日：1997-06-13

Applicant: SERVIER LAB

Inventor： TSOUDEROS YANNIS ,  DELOFFRE PASCALE ,  WIERZBICKI MICHEL

IPC: C07D333/38 ,  A61K31/19 ,  A61K31/38 ,  A61K31/381 ,  A61K33/00 ,  A61K33/24 ,  A61P19/02 ,  A61P43/00 ,  A61K31/185 ,  A61K33/14

Abstract: Use of strontium salts (I) in compositions for the prevention and treatment of arthrosis is new.

公开(公告)号：GEP20115342B

公开(公告)日：2011-12-12

申请号：GEAP2009011185

申请日：2009-03-25

Applicant: SERVIER LAB

Inventor： SANSILVESTRI-MOREL PATRICIA ,  WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12

Abstract: Compounds of the formula (I), (I) wherein R1, R2 and R3 have the values indicated in the claims; a method for its production and use thereof for prevention or treatment of chronic vein diseases.

公开(公告)号：HRP20110361T1

公开(公告)日：2011-06-30

申请号：HRP20110361

申请日：2011-05-16

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRAN OISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANÇOIS

IPC: C07D311/30 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  C07D407/12 ,  C07H15/26

Abstract: Diosmetin derivatives (I), are new. Diosmetin derivatives of formula (I), are new. R1-R3 : H or (2S,3S,4R,5S)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid moiety. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Antidiabetic; Hypotensive; Antiarteriosclerotic; Analgesic; Antianginal; Anorectic; Cerebroprotective. MECHANISM OF ACTION : None given.

公开(公告)号：SI2107055T1

公开(公告)日：2011-05-31

申请号：SI200930019

申请日：2009-03-31

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE FRANCOISE ,  VERBEUREN TONY ,  SANSILVESTRI-MOREL PATRICIA ,  RUPIN ALAIN ,  PAYSANT JEROME ,  LEFOULON FRANCOIS

IPC: C07D311/00 ,  A61K31/352 ,  A61K31/7012 ,  A61P9/00 ,  C07D407/00 ,  C07H15/00