公开(公告)号：NZ595153A

公开(公告)日：2014-05-30

申请号：NZ59515310

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR ,  VAN GOOR FREDRICK F

IPC: C07D215/233 ,  A61K31/365 ,  C07D215/56 ,  C07D307/83

Abstract: The disclosure provides a process for the preparation of a substituted 4-Hydroxy-N-phenylquinoline-3-carboxamide derivative of Formula 1; comprising coupling a substituted 4-Hydroxyquinoline-3-carboxylic acid derivative of Formula 2; with an substituted aniline of Formula 3; in the presence of a coupling agent. The compounds of formula I being useful as cystic fibrosis transmembrane conductance regulators.

公开(公告)号：AU2010327993A1

公开(公告)日：2012-07-12

申请号：AU2010327993

申请日：2010-12-10

Applicant: VERTEX PHARMA

Inventor： SHETH URVI ,  FANNING TEV T D ,  NUMA MEHDI ,  BINCH HAYLEY ,  HURLEY DENNIS JAMES ,  ZHOU JINGLAN ,  HADIDA RUAH SARA S ,  HAZLEWOOD ANNA R ,  SILINA ALINA ,  VAIRAGOUNDAR RAJENDRAN ,  VAN GOOR FREDRICK F ,  GROOTENHUIS PETER DIEDERIK JAN ,  BOTFIELD MARTYN C

IPC: C07D215/56 ,  A61K31/4709 ,  A61P11/00 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/08

Abstract: The present invention relates to 4 -oxo- lH-quinoline- 3 carboxamides as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present Invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：CA2984994A1

公开(公告)日：2010-09-23

申请号：CA2984994

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/56

Abstract: The invention provides a process for the preparation of a compound of Formula 1; (See Formula 1) comprising coupling a carboxylic acid of Formula 2; (See Formula 2) with an aniline of Formula 3; (See Formula 3) in the presence of a coupling agent.

公开(公告)号：DE60326742D1

公开(公告)日：2009-04-30

申请号：DE60326742

申请日：2003-10-02

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID J ,  BOTFIELD MARTYN C ,  ECKARD OTTOW

IPC: C07D211/60 ,  A61K31/496 ,  A61P25/28 ,  C07D207/16

Abstract: The present invention relates to piperazine and piperidine derivatives, which are especially useful for treating or preventing neuronal damage, particularly damage associated with neurological diseases. These compounds are also useful for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage or for stimulating nerve growth.

公开(公告)号：CA2500672A1

公开(公告)日：2004-04-15

申请号：CA2500672

申请日：2003-10-02

Applicant: VERTEX PHARMA

Inventor： LAUFFER DAVID J ,  BOTFIELD MARTYN C ,  ECKARD OTTOW

IPC: A61P25/28 ,  C07D207/16 ,  C07D211/60 ,  A61K31/496

Abstract: The present invention relates to piperazine and piperidine derivatives, whic h are especially useful for treating or preventing neuronal damage, particular ly damage associated with neurological diseases. These compounds are also usefu l for stimulating nerve growth. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage of for stimulating nerve growth.

公开(公告)号：DK2408749T3

公开(公告)日：2018-08-13

申请号：DK10710748

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： YANG XIAOQING ,  HADIDA RUAH SARA S ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233 ,  A61K31/47 ,  A61P3/00

公开(公告)号：CY1119796T1

公开(公告)日：2018-06-27

申请号：CY171101344

申请日：2017-12-22

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANA ,  TRUDEAU MARTIN ,  ROPER STEFANIE ,  RYAN MICHAEL ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GROOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

Abstract: ΗεφεύρεσηπαρέχειμίαμέθοδογιατηνπαρασκευήμίαςένωσηςΤύπου 1˙πουπεριλαμβάνεισύζευξηενόςκαρβοξυλικούοξέοςΤύπου 2 μεμίαανιλίνηΤύπου 3˙παρουσίαενόςπαράγοντασύζευξης.

公开(公告)号：HRP20171901T1

公开(公告)日：2018-02-23

申请号：HRP20171901

申请日：2017-12-07

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT LANGILLE BOBBIANA ,  TRUDEAU MARTIN ,  ROPER STEFANIE ,  RYAN MICHAEL ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GROOR FREDERICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：DK2821400T3

公开(公告)日：2018-01-02

申请号：DK14182117

申请日：2010-03-19

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  NEUBERT-LANGILLE BOBBIANA ,  TRUDEAU MARTIN ,  RYAN MICHAEL ,  YAP DAHRIKA MILFRED LAO ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GROOR FREDERICK F ,  BOTFIELD MARTYN C ,  LOOKER ADAM R ,  ROPER STEFANIE ,  ZLOKARNIK GREGOR

IPC: C07D215/233

公开(公告)号：AU2016244296A1

公开(公告)日：2016-11-03

申请号：AU2016244296

申请日：2016-10-13

Applicant: VERTEX PHARMA

Inventor： DEMATTEI JOHN ,  LOOKER ADAM R ,  NEUBERT-LANGILLE BOBBIANNA J ,  TRUDEAU MARTIN ,  ROEPER STEFANIE ,  RYAN MICHAEL P ,  GUERETTE DAHRIKA MILFRED LAO YAP ,  KRUEGER BRIAN R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  BOTFIELD MARTYN C ,  ZLOKARNIK GREGOR

IPC: C07D215/233

Abstract: The invention provides a process for the preparation of a compound of Formula 1, N H (Rx-X H R2 Formula 1 comprising coupling a carboxylic acid of Formula 2 (Rx-X OH Formula 2 with an aniline of Formula 3 Formula 3 in the presence of a coupling agent.