公开(公告)号：WO1997039029A2

公开(公告)日：1997-10-23

申请号：PCT/US1997006732

申请日：1997-04-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BRIDON, Dominique, P. ,  QIU, Xiaoxing

IPC: C07K14/02

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/082 ,  C12N2730/10122 ,  G01N33/5764

Abstract: The subject invention relates to a peptide sequence corresponding to amino acid residues (117 to 128) of hepatitis B surface antigen and uses thereof. In particular, the peptide is an antigenic epitope and may therefore be used, for example, as a diagnostic reagent or in the production of a vaccine. Furthermore, the present invention also relates to a C(K/R)TC motif present within the peptide as well as to other peptides containing this motif.

Abstract translation: 本发明涉及对应于乙型肝炎表面抗原的氨基酸残基（117至128）的肽序列及其用途。 特别地，肽是抗原表位，因此可以用作例如诊断试剂或用于制备疫苗。 此外，本发明还涉及肽内存在的C（K / R）TC基元以及含有该基序的其它肽。

公开(公告)号：WO1997036912A1

公开(公告)日：1997-10-09

申请号：PCT/US1997001952

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  YANG, Chengxi ,  PATEL, Hemantkumar, H. ,  KU, Yi-Kin ,  LIU, Jih-Hua

IPC: C07H17/08

CPC classification number: C07H17/08 ,  Y02P20/55

Abstract: A process of preparing a 6-O-methyl erythromycin A derivative using a 2'-protected, 9-etheroxime erythromycin A intermediate is provided. A preferred protecting group for the 2'-position is acetyl. 2'-protected, 9-etheroxime erythromycin A derivatives are also provided. Also disclosed is a method for inhibiting quaternary salt formation at the 3' amine without the need for 3'N-protecting groups.

Abstract translation: 提供了使用2'-保护的9-乙烯基肟红霉素A中间体制备6-O-甲基红霉素A衍生物的方法。 2位的优选保护基是乙酰基。 还提供了2'-保护的9-乙酰肟红霉素A衍生物。 还公开了抑制在3'胺上形成季盐的方法，而不需要3'N保护基团。

公开(公告)号：WO1997034924A1

公开(公告)日：1997-09-25

申请号：PCT/US1997001954

申请日：1997-02-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FUNK, Kenneth, W. ,  LUNDELL, Edwin, O. ,  MILLER, Robert, B. ,  CHANG, Jane, L. ,  KISHORE, Vimal ,  NAPIER, James, J. ,  STAEGER, Michael, A.

IPC: C07K07/23

CPC classification number: C07K7/23 ,  A61K38/00 ,  C07D307/14

Abstract: A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.

Abstract translation: 提供了通过溶液相肽化学制备LHRH的十肽和十一肽衍生物以及以相同方法有用的中间体肽的方法。

公开(公告)号：WO1997031364A1

公开(公告)日：1997-08-28

申请号：PCT/US1997002471

申请日：1997-02-18

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WANG, Jianjun ,  BOUSKA, Annette, G. ,  DRAYER, Lonnie, R.

IPC: G10K11/02

CPC classification number: G10K11/02 ,  A61B8/0866 ,  A61B8/4281 ,  A61B8/4405 ,  G01N29/28

Abstract: A pad (101) for transmitting acoustical waves between an ultrasound probe (107) and a target surface (105). The pad (101) includes a first layer (102) having a first porous portion which defines first layer pores therethrough. The first layer pores have a first layer pore dimension. The pad (101) further includes a second layer (103) having a first porous portion which defines second layer pores therethrough. The second layer pores have a second layer pore dimension. The second layer (103) is attached to the first layer (102) to define a space (104) therebetween. The first porous portion of the first layer (102) overlies the first porous portion of said second layer (103). An ultrasound couplant (100) is disposed in the space (104) defined between the first (102) and second (103) layers. The ultrasound couplant (100) has a molecule size that is less than or substantially equal to the first layer pore dimension and less than or substantially equal to the second layer pore dimension.

Abstract translation: 用于在超声波探头（107）和目标表面（105）之间传输声波的焊盘（101）。 垫（101）包括具有第一多孔部分的第一层（102），该第一多孔部分限定穿过其中的第一层孔。 第一层孔具有第一层孔尺寸。 垫（101）还包括具有第一多孔部分的第二层（103），该第一多孔部分限定穿过其中的第二层孔。 第二层孔具有第二层孔尺寸。 第二层（103）附接到第一层（102）以在其间限定空间（104）。 第一层（102）的第一多孔部分覆盖在所述第二层（103）的第一多孔部分上。 超声耦合剂（100）设置在限定在第一（102）和第二（103）层之间的空间（104）中。 超声耦合剂（100）具有小于或基本上等于第一层孔尺寸并小于或基本上等于第二层孔尺寸的分子尺寸。

公开(公告)号：WO1997030749A1

公开(公告)日：1997-08-28

申请号：PCT/US1997002264

申请日：1997-02-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ELSTROM, Tuan, A. ,  SHAIN, Eric, B. ,  HENNING, Timothy, P.

IPC: A61M37/00

CPC classification number: A61B5/14514 ,  A61M37/0092 ,  A61M2037/0007

Abstract: A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.

Abstract translation: 跨越动物皮肤取样细胞外液的过程包括在皮肤上建立超声驻波并收集流体渗出物。 可以通过将超声波与部分真空的应用组合到皮肤表面来增强采样。 一种装置包括超声换能器，反射器和用于收集渗出物的吸收材料。 该装置还可以包括用于降低皮肤表面上的静水压力的压力分量。

公开(公告)号：WO1997028447A1

公开(公告)日：1997-08-07

申请号：PCT/US1997001429

申请日：1997-01-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BIENIARZ, Christopher ,  HUFF, Jeffrey, B. ,  CORNWELL, Michael, J. ,  TATA VENKATA, Seshagiri, R.

IPC: G01N33/533

CPC classification number: C09B69/10 ,  G01N33/533 ,  Y10S436/80 ,  Y10T436/14 ,  Y10T436/141111 ,  Y10T436/17 ,  Y10T436/18

Abstract: Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformationally restrictive moiety either bound thereto or in close association therewith. The hydrophobic and conformationally restrictive moiety is preferably derived from a cyclodextrin. The polymeric dye comprises a polymeric entity having signal-generating groups, such as aminostyryl pyridinium dye residues attached thereto. The fluorescent conjugates exhibit exceptional stability characteristics and avoid many of the problems of energy transfer, bio-conjugability, and solubility.

Abstract translation: 适用于流式细胞术和其他生物应用的荧光偶联物。 荧光共轭物包含具有与其结合的聚合染料的抗体。 聚合染料优选通过与其结合或与其紧密结合的疏水性和构象限制性部分增强。 疏水和构象限制性部分优选衍生自环糊精。 聚合染料包括具有信号产生基团的聚合物，例如与其连接的氨基苯乙烯基吡啶鎓染料残基。 荧光共轭物表现出优异的稳定性特征，并避免了许多能量转移，生物共轭性和溶解度的问题。

公开(公告)号：WO1997027328A1

公开(公告)日：1997-07-31

申请号：PCT/US1997001179

申请日：1997-01-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GORDON, Julian

IPC: C12Q01/68

CPC classification number: C12Q1/6827 ,  C12Q1/6825 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2565/607 ,  C12Q2525/151

Abstract: Provided herein is a method for analyzing a target nucleic acid to determine the number of tandemly repeated sequences, which may form a part of the target sequence, relative to a complementary oligonucleotide. Also provided is a target sequence capture reagent for capturing a target sequence which comprises a tandemly repeated sequence.

Abstract translation: 本文提供了一种用于分析靶核酸以相对于互补寡核苷酸确定可能形成靶序列的一部分的串联重复序列的数目的方法。 还提供了用于捕获包含串联重复序列的靶序列的靶序列捕获试剂。

公开(公告)号：WO1997027305A1

公开(公告)日：1997-07-31

申请号：PCT/US1996001247

申请日：1996-01-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADAMS, Lee, F. ,  WIDNER, William, R. ,  DIDERICHSEN, Borge, K. ,  THOMAS, Michael, D. ,  JORGENSEN, Steen, T. ,  SLOMA, Alan, P. ,  JORGENSEN, Per, L.

IPC: C12N15/75

CPC classification number: C12N15/75

Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.

Abstract translation: 本发明涉及一种用于生产苏云金芽孢杆菌的整合体的方法。 本发明还涉及这样的整合剂，包含这种整合剂的组合物以及使用这些组合物来控制害虫的方法。

公开(公告)号：WO1997025878A1

公开(公告)日：1997-07-24

申请号：PCT/US1997001009

申请日：1997-01-21

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MULCHANDANI, Rohini, Prakash ,  MAHMOUD, Mohamed, Ibrahim

IPC: A23L01/0532

CPC classification number: A23L29/262 ,  A23L29/256 ,  Y10S426/80 ,  Y10S426/801 ,  Y10S426/804

Abstract: The present invention is a liquid nutritional product with improved physical stability comprising: (a) a liquid nutritional mixture containing fat at a concentration sufficient to have the liquid nutritional mixture be susceptible to creaming and containing suspended minerals present at a concentration sufficient to have the liquid nutritional mixture be susceptible to sedimentation; (b) a carrageenan/microcrystalline cellulose/carboxymethyl cellulose additive composition comprising: (i) iota-carrageenan present in an amount of about 100-800 ppm of the liquid nutritional product; (ii) a mixture of microcrystalline cellulose/carboxymethyl cellulose, the mixture present in an amount of from about 600-3000 ppm of the liquid nutritional product. In a preferred embodiment, microcrystalline cellulose is present in a range of from about 1000 ppm to about 2500 ppm, while the iota-carrageenan is present in a range of from about 100 ppm to about 300.

Abstract translation: 本发明是一种具有改善的物理稳定性的液体营养产品，其包括：（a）含有足以使液体营养混合物易于起霜并含有以足以具有液体的浓度存在的悬浮矿物质的脂肪的液体营养混合物 营养混合物易沉降; （b）角叉菜胶/微晶纤维素/羧甲基纤维素添加剂组合物，其包含：（i）以约100-800ppm的液体营养产品的量存在的ι-角叉菜聚糖; （ii）微晶纤维素/羧甲基纤维素的混合物，所述混合物的存在量为液体营养产品的约600-3000ppm。 在优选的实施方案中，微晶纤维素以约1000ppm至约2500ppm的范围存在，而ι-角叉菜胶存在的范围为约100ppm至约300。

公开(公告)号：WO1997024621A2

公开(公告)日：1997-07-10

申请号：PCT/US1996019544

申请日：1996-12-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ADAMCZYK, Maciej ,  FISHPAUGH, Jeffrey, R. ,  HEUSER, Kevin ,  RAMP, John, M. ,  WONG, Martin

IPC: G01N33/72

CPC classification number: C07D207/337 ,  C07D405/12 ,  G01N33/532 ,  G01N33/72 ,  G01N33/84

Abstract: Immunoassay methods and reagents for measuring the levels of lead in a test sample via the quantification of porphobilinogen use antibodies prepared with compounds of Formulas (II) and (III), wherein X and Y are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to an immunogenic carrier material P wherein P is preferably bovine serum albumin. Also described are the synthesis of fluorescein tracers of the structure of Formulas (V) and (VII), wherein A and C are linking groups consisting of 0 to 2 heteroatoms and 0 to 8 carbon atoms linked to a detectable moiety Q, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.

Abstract translation: 用于通过定量用式（II）和（III）化合物制备的胆色素原使用抗体来测定测试样品中铅含量的免疫测定方法和试剂，其中X和Y是由0至2个杂原子组成的连接基团和0至 8个碳原子与免疫原性载体材料P连接，其中P优选为牛血清白蛋白。 还描述了式（V）和（VII）结构的荧光素示踪剂的合成，其中A和C是连接到可检测部分Q的0至2个杂原子和0至8个碳原子组成的连接基团，其中Q 是可检测的部分，优选荧光素或荧光素衍生物。