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公开(公告)号：KR1020140098464A
公开(公告)日：2014-08-08
申请号：KR1020130011135
申请日：2013-01-31
Applicant: 강원대학교산학협력단
Abstract: The present invention relates to an enyne derivative represented by chemical formula 1 and a manufacturing method thereof and, more specifically, to a method for selectively manufacturing an enyne derivative with high yield by performing cross coupling reactions on halide derivatives and organic indium reagents produced in situ by making vinyl propargyl halide derivatives react with indium (In) under presence of palladium catalysts and to a novel enyne derivative manufactured by the method. (In chemical formula 1, R_1 and R_2 are the same as defined in the detailed prescription of the present invention.)
Abstract translation: 本发明涉及由化学式1表示的烯衍生物及其制备方法，更具体地说涉及通过对原位产生的卤化物衍生物和有机铟试剂进行交叉偶联反应来选择性地制备具有高收率的烯炔衍生物的方法 通过在钯催化剂的存在下使炔丙基卤衍生物与铟（In）反应，以及通过该方法制造的新型烯炔衍生物。 （在化学式1中，R 1和R 2与本发明的详细处方中定义相同）
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公开(公告)号：KR101356454B1
公开(公告)日：2014-02-04
申请号：KR1020130010345
申请日：2013-01-30
Applicant: 강원대학교산학협력단
IPC: C07C231/06 , C07C233/11 , C07B61/00
Abstract: The present invention relates to a method for preparing an unsaturated aldehyde compound, and to a method for preparing an unsaturated aldehyde compound, which, in the presence of a sulfonic acid compound and dichloroethane solvent, by including a step of reacting propargyl alcohol, a reaction step is very simple as compared with the prior art; has no by-product; and has high purity.
Abstract translation: 本发明涉及一种制备不饱和醛化合物的方法，以及制备不饱和醛化合物的方法，该方法在磺酸化合物和二氯乙烷溶剂存在下，通过包括使炔丙醇反应的步骤，反应 与现有技术相比，步骤非常简单; 没有副产品; 纯度高。
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43.发明授权신규한 하이드로퓨란 유도체와 이의 제조방법 및 이로부터 유도되는 신규한 하이드로아이소벤조퓨란 유도체와 이의 제조방법 有权新型氢氟烷衍生物及其制备方法及其应用于新型氢氯苯呋喃衍生物及其制备方法
公开(公告)号：KR101243612B1
公开(公告)日：2013-03-15
申请号：KR1020120069974
申请日：2012-06-28
Applicant: 강원대학교산학협력단
IPC: C07D307/78 , C07D307/28 , C07D491/048
Abstract: PURPOSE: A method for preparing a novel hydrofuran derivative is provided to simply obtain a hydrofuran derivative using a cheap copper catalyst. CONSTITUTION: A novel hydrofuran derivative contains a hydroisobenzo-furan derivative of chemical formula 1. In chemical formula 1, R^1 or R^2 is independently hydrogen, (C1-C6)alkyl group, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, (C3-C20)cycloalkyl, (C6-C20)aryl, or (C3-C20)heteroaryl.
Abstract translation: 目的：提供一种制备新型氢呋喃衍生物的方法，以简单地获得使用便宜的铜催化剂的氢呋喃衍生物。 化学式1中，R 1或R 2独立地是氢，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基，（C 1 -C 6）烷氧基， -C 6）烷氧基羰基，（C 3 -C 20）环烷基，（C 6 -C 20）芳基或（C 3 -C 20）杂芳基。
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公开(公告)号：KR101228381B1
公开(公告)日：2013-01-31
申请号：KR1020110031169
申请日：2011-04-05
Applicant: 강원대학교산학협력단
IPC: C07C45/61 , C07C49/537 , C07C69/753 , C07D307/80
Abstract: 본 발명은 철 촉매를 이용하여 α-알키닐 β-케토에스터 화합물의 분자내 고리화 반응을 통하여 온화한 조건하에서 보다 간단한 방법을 통해 높은 수율로 5각고리 화합물을 합성하는 제조방법을 제공한다.
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公开(公告)号：KR101221817B1
公开(公告)日：2013-01-16
申请号：KR1020120049439
申请日：2012-05-10
Applicant: 강원대학교산학협력단
IPC: C07D407/04 , C07D401/04 , A61K31/353 , B01J23/38
Abstract: PURPOSE: A bichromene or biquinoline derivative and a method for preparing the same are provided to synthesize derivatives of high purity with high yield. CONSTITUTION: A method for preparing a compound of chemical formula 1 comprises a step of cyclizing a compound of chemical formula 3 under the presence of a gold catalyst, a silver catalyst, or a mixture thereof. The gold catalyst includes AuCl, AuCl_, Ph_PAuCl, (C_6F_5)_3PAuCl, (4-CF_3-C_6H_4)_3PAuCl, IMesAuCl(IMes : 1,3-bis(2,4,6-trimethylphenyl)imidazol-2- ylidene), IPrAuCl(IPr : 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), or Au(JohnPhos)Cl(JohnPhos : (2-biphenyl)di-tert-butylphosphine). The silver catalyst is AgOTf, AgNTf_2, AgSbF_6, AgAsF_6, AgBF_4, or AgNO_3. The cyclization is performed in a solvent of dichloromethane(DCM), dichloroethane(DCE), toluene, acetonitrile, nitromethane, tetrahydrofurane(THF), N,N-dimethylformamide(DMF), or N,N-dimethyl acetamide(DMA).
Abstract translation: 目的：提供双色性或双喹啉衍生物及其制备方法以高产率合成高纯度衍生物。 构成：制备化学式1的化合物的方法包括在金催化剂，银催化剂或其混合物的存在下使化学式3的化合物环化的步骤。 金催化剂包括AuCl，AuCl_，Ph_PAuCl，（C_6F_5）_3PAuCl，（4-CF_3-C_6H_4）_3PAuCl，IMesAuCl（IMes：1,3-双（2,4,6-三甲基苯基）咪唑-2-亚基），IPrAuCl （IPr：1,3-双（2,6-二异丙基苯基）咪唑-2-亚基）或Au（JohnPhos）Cl（JohnPhos：（2-联苯基）二叔丁基膦）。 银催化剂是AgOTf，AgNTf_2，AgSbF_6，AgAsF_6，AgBF_4或AgNO_3。 环化在二氯甲烷（DCM），二氯乙烷（DCE），甲苯，乙腈，硝基甲烷，四氢呋喃（THF），N，N-二甲基甲酰胺（DMF）或N，N-二甲基乙酰胺（DMA）的溶剂中进行。
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Patent Agency Ranking
公开(公告)号：KR101210428B1
公开(公告)日：2012-12-10
申请号：KR1020100104367
申请日：2010-10-26
Applicant: 강원대학교산학협력단
Abstract: 본발명은하기화학식 1로표시되는엔올포스페이트유도체및 이의제조방법에관한것이다. 보다상세하게는, 서로다른금 촉매계를이용하여알카인유도체를포스페이트유도체와의첨가반응을통하여하기화학식 A로표시되는카이네틱(kinetic) 엔올포스페이트유도체와하기화학식 B로표시되는써모다이나믹(thermodynamic) 엔올포스페이트유도체를각각선택적으로제조하는방법에관한것이다. [화학식 1][화학식 A][화학식 B]상기화학식 1, 화학식 A 및화학식 B에서 R, R, R및 R는각각발명의상세한설명에서정의한바와같다.
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公开(公告)号：KR1020110077205A
公开(公告)日：2011-07-07
申请号：KR1020090133701
申请日：2009-12-30
Applicant: 강원대학교산학협력단
IPC: C07D307/58
Abstract: PURPOSE: A 3-arylbutenolide derivative and a method for preparing the same are provided to develop a novel drug and various medicines. CONSTITUTION: A 3-arylbutenolide derivative is denoted by chemical formula 1. A method for preparing the 3-arylbutenolide derivative comprises a step of performing intramolecular cyclization of 2-aryl allenoate derivative of chemical formula 2 under the presence of gold(Au) catalyst and acid. The gold catalyst is monovalent AuBr, AuCl, or PPh_3AuCl, or trivalent AuBr_3 or AuCl_3. The acid is CF_3CO_2H, CH_3CO_2H, CF_3SO_3H.
Abstract translation: 目的：提供3-芳基丁烯醇内酯衍生物及其制备方法，以开发新型药物和各种药物。 构成：3-芳基丁烯酸酯衍生物由化学式1表示。制备3-芳基丁烯醇内酯衍生物的方法包括在金（Au）催化剂存在下进行化学式2的2-芳基丙烯酸酯衍生物的分子内环化的步骤， 酸。 金催化剂是一价AuBr，AuCl或PPh_3AuCl，或三价AuBr_3或AuCl_3。 酸是CF_3CO_2H，CH_3CO_2H，CF_3SO_3H。
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公开(公告)号：KR1020110075880A
公开(公告)日：2011-07-06
申请号：KR1020090132449
申请日：2009-12-29
Applicant: 강원대학교산학협력단
IPC: C07C69/612 , C07C69/54 , C07C67/333
Abstract: PURPOSE: A method for preparing 2-aryl allenoate derivatives is provided to obtain 2-aryl allenoate derivatives with high yield through a cross coupling reaction of an organic indium reagent in the presence of an arene derivative and palladium catalyst, wherein the organic indium reagent is obtained in in-situ from the reaction of indium with 4-bromo-2-butenoate. CONSTITUTION: A method for preparing 2-aryl allenoate derivatives is represented by chemical formula 1. In chemical formula 1, R^1 and R^5 are hydrogen, (C1~C7) alkyl, halogen, (C6~C20) aryl or (C1~C7) alkoxycarbonyl; R^2 and R^4 are hydrogen, (C1~C7) alkoxy or nitro; R^3 is hydrogen, (C1~C7) alkyl, (C6~C20) aryl, halogen, formyl, acetyl, alkoxycarbonyl or (C6~C20) aryl (C1~C7) alkylcarbamoyl aryl; R^6 is hydrogen or (C1~C7) alkyl; and R^7 is (C1~C7) alkyl or (C6~C20) aryl.
Abstract translation: 目的：提供2-芳基烯酸酯衍生物的制备方法，通过有机铟试剂在芳族衍生物和钯催化剂的存在下的交叉偶联反应，以高产率得到2-芳基全烯酸酯衍生物，其中有机铟试剂为 由铟与4-溴-2-丁烯酸酯的反应原位获得。 化学式1中R 1和R 5为氢，（C 1 -C 7）烷基，卤素，（C 6〜C 20）芳基或（C 6〜C 20）芳基或 C1〜C7）烷氧基羰基; R 2和R 4是氢，（C 1 -C 7）烷氧基或硝基; 卤素，甲酰基，乙酰基，烷氧基羰基或（C6〜C20）芳基（C1〜C7）烷基氨基甲酰基芳基;（C1〜C7）烷基，（C1〜C7） R 6是氢或（C 1 -C 7）烷基; R 7为（C 1 -C 7）烷基或（C 6〜C 20）芳基。
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公开(公告)号：KR101014885B1
公开(公告)日：2011-02-15
申请号：KR1020080066689
申请日：2008-07-09
Applicant: 강원대학교산학협력단
IPC: C07C2/64 , C07C15/44 , C07D213/00
CPC classification number: Y02P20/52
Abstract: 본 발명은 알릴 유도체와 인듐으로부터 제조되는 알릴 인듐 화합물과 아릴 브로마이드 또는 트리플루오로메탄술포네이트와의 교차-짝지음 반응을 통해서 효과적으로 하기 화학식 1로 표시되는 알릴벤젠 유도체를 제조하는 방법에 관한 것이다.
상기 화학식 1에서, A는 CR
4 또는 N을 나타내며; R
1 , R
2 , R
3 , R
4 또는 R
5 는 서로 독립적으로 수소, C
1 -C
5 의 알킬, C
1 -C
5 의 알콕시, C
1 -C
5 의 알킬카르보닐, C
1 -C
5 의 알콕시카르보닐, C
1 -C
5 의 아마이드, 벤질 아마이드 또는 니트릴을 나타내거나, R
1 과 R
2 또는 R
2 와 R
3 가 서로 연결되어 벤젠고리를 형성할 수 있으며; R
6 , R
7 또는 R
8 은 서로 독립적으로 수소, C
1 -C
5 의 알킬기 또는 C
1 -C
5 의 알콕시기를 나타낸다.
알릴 치환체, 알릴인듐, 교차-짝지움 반응, 인듐-
公开(公告)号：KR1020090088177A
公开(公告)日：2009-08-19
申请号：KR1020080013570
申请日：2008-02-14
Applicant: 강원대학교산학협력단
Abstract: A method for manufacturing an aromatic multicyclic compound is provided to synthesize the aromatic multicyclic compound with excellent yield by intersection-pairing reaction with various electrophilic aromatic compounds by in-situ reaction. An aromatic multicyclic compound has a naphthyl group represented by chemical formula 1. In chemical formula 1, A is an aromatic multicyclic group selected from 1,1'-biphenyl, 4- iodo-1,1'-biphenyl, 4-bromo-1,1'-biphenyl, 9,10-anthracenyl, fluorenyl, 9,9'-dimethylfluorenyl, carbazolyl, 9-ethylcarbazolyl, 2,2'-bithiophenyl, 9,9'-spirobifluorenyl and 1-pyrenyl.
Abstract translation: 提供了一种制备芳族多环化合物的方法，通过原位反应与各种亲电子芳香族化合物进行交叉配对反应合成具有优异收率的芳族多环化合物。 芳族多环化合物具有由化学式1表示的萘基。在化学式1中，A是选自1,1'-联苯，4-碘-1,1'-联苯，4-溴-1 芴基，9,9'-二甲基芴基，咔唑基，9-乙基咔唑基，2,2'-二噻吩基，9,9'-螺二芴基和1-芘基。
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