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公开(公告)号：KR1020120010426A
公开(公告)日：2012-02-03
申请号：KR1020100071955
申请日：2010-07-26
Applicant: 한국과학기술연구원
Abstract: PURPOSE: A pharmaceutical composition containing Opuntia ficus-indica extract for preventing and treating memory loss is provided to strengthen ERK-CREB-BDNF signal in hippocampus. CONSTITUTION: A pharmaceutical composition for preventing and treating amnesia or memory loss-associated diseases contains Opuntia ficus-indica extract as an active ingredient. The extract is Opuntia ficus-indica stem extract. The extract is prepared using water, low alcohol of C1-C6, or mixture thereof. A health food for treating amnesia or memory loss contains the extract as an active ingredient. The health food is power, granules, tablet, capsule, or beverage.
Abstract translation: 目的：提供含有用于预防和治疗记忆丧失的仙人掌榕提取物的药物组合物，以加强海马中的ERK-CREB-BDNF信号。 构成：用于预防和治疗遗忘症或记忆丧失相关疾病的药物组合物含有榕contains提取物作为活性成分。 提取物是仙人掌榕茎提取物。 提取物是使用水，C1-C6低级醇或其混合物制备的。 用于治疗遗忘或记忆丧失的保健食品含有提取物作为活性成分。 保健食品是动力，颗粒，片剂，胶囊或饮料。
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42.发明公开
公开(公告)号：KR1020100084038A
公开(公告)日：2010-07-23
申请号：KR1020090003430
申请日：2009-01-15
Applicant: 한국과학기술연구원
IPC: A61K36/185 , A61K31/12 , A61P1/16
CPC classification number: A61K31/7032 , A61K36/185 , Y10S514/893
Abstract: PURPOSE: A composition containing Alnus hirsute stem extract or a compound isolated from the same is provided to protect hepatocytes and to prevent and treat liver diseases. CONSTITUTION: A composition for preventing and treating hepatotoxicity contains Alnus hirsute stem extract as an active ingredient. A composition for preventing and treating hepatotoxicity contains a compound of chemical formula 1 as an active ingredient. A method for preparing the Alnus hirsute extract comprises: a step of adding 0.1-10L of alcohol per 1kg of cut Alnus hirsute stem and refluxing at 60-100 °C for 2 to 6 hours; a step of filtering and decompressing extract; and a step of extracting with 1-5L of ethylacetate to obtain fraction.
Abstract translation: 目的：提供含有Alnus多毛茎提取物或从其分离的化合物的组合物以保护肝细胞并预防和治疗肝脏疾病。 构成：用于预防和治疗肝毒性的组合物含有阿尔金斯多毛提取物作为活性成分。 用于预防和治疗肝毒性的组合物含有化学式1的化合物作为活性成分。 一种制备Al ute提取物的方法，其特征在于，每1kg切割的Al藜茎加入0.1-10L的酒精并在60-100℃下回流2至6小时; 过滤和解压缩提取步骤; 和用1-5L乙酸乙酯萃取以获得级分的步骤。
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公开(公告)号：KR100543897B1
公开(公告)日：2006-01-23
申请号：KR1020030036482
申请日：2003-06-05
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: 본 발명은 활성산소 소거활성 및 항바이러스활성을 가지는 치자 추출물, 그로부터 분리된 신규한 화합물 및 그 용도에 관한 것이다. 보다 상세하게는 물 또는 유기용매로 추출되며, 유효성분으로 메틸 5-
O -카페오일-4-
O -시나포일퀴네이트, 메틸 3,5-
O -디카페오일-4-
O -(3-히드록시-3-메틸)글루타로일퀴네이트, 에틸 5-
O -카페오일-4-
O -시나포일퀴네이트, 메틸 3-
O -카페오일-5-
O -시나포일퀴네이트, 에틸 3-
O -카페오일-5-
O -시나포일퀴네이트, 3,5-
O - 디카페오일퀴닉산 및 4,5-
O -디카페오일퀴닉산을 포함하는 활성산소소거활성 및 항바이러스활성을 나타내는 치자추출물. 그로부터 분리된 신규 화합물에 관한 것이다.
본 발명에 의한 치자 추출물 및 분리된 신규화합물들은 DPPH 자유라디칼, 슈퍼옥사이드 음이온 라디칼 등의 활성산소 소거활성이 우수하여 활성 산소에 의한 질병을 치료 및 예방하는데 뛰어난 효과가 있으며, 인간면역결핍바이러스의 인티그라제에 대한 저해 활성 및 항바이러스활성도 높아 AIDS 등 바이러스성 질환의 치료에 응용될 수 있다.
치자, 활성산소 소거활성, 인티그라제(integrase), 항바이러스활성, AIDS,-
44.发明授权
公开(公告)号：KR100523562B1
公开(公告)日：2005-10-25
申请号：KR1020020065744
申请日：2002-10-28
Applicant: 한국과학기술연구원
CPC classification number: A61K31/352 , A61K36/33
Abstract: 본 발명은 손바닥선인장을 에틸 아세테이트로 추출하여 얻은 신경세포 보호효과를 갖는 추출물 및, 이 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 신경세포 보호용 약학 조성물에 관한 것으로, 본 발명의 약학 조성물은 알쯔하이머병, 뇌졸중, 파킨슨병과 같은 뇌신경질환에 의한 뇌신경세포 손상, 허혈로 인한 세포와 조직 손상 또는 심근경색과 같은 심혈관계 질환의 예방 및 치료에 유용하게 사용될 수 있다.
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公开(公告)号：KR100408928B1
公开(公告)日：2003-12-11
申请号：KR1020010018228
申请日：2001-04-06
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: PURPOSE: A composition for the prevention and treatment of ischemic disease containing aloesin as an effective ingredient and a preparation containing the same is provided. Because aloesin as an aloe component has an excellent neuroprotective effect and nerve-ethological recovering effect, the composition containing the same can be effectively used in treatment of nerve cell and tissue damage caused by cerebral ischemia. CONSTITUTION: The composition for prevention and treatment of ischemia disease contains aloesin of the formula 1 £8-C-β -D-glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one|, a pharmaceutically acceptable salt, hydrate or solvate or isomer and a pharmaceutically acceptable carrier thereof. The composition is formulated into a tablet, hard and soft gelatin capsule, liquid, suspension, injection, ointment, cream, gel or lotion. The composition is a neuroprotective composition for the prevention and treatment of ischemic apoplexy or concussion and a heart protecting composition for the prevention and treatment of ischemic myocardial infarction.
Abstract translation: 目的：提供一种含有芦荟苷作为有效成分的缺血性疾病的预防和治疗用组合物及含有该组合物的制剂。 由于芦荟芦荟成分具有优良的神经保护作用和神经行为恢复作用，因此含有该成分的组合物可以有效地用于治疗由脑缺血引起的神经细胞和组织损伤。 构成：用于预防和治疗局部缺血疾病的组合物含有式1＆8; 8-C＆amp;β的芦荟黄素; D-吡喃葡萄糖基-7-羟基-5-甲基-2-（2-氧代丙基）-4H-1-苯并吡喃-4-酮，其药学上可接受的盐，水合物或溶剂合物或异构体及其药学上可接受的载体。 该组合物被配制成片剂，硬和软明胶胶囊，液体，悬浮液，注射剂，软膏，乳膏，凝胶或洗剂。 该组合物是用于预防和治疗缺血性中风或脑震荡的神经保护组合物，以及用于预防和治疗缺血性心肌梗塞的心脏保护组合物。
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Patent Agency Ranking46.发明公开
公开(公告)号：KR1020020078202A
公开(公告)日：2002-10-18
申请号：KR1020010018228
申请日：2001-04-06
Applicant: 한국과학기술연구원
IPC: A61K31/70
Abstract: PURPOSE: A composition for the prevention and treatment of ischemic disease containing aloesin as an effective ingredient and a preparation containing the same is provided. Because aloesin as an aloe component has an excellent neuroprotective effect and nerve-ethological recovering effect, the composition containing the same can be effectively used in treatment of nerve cell and tissue damage caused by cerebral ischemia. CONSTITUTION: The composition for prevention and treatment of ischemia disease contains aloesin of the formula 1 £8-C-β -D-glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one|, a pharmaceutically acceptable salt, hydrate or solvate or isomer and a pharmaceutically acceptable carrier thereof. The composition is formulated into a tablet, hard and soft gelatin capsule, liquid, suspension, injection, ointment, cream, gel or lotion. The composition is a neuroprotective composition for the prevention and treatment of ischemic apoplexy or concussion and a heart protecting composition for the prevention and treatment of ischemic myocardial infarction.
Abstract translation: 目的：提供一种预防和治疗含有芦荟素作为有效成分的缺血性疾病的组合物和含有它们的制剂。 因为作为芦荟成分的芦荟素具有优异的神经保护作用和神经病理恢复效果，所以含有该芦荟成分的组合物可有效地用于治疗由脑缺血引起的神经细胞和组织损伤。 构成：用于预防和治疗缺血性疾病的组合物含有式1的8-C-β-D-吡喃葡萄糖基-7-羟基-5-甲基-2-（2-氧代丙基）-4H-1-苯并吡喃-2-酮的芦荟碱， 4-酮|，其药学上可接受的盐，水合物或溶剂合物或其异构体及其药学上可接受的载体。 将组合物配制成片剂，硬和软明胶胶囊，液体，悬浮液，注射剂，软膏，霜剂，凝胶或洗剂。 该组合物是用于预防和治疗缺血性中风或脑震荡的神经保护组合物和用于预防和治疗缺血性心肌梗死的心脏保护组合物。
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公开(公告)号：KR1020020008944A
公开(公告)日：2002-02-01
申请号：KR1020000041969
申请日：2000-07-21
Applicant: 한국과학기술연구원
IPC: A61K36/855 , A61P31/18 , A61P37/00
Abstract: PURPOSE: An anti-HIV agent containing an alcohol extract of Clerodendron trichotomum and a purified compound separated therefrom an as effective component, in particular an inhibitor for HIV integrase is provided, which has no drug resistance or side effects as defects of a reverse transciptase inhibitor and a protease inhibitor. CONSTITUTION: An alcohol extract of Clerodendron trichotomum having a formula 1 has an anti-HIV activity, in particular an inhibiting activity against HIV integrase. In formula, R1 is H or methyl, R2 is H, caffeoyl, or feruloyl, R3 is H, caffeoyl or feruloyl. For an example, 4.8kg Clerodendron trichotomum is extracted in methanol at room temperature and fractionated into dichloromethane and water. The fraction is subjected to column chromatography with sephadex LH-20 and then silica gel column chromatography to produce 880.8mg compound of the formula 1.
Abstract translation: 目的：提供含有Clerodendron trichotomum的醇提取物和从其分离的纯化化合物作为有效成分，特别是HIV整合酶抑制剂的抗HIV剂，其不具有作为逆转录酶抑制剂缺陷的耐药性或副作用 和蛋白酶抑制剂。 构成：具有式1的Clerodendron trichotomum的醇提取物具有抗HIV活性，特别是抗HIV整合酶的抑制活性。 在式中，R 1是H或甲基，R 2是H，咖啡酰基或阿魏酰基，R 3是H，咖啡酰基或阿魏酰基。 例如，4.8kg Clerodendron trichotomum在室温下在甲醇中萃取并分馏成二氯甲烷和水。 将级分用sephadex LH-20进行柱层析，然后用硅胶柱色谱法进行柱色谱，得到880.8mg式1的化合物。
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公开(公告)号：KR102233117B1
公开(公告)日：2021-03-29
申请号：KR1020190128516
申请日：2019-10-16
Applicant: 한국과학기술연구원
IPC: A61K36/28 , A61P17/14 , A61K8/9789 , A61Q7/00 , A23L33/105
Abstract: 본발명은까실쑥부쟁이알콜추출물과이로부터분획한용매분획물을유효성분으로함유하는발모(육모)촉진또는탈모방지용조성물에관한것으로서, 본발명의조성물은우수한모발기생장유도효과, 퇴행기탈모방지효과및 피부세포증식효과를보유하는바, 종래기술에따른발모촉진제또는탈모방지제에서야기되던다양한문제점들을효과적으로보완할수 있는, 우수한발모촉진및 탈모방지용조성물에관한것이다.
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公开(公告)号：KR102197684B1
公开(公告)日：2021-01-04
申请号：KR1020200132003
申请日：2020-10-13
Applicant: 고려대학교 산학협력단 , 한국과학기술연구원
IPC: A61K31/192 , A61K36/28 , A61K9/00 , A61Q19/00 , A23L33/10 , A61P17/00 , A61P29/00 , A61K8/368 , A61K8/9789
Abstract: 본발명은피부장벽강화및 피부장벽손상예방용조성물에관한것으로, 섬쑥부쟁이(Aster glehni) 추출물로부터분리된 3,5-디카페올리퀴닉산(3,5-dicaffeoylquinic acid)을화장료조성물및 약제학적조성물의유효성분으로도입함으로써, 피부장벽손상을개선하고, 피부염증을완화하여아토피피부염에대한예방및 개선효과가있다.
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