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公开(公告)号：KR100497258B1
公开(公告)日：2005-06-28
申请号：KR1020030003320
申请日：2003-01-17
IPC: A61K9/107
Abstract: 본 발명은 동맥색전술에 이용가능한 에멀젼으로 조성가능한 파클리탁셀 혼합 조성물, 그의 유중수형 (water-in-oil (w/o)) 에멀젼 조성물 및 그 제조방법에 관한 것이다. 본 발명의 에멀젼 제형은 수용성 및 지용성 약제를 추가로 포함할 수 있으므로 항암제 복합제등 복합제형을 용이하게 제조할 수 있다.
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公开(公告)号：KR100426636B1
公开(公告)日：2004-04-08
申请号：KR1020010027171
申请日：2001-05-18
Applicant: 한국과학기술연구원
IPC: A61K9/00
Abstract: PURPOSE: A process of preparing a gel type composition containing a specified amount of a biocompatible polymer is provided. Whereby, the composition can be used as a local drug delivery system and formulations thereof and release drug from a local portion for 6 days. CONSTITUTION: This gel type composition comprises a phospholipid-based compound, drug and water, wherein the composition additionally contains 3% by weight of one or more biocompatible polymers selected from the group consisting of hyaluronic acid, chitosan and alginic acid. The phospholipid-based compound is one or more selected from a saturated or unsaturated C6-22 phosphatidylcholine-based compound, phosphatidylethanolamine-based compound, phosphatidylserine-based compound and phosphatidic acid-based compound.
Abstract translation: 目的：提供一种制备含有特定量的生物相容性聚合物的凝胶型组合物的方法。 由此，该组合物可以用作局部药物递送系统及其制剂并且将药物从局部释放6天。 构成：该凝胶型组合物包含基于磷脂的化合物，药物和水，其中所述组合物另外含有3重量％的一种或多种选自透明质酸，壳聚糖和海藻酸的生物相容性聚合物。 磷脂类化合物为选自饱和或不饱和C6-22磷脂酰胆碱类化合物，磷脂酰乙醇胺类化合物，磷脂酰丝氨酸类化合物和磷脂酸类化合物中的一种或多种。
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43.发明公开
公开(公告)号：KR1020040020679A
公开(公告)日：2004-03-09
申请号：KR1020020052346
申请日：2002-08-31
Applicant: 한국과학기술연구원
IPC: A61K47/44
CPC classification number: A61K9/107 , A61K9/0019 , A61K47/30 , A61K47/44 , A61K48/0033 , A61K49/0438
Abstract: PURPOSE: A new oil-in-water type emulsion formulation using an oil phase contrast agent and a cationic polymer allowing effective delivery of a physiologically active substance such as a gene or a drug into cells is provided together with a method for production thereof. The gene or drug delivery formulation for topical application exhibits high transfection efficiency in desired targeted cells for a long period of time in the case of local gene delivery. CONSTITUTION: The complex formulation for effective delivery of a physiologically active substance such as a gene or a drug into targeted cells comprises 10 to 50% by weight of a cationic polymer and 50 to 90% by weight of iodized oils. The binding ratio of the physiologically active substance and cationic polymer is 1:1 to 1:2. The cationic polymer is selected from the group consisting of polylysine, dendrimer, linear polyethyleneimine, branched polyethyleneimine, chitosan, diethylaminoethyl-dextran, polydimethyl and aminoethylmethacrylate and the iodized oils are selected from the group consisting of iodized poppy seed oil, ethiodol and iodized soybean oil.
Abstract translation: 目的：提供一种使用油相造影剂和允许将生理活性物质如基因或药物有效递送到细胞中的阳离子聚合物的新的水包油型乳液制剂及其生产方法。 用于局部应用的基因或药物递送制剂在局部基因递送的情况下在期望的靶细胞中长时间显示高转染效率。 构成：将有效递送诸如基因或药物的生理活性物质的复合制剂包含10至50重量％的阳离子聚合物和50至90重量％的碘化油。 生理活性物质和阳离子聚合物的结合比为1:1至1:2。 阳离子聚合物选自聚赖氨酸，树枝状聚合物，线性聚乙烯亚胺，支化聚乙烯亚胺，壳聚糖，二乙基氨基乙基 - 葡聚糖，聚二甲基和氨乙基甲基丙烯酸酯，碘化油选自碘化罂粟籽油，乙醇碘化物和碘化大豆油 。
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公开(公告)号：KR1020040009018A
公开(公告)日：2004-01-31
申请号：KR1020020042794
申请日：2002-07-20
Applicant: 한국과학기술연구원
IPC: A61K31/245
CPC classification number: A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
Abstract: PURPOSE: Provided is a p-glycoprotein inhibitor which comprises otilonium bromide as an effective ingredient, thereby increasing the absorption of otilonium bromide into the cell and bioavailability of the drug in the living body. CONSTITUTION: A p-glycoprotein inhibitor is characterized by comprising, as an effective ingredient, otilonium bromide that inhibits the activity of p-glycoprotein and increases the absorption of drugs into the cell. The composition is formulated into a sustained release preparation and releases drugs continuously for 12 hours.
Abstract translation: 目的：提供一种P-糖蛋白抑制剂，其包含溴化溴铵作为有效成分，从而增加溴化铵对细胞的吸收和生物体内药物的生物利用度。 构成：P-糖蛋白抑制剂的特征在于包含抑制β-糖蛋白活性的otilonium溴化物作为有效成分，并增加药物对细胞的吸收。 将组合物配制成持续释放制剂并连续释放药物12小时。
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公开(公告)号：KR1020030023369A
公开(公告)日：2003-03-19
申请号：KR1020010056536
申请日：2001-09-13
IPC: A61K31/335
CPC classification number: A61K49/0452 , A61K9/0019 , A61K31/337 , A61K47/44
Abstract: PURPOSE: A process of preparing a paclitaxel oily composition for chemoembolization by adding paclitaxel to an oily contrast medium and then agitating is provided. The composition is easy to manufacture and sterilize and more physiochemically stable than conventional adriamycin/lipiodol preparation. CONSTITUTION: The paclitaxel oily composition is prepared by mixing 0.0001 to 10mg paclitaxel with 1ml oily contrast medium under sterilization conditions, agitating at room temperature and then sterilized by gamma ray. The oily contrast medium is iodized oil having an iodine content of 30 to 50% selected from iodized poppy seed oil, ethiodol and iodized soybean oil. The composition optionally contains 0.1 to 1ml animal oil such as squalane, vegetable oil such as soybean oil or a mixture thereof, based on 1ml oily contrast medium.
Abstract translation: 目的：提供通过将紫杉醇加入到油性造影剂中然后搅拌来制备用于化学栓塞的紫杉醇油性组合物的方法。 该组合物易于制造和消毒，并且比常规阿霉素/碘油制剂更具生理化学稳定性。 构成：通过在灭菌条件下将0.0001至10mg紫杉醇与1ml油性造影剂混合制备紫杉醇油性组合物，在室温下搅拌，然后用γ射线灭菌。 油性造影剂是选自碘化罂粟籽油，乙醇碘化物和碘化大豆油中碘含量为30〜50％的碘化油。 基于1ml油性造影剂，组合物任选地含有0.1至1ml动物油如角鲨烷，植物油如大豆油或其混合物。
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Patent Agency Ranking
公开(公告)号：KR1020020088181A
公开(公告)日：2002-11-27
申请号：KR1020010027171
申请日：2001-05-18
Applicant: 한국과학기술연구원
IPC: A61K9/00
CPC classification number: A61K9/06 , A61K9/0019 , A61K31/196 , A61K31/65 , A61K47/24 , A61K47/36
Abstract: PURPOSE: A process of preparing a gel type composition containing a specified amount of a biocompatible polymer is provided. Whereby, the composition can be used as a local drug delivery system and formulations thereof and release drug from a local portion for 6 days. CONSTITUTION: This gel type composition comprises a phospholipid-based compound, drug and water, wherein the composition additionally contains 3% by weight of one or more biocompatible polymers selected from the group consisting of hyaluronic acid, chitosan and alginic acid. The phospholipid-based compound is one or more selected from a saturated or unsaturated C6-22 phosphatidylcholine-based compound, phosphatidylethanolamine-based compound, phosphatidylserine-based compound and phosphatidic acid-based compound.
Abstract translation: 目的：提供一种制备含有特定量的生物相容性聚合物的凝胶型组合物的方法。 因此，组合物可以用作局部药物递送系统及其制剂，并从局部部分释放药物6天。 构成：该凝胶型组合物包含基于磷脂的化合物，药物和水，其中该组合物另外含有3重量％的一种或多种选自透明质酸，壳聚糖和海藻酸的生物相容性聚合物。 基于磷脂的化合物是选自饱和或不饱和的C6-22磷脂酰胆碱化合物，基于磷脂酰乙醇胺的化合物，磷脂酰丝氨酸基化合物和磷脂酸类化合物中的一种或多种。
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公开(公告)号：KR1020020066776A
公开(公告)日：2002-08-21
申请号：KR1020010007123
申请日：2001-02-13
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/0095 , A61K9/1075 , A61K9/4858
Abstract: PURPOSE: A process of preparing a peroral administration form for insulin is provided by using monoglycerides, emulsifiers, organic solvents, insulin and an acidic aqueous solution. Therefore, the formulation is excellent in a filling rate of insulin into the administration form and bioavailability as compared to prior art and has improved convenience. CONSTITUTION: A liquid peroral administration form for insulin comprises 0.01 to 20% by weight of insulin, 9 to 90% by weight of one or more monoglycerides, 0.01 to 90% by weight of one or more emulsifiers, 0.01 to 10% by weight of an acidic aqueous solution, 1 to 90% by weight of an organic solvent and 0 to 5% by weight of an additive, and is prepared by dissolving the emulsifier in the organic solvent, adjusting the solution to acidity, adding and agitating insulin powder, adding one or more monoglycerides and removing a volatile organic solvent from the obtained viscose composition.
Abstract translation: 目的：通过使用单酸甘油酯，乳化剂，有机溶剂，胰岛素和酸性水溶液来提供制备胰岛素口服给药形式的方法。 因此，与现有技术相比，该配方在胰岛素与给药形式的填充率和生物利用度方面是优异的，并且具有改进的便利性。 构成：用于胰岛素的液体口服给药形式包含0.01至20重量％的胰岛素，9至90重量％的一种或多种甘油单酯，0.01至90重量％的一种或多种乳化剂，0.01至10重量％ 酸性水溶液，1〜90重量％的有机溶剂和0〜5重量％的添加剂，通过将乳化剂溶解在有机溶剂中，将溶液调节至酸性，加入并搅拌胰岛素粉末， 加入一种或多种单甘油酯并从所得粘胶组合物中除去挥发性有机溶剂。
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公开(公告)号：KR1020010063154A
公开(公告)日：2001-07-09
申请号：KR1019990060034
申请日：1999-12-21
Applicant: 한국과학기술연구원
IPC: C12N1/00
CPC classification number: C08J9/28 , C08B37/003 , C08J2201/0484 , C08J2305/08 , C08L5/08 , C12N5/0075 , C12N2533/72
Abstract: PURPOSE: Provided are multi-porous chitosan bead whose pores are big and relatively constant in size and a preparation method thereof. The bead is used as a matrix for cell cultivation and for the study of alternative metabolic organ, bone and cartilage and protein, antibiotics, anti-cancer medicine, polysaccharide, biological active material, animal hormone, and plant hormone. CONSTITUTION: A multi-porous chitosan bead has a pore being 5-20 micrometer in a size at its inside and outside. It is prepared by the following steps of: (a) preparing chitosan solution by dissolving chitosan in acetic acid aqueous solution, water-soluble chitosan solution by dissolving water-soluble chitosan in deionized solution or mixed solution thereof; (b) making it in bead form by adding organic solvent of low temperature or liquid nitrogen; and (c) freeze-drying the resultant bead.
Abstract translation: 目的：提供孔径大且尺寸相对恒定的多孔壳聚糖珠及其制备方法。 该珠被用作细胞培养的基质和用于替代代谢器官，骨和软骨和蛋白质，抗生素，抗癌药物，多糖，生物活性物质，动物激素和植物激素的研究。 构成：多孔壳聚糖珠的内部和外部具有5-20微米的孔径。 通过以下步骤制备：（a）通过将水溶性壳聚糖溶解在去离子溶液或其混合溶液中，通过将壳聚糖溶解在乙酸水溶液，水溶性壳聚糖溶液中制备壳聚糖溶液; （b）通过加入低温或液氮的有机溶剂使其呈珠粒形式; 和（c）冷冻干燥所得的珠粒。
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公开(公告)号：KR1020000069800A
公开(公告)日：2000-11-25
申请号：KR1019997005944
申请日：1997-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/19
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: PURPOSE: A method of preparing a porous matrix-type drug delivery system by dispersing a drug-containing aqueous solution in an organic solvent in which a polymer compound and a surfactant are dissolved and forming the obtained emulsion into a desirable matrix shape is provided which can produce the titled system capable of being widely used for a therapeutic agent CONSTITUTION: The method for producing a porous matrix-type drug delivery system comprises the steps of: dispersing, stirring, and emulsifying an aqueous solution of a drug in an organic solvent having a polymer compound and a surface active agent solved therein; thereafter forming it into a desirable matrix shape; lyophilizing or drying it at a low temperature or room temperature until the matrix surface is hardened; and drying it again in order to remove the water and the organic solvent.
Abstract translation: 目的：提供一种通过将含药水溶液分散在其中溶解高分子化合物和表面活性剂的有机溶剂中并将所得乳液形成为期望的基质形状来制备多孔基质型药物递送系统的方法，其可以 制备能够广泛用于治疗剂的标题系统构成：多孔基质型药物递送系统的制备方法包括以下步骤：将药物的水溶液分散，搅拌和乳化在具有 高分子化合物和其中溶解的表面活性剂; 然后将其形成为期望的矩阵形状; 在低温或室温下冻干或干燥，直到基质表面硬化; 并再次干燥以除去水和有机溶剂。
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公开(公告)号：KR100181252B1
公开(公告)日：1999-03-20
申请号：KR1019960082443
申请日：1996-12-31
Applicant: 한국과학기술연구원
IPC: A61K9/10
CPC classification number: A61K9/7007 , Y10S514/953 , Y10S514/964 , Y10S514/975
Abstract: 약물이 포함된 수용액을 고분자화합물과 계면활성제가 유기용매에 용해된 유기용액에 분산 교반시켜 에멀젼으로 만든 다음, 원하는 매트릭스 형태로 만들어 즉시 동결건조하거나 상온에서 일정시간 즉 매트릭스 표면이 경화되기 시작할 때까지 건조시킨 후 다시 진공건조하여 다공성 매트릭스를 제조하는 것을 특징으로 함.
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