公开(公告)号：PL191453B1

公开(公告)日：2006-05-31

申请号：PL34029098

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

公开(公告)号：DE69830739T2

公开(公告)日：2006-04-20

申请号：DE69830739

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN TAM ,  OR SUN ,  CHU T ,  PLATTNER J ,  CHEN YAN ,  CLARK F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：DK1027362T3

公开(公告)日：2005-10-31

申请号：DK98956338

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  PHAN LY TAM ,  PLATTNER JACOB J ,  CLARK RICHARD F ,  CHEN YAN

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：DE69830739D1

公开(公告)日：2005-08-04

申请号：DE69830739

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN TAM ,  OR SUN ,  CHU T ,  PLATTNER J ,  CHEN YAN ,  CLARK F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：AT298760T

公开(公告)日：2005-07-15

申请号：AT98956338

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：DE60005334T2

公开(公告)日：2004-06-24

申请号：DE60005334

申请日：2000-05-31

Applicant: ABBOTT LAB

Inventor： PHAN LY T ,  OR YAT SUN ,  MA ZHENKUN ,  CHEN YAN

IPC: A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  A61K31/7048

公开(公告)号：NO20002190D0

公开(公告)日：2000-04-27

申请号：NO20002190

申请日：2000-04-27

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C07H

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：BRPI0716438B1

公开(公告)日：2022-01-25

申请号：BRPI0716438

申请日：2007-09-07

Applicant: ABBOTT LAB ,  ABBVIE BAHAMAS LTD ,  ABBVIE INC

Inventor： WU CHENGBIN ,  CAROLYN A CUFF ,  YING HUA ,  JONATHAN P BELK ,  MARIA A ARGIRIADI ,  PAUL R HINTON ,  RICHARD W DIXON ,  KUMAR SHANKAR ,  TERRY L MELIM ,  CHEN YAN

IPC: C07H21/00 ,  C12P21/08

Abstract: proteínas ligantes a interleucina-13, anticorpo isolado, construto e conjugado anticorpo, ácido nucléico isolado, vetor célula hospedeira, método para produzir proteína ligante, composição e uso. a presente invenção abrange proteínas ligantes a il-13. especificamente, a invenção está relacionada a anticorpos que são quiméricos, enxertados de cdr e anticorpos humanizados. os anticorpos preferidos têm alta afinidade para hil-13 e neutralizam a atividade da hil-13 in e in vivo anticorpo da invenção pode ser um anticorpo de comprimento completo ou uma sua parte antígeno-ligante. método de produzir e o método de utilizar os anticorpos da invenção são também providos. os anticorpos, ou porção anticorpos, da invenção são úteis para detectar hil-13 e para inibir a ativ da hil-13 atividade, por exemplo, em um individuo humano que sofre de um distúrbio em que a atividade da hil-13 é prejudicial.

公开(公告)号：ZA200901526B

公开(公告)日：2018-11-28

申请号：ZA200901526

申请日：2009-03-03

Applicant: ABBOTT LAB

Inventor： MELIM TERRY L ,  CUFF CAROLYN A ,  ARGIRIADI MARIA A ,  WU CHENGBIN ,  HINTON PAUL R ,  DIXON RICHARD W ,  KUMAR SHANKAR ,  BELK JONATHAN P ,  CHEN YAN ,  YING HUANG

Abstract: The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.

公开(公告)号：CA2662701C

公开(公告)日：2015-12-08

申请号：CA2662701

申请日：2007-09-07

Applicant: ABBOTT LAB

Inventor： WU CHENGBIN ,  DIXON RICHARD W ,  BELK JONATHAN P ,  YING HUA ,  ARGIRIADI MARIA A ,  CUFF CAROLYN A ,  HINTON PAUL R ,  KUMAR SHANKAR ,  MELIM TERRY L ,  CHEN YAN

IPC: C07K16/24 ,  A61K39/395 ,  A61K47/48 ,  A61K49/00 ,  A61K51/10 ,  C07K16/46 ,  C12N15/13 ,  C12N15/63 ,  C12P21/08

Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.