公开(公告)号：HK1093727A1

公开(公告)日：2007-03-09

申请号：HK06112524

申请日：2006-11-14

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA M ROBERT ,  CINK RUSSEL D

IPC: A61K20090101 ,  A61P20090101 ,  A61P13/10 ,  C07C20090101 ,  C07D20090101 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt thereof (in which X 1 - X 5 , R 5 - R 8b , Z 1 - Z 2 and Ar 1 are defined herein), pharmaceutical compositions including those compounds and a process for making those compounds. The compounds of formula (I) are useful for treating pain, bladder overreactivity, urinary incontinence, inflammatory hyperalgesia by inhibiting the VR1 receptor in mammals.

公开(公告)号：BRPI0412438A

公开(公告)日：2006-09-05

申请号：BRPI0412438

申请日：2004-07-09

Applicant: ABBOTT LAB

Inventor： ZHENG GUO ZHU ,  BROWN BRIAN S ,  TURNER SEAN C ,  WHITE TAMMIE K ,  SCHMIDT ROBERT G ,  KOENIG JOHN R ,  LEE CHIH-HUNG

IPC: A61P25/04 ,  C07D401/04 ,  C07D487/08 ,  C07D401/12 ,  A61K31/4525

Abstract: The present invention relates to compounds of formula (I) that useful in treating pain.

公开(公告)号：CA2539967A1

公开(公告)日：2005-05-06

申请号：CA2539967

申请日：2004-10-12

Applicant: ABBOTT LAB

Inventor： KOENIG JOHN R ,  BROWN BRIAN S ,  LANCE CHIH-HUNG

IPC: C07D213/56 ,  A61K31/33 ,  A61K31/444 ,  A61P13/00 ,  A61P25/06 ,  A61P29/02 ,  C07D213/61 ,  C07D213/73 ,  C07D213/75 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85 ,  C07D231/12 ,  C07D231/40 ,  C07D233/54 ,  C07D233/64 ,  C07D233/88 ,  C07D239/26 ,  C07D257/04 ,  C07D257/06 ,  C07D261/08 ,  C07D261/14 ,  C07D263/48 ,  C07D277/30 ,  C07D277/46 ,  C07D333/24 ,  C07D333/36 ,  C07D401/12 ,  C07D521/00

Abstract: The present invention relates to compounds of formula (I), that are novel VR 1 antagonists useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.

公开(公告)号：AU2004265306A1

公开(公告)日：2005-02-24

申请号：AU2004265306

申请日：2004-08-04

Applicant: ABBOTT LAB ,  LEE CHIH HUNG

Inventor： GOMTSYAN ARTHUR R ,  WHITE TAMMIE K ,  DRIZIN IRENE ,  KOENIG JOHN R ,  SCHMIDT ROBERT G JR ,  BAYBURT EROL K ,  TURNER SEAN C ,  PENNER RICHARD J ,  ZHENG GUO ZHU ,  DIDOMENICO STANLEY JR

IPC: C07D217/24 ,  A61K31/47 ,  A61K31/472 ,  A61K31/496 ,  A61K31/5377 ,  C07D209/08 ,  C07D217/02 ,  C07D217/22 ,  C07D217/26 ,  C07D231/56 ,  C07D237/28 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D451/02 ,  C07D521/00

Abstract: Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity, wherein X 1 , X 2 , X 3 , X 4 , X 5 , R 5 , R 6 , R 7 , R 8a , R 8b , R 9 , Z 1 , Z 2 and L are as defined in the description.

公开(公告)号：AU2004257220A1

公开(公告)日：2005-01-27

申请号：AU2004257220

申请日：2004-07-09

Applicant: ABBOTT LAB

Inventor： BROWN BRIAN S ,  WHITE TAMMIE K ,  ZHENG GUO ZHU ,  KOENIG JOHN R ,  LEE CHIH-HUNG ,  TURNER SEAN C ,  SCHMIDT ROBERT G

IPC: C07D401/04 ,  A61K31/4525 ,  A61K31/4995 ,  A61P25/04 ,  C07D401/12 ,  C07D487/08

Abstract: The present invention relates to compounds of formula (I) that useful in treating pain.

公开(公告)号：CA2756058A1

公开(公告)日：2004-12-23

申请号：CA2756058

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA ROBERT M ,  CINK RUSSELL D

IPC: C07D403/12 ,  A61K31/416 ,  A61P13/10 ,  A61P29/00 ,  C07C209/24 ,  C07C211/42 ,  C07D217/02 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14

Abstract: The present invention discloses novel compounds of general formula (I), or a pharmaceutically acceptable salt or prodrug thereof (in which X1 - X5, R5 -R8b, Z1 - Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.

公开(公告)号：CY1111945T1

公开(公告)日：2015-11-04

申请号：CY111100738

申请日：2011-07-28

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  HSU MARGARET ,  LEANNA ROBERT M ,  CINK RUSSEL D

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

Abstract: Ηπαρούσαεφεύρεσηγνωστοποιείνέεςενώσειςτουγενικούτύπου (I), ήέναφαρμακευτικώςαποδεκτόάλαςαυτών (στιςοποίες X1-Χ5, R5-R8b, Ζ1-Ζ2 καιΑr1 ορίζονταιστοπαρόν), φαρμακευτικέςσυνθέσειςοιοποίεςπεριλαμβάνουναυτέςτιςενώσειςκαιμιαδιαδικασίαγιαπαρασκευήαυτώντωνενώσεων. Οιενώσειςτουτύπου (I) είναιχρήσιμεςγιααντιμετώπισηάλγους, υπερδραστηριότηταςτηςουροδόχουκύστης, ουρικήςακράτειας, φλεγμονώδουςυπεραλγησίαςμέσωαναστολήςτου VR1 υποδοχέασεθηλαστικά.

公开(公告)号：NZ567358A

公开(公告)日：2011-10-28

申请号：NZ56735806

申请日：2006-10-27

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR R ,  BAYBURT EROL K ,  KOENIG JOHN R ,  MARSH KENNAN C ,  SCHMIDT ROBERT G ,  LEE

IPC: C07D231/56 ,  A61K31/416 ,  A61P13/00 ,  C07D407/12

Abstract: Disclosed are indazole derivatives of formula (I), wherein the variables A, R1, R2, and R3 are as defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.

公开(公告)号：DK2017265T3

公开(公告)日：2011-09-19

申请号：DK08166079

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： GOMTSYAN ARTHUR ,  BAYBURT EROL K ,  LEE CHIH-HUNG ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  LEANNA ROBERT M ,  CINK RUSSEL D ,  HSU MARGARET

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12

公开(公告)号：PT2017265E

公开(公告)日：2011-07-29

申请号：PT08166079

申请日：2004-06-10

Applicant: ABBOTT LAB

Inventor： LEE CHIH-HUNG ,  BAYBURT EROL K ,  GOMTSYAN ARTHUR ,  KOENIG JOHN R ,  SCHMIDT ROBERT ,  LUKIN KIRILL ,  CHAMBOURNIER GILLES ,  CINK RUSSEL D ,  HSU MARGARET ,  LEANNA ROBERT M

IPC: C07D217/02 ,  A61K31/416 ,  A61K31/472 ,  A61P13/10 ,  C07C211/42 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12