公开(公告)号：DK276289D0

公开(公告)日：1989-06-06

申请号：DK276289

申请日：1989-06-06

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  LARTEY PAUL A ,  MARING CLARENCE J ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：ES2196331T3

公开(公告)日：2003-12-16

申请号：ES97922483

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  CURTY CYNTHIA BRUNELL ,  FAGHIH RAMIN ,  NELLANS HUGH NERBY ,  PETERSEN ALBERT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：DK1021456T3

公开(公告)日：2003-08-18

申请号：DK97922483

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  CURTY CYNTHIA BRUNELL ,  FAGHIH RAMIN ,  NELLANS HUGH NERBY ,  PETERSEN ALBERT CHRISTIAN

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having the Formula (I) (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：AT180406T

公开(公告)日：1999-06-15

申请号：AT94923344

申请日：1994-07-06

Applicant: ABBOTT LAB

Inventor： EDWARDS CARLA ,  LARTEY PAUL A

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

Abstract: Antibacterial compounds having the formula and pharmaceutically acceptable salts thereof, wherein Y is selected from isting of -C(O)-, -C(S)-, -CH2-, -CH2CH2- and -C(CH3)2-; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same and methods for their use.

公开(公告)号：HK1010054A1

公开(公告)日：1999-06-11

申请号：HK98110890

申请日：1998-09-23

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08 ,  C07H ,  A61K

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：DK0623021T3

公开(公告)日：1999-02-08

申请号：DK93904533

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

公开(公告)号：CA2257361A1

公开(公告)日：1997-12-24

申请号：CA2257361

申请日：1997-04-25

Applicant: ABBOTT LAB

Inventor： NELLANS HUGH NERBY ,  FAGHIH RAMIN ,  PETERSEN ALBERT CHRISTIAN ,  LARTEY PAUL A ,  CURTY CYNTHIA BURNELL

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/04 ,  A61P1/12 ,  A61P1/18 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07H17/08

Abstract: Novel macrocyclic 13-membered ring-contracted compounds derived from erythromycins A and B having formula (I) and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3 and X are specifically defined, having use in treating gastrointestinal disorders associated with hypermotilinemia, pharmaceutical compositions thereof, a method of treating gastrointestinal disorders associated with hypermotilinemia with said pharmaceutical compositions, and processes for the preparation thereof.

公开(公告)号：MX9705136A

公开(公告)日：1997-10-31

申请号：MX9705136

申请日：1996-01-03

Applicant: ABBOTT LAB

Inventor： ALDER LISA A ,  BURRES NEAL S ,  HOCHLOWSKI JILL E ,  JACKSON MARIANNA ,  MCALPINE JAMES B ,  KLEIN LARRY L ,  LARTEY PAUL A ,  YEUNG CLINTON

IPC: C12P17/06 ,  A01N43/16 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/10 ,  C07H15/10 ,  C07H17/04 ,  C12R1/645

Abstract: Agentes antifungales novedosos que tienen la formula (I), en donde R es hidrogeno o -C(O)-R1, en donde R1 es alquenilo, alquilo de 2 a 12 átomos de carbono, arilo, arilalquenilo, arilalquilo, arilo-arilo-, arilalcoxi-arilo-, ariloxi-arilo, arilo-arilo-arilo-, o arilalcoxi-arilo-arilo-, o sales, ésteres o profármacos farmacéuticamente aceptables de los mismos, así como (i) composiciones farmacéuticas que comprenden tales compuestos, (ii) métodos de tratamiento usando tales compuestos, y (iv) métodos y cultivos fungales utiles en la fabricacion de los mismos.

公开(公告)号：ES2103257T3

公开(公告)日：1997-09-16

申请号：ES89109890

申请日：1989-06-01

Applicant: ABBOTT LAB

Inventor： PARIZA RICHARD J ,  MARING CLARENCE J ,  LARTEY PAUL A ,  KLEIN LARRY L

IPC: A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08 ,  C07H19/04

Abstract: Semisynthetic antibiotics with improved therapeutic properties are disclosed. In particular, 9-R-azacyclic derivatives of erythromycin, its derivatives, and their salts and esters show superior antimicrobial activity compared to other macrolide compounds.

公开(公告)号：AU656462B2

公开(公告)日：1995-02-02

申请号：AU3586193

申请日：1993-01-19

Applicant: ABBOTT LAB

Inventor： LARTEY PAUL A ,  NELLANS HUGH N ,  KLEIN LARRY L ,  FAGHIH RAMIN

IPC: A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P1/00 ,  A61P1/08 ,  A61P1/10 ,  A61P31/04 ,  C07D233/22 ,  C07H17/08 ,  A61K31/71

Abstract: 4''-Deoxy derivatives of erythromycin having the Formula (I) (I) and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.