公开(公告)号：ES2307511T3

公开(公告)日：2008-12-01

申请号：ES00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT SUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compuesto seleccionado del grupo que consiste en un compuesto de fórmula (I) (Ver fórmula) un compuesto de fórmula (II) (Ver fórmula) y un compuesto de fórmula (III) (Ver fórmula) y sus sales, ésteres, y profármacos farmacéuticamente aceptables, donde, en las fórmulas (I)-(III), Y y Z se seleccionan juntos del grupo que consiste en (1) oxo, (2) =N-OH, (3) =N-OR 1 donde R 1 se selecciona del grupo que consiste en (a) -alquilo C1-C12, (b) -alquilo C1-C12 sustituido con arilo, (c) -alquilo C1-C12 sustituido con arilo sustituido, (d) -alquilo C1-C12 sustituido con heteroarilo...

公开(公告)号：DE60039238D1

公开(公告)日：2008-07-31

申请号：DE60039238

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT SUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

公开(公告)号：CA2307788C

公开(公告)日：2008-05-20

申请号：CA2307788

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  CLARK RICHARD F ,  CHEN YAN ,  PLATTNER JACOB J

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention , and processes for their preparation.

公开(公告)号：PL191453B1

公开(公告)日：2006-05-31

申请号：PL34029098

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04

公开(公告)号：CA2235942C

公开(公告)日：2005-12-06

申请号：CA2235942

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  ELLIOTT RICHARD L ,  CHU DANIEL T ,  HALLAS ROBERT ,  OR YAT SUN ,  SPINA KENNETH P

IPC: A61K31/70 ,  C07H17/08 ,  C07H23/00

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R1, R2 and Z are specificall y defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：DK1027362T3

公开(公告)日：2005-10-31

申请号：DK98956338

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： OR YAT SUN ,  CHU DANIEL T ,  PHAN LY TAM ,  PLATTNER JACOB J ,  CLARK RICHARD F ,  CHEN YAN

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：AT298760T

公开(公告)日：2005-07-15

申请号：AT98956338

申请日：1998-10-29

Applicant: ABBOTT LAB

Inventor： PHAN LY TAM ,  OR YAT SUN ,  CHU DANIEL T ,  PLATTNER JACOB J ,  CHEN YAN ,  CLARK RICHARD F

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Novel 2-halo-6-O-substituted ketolide derivatives and pharmaceutically acceptable salts and esters thereof having antibacterial activity having formula (I) or (II), compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for their preparation.

公开(公告)号：PT876388E

公开(公告)日：2004-07-30

申请号：PT96936579

申请日：1996-10-17

Applicant: ABBOTT LAB

Inventor： SPINA KENNETH P ,  HALLAS ROBERT ,  EDELSON RICHARD L ,  CHU DANIEL T ,  OR YAT SUN ,  PHAN LY TAM

IPC: C07H17/00 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7042 ,  A61P31/00 ,  A61P31/04 ,  C07H17/08

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulae (I); (II); (III) or (IV) wherein A, B, D and E, R , R and Z are specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of antibacterial infections with such compositions, and processes for the preparation of the compounds.

公开(公告)号：PE05222002A1

公开(公告)日：2002-06-25

申请号：PE0010212001

申请日：2001-10-15

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  PHAN LY TAM ,  ZHANG SUOMING ,  DJURIC STEVAN ,  CLARK RICHARD F

IPC: A61K31/7048 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: SE REFIERE A DERIVADOS DE ERITROMICINA (CETOLIDOS 6-O-SUSTITUIDOS) DE FORMULA I DONDE A1 ES ARILO, HETEROARILO; Y1 ES ISOXAZOL, OXAZOL, ISOTIAZOL, DIHIDROISOXAZOL, DIHIDROOXAZOL; D1 ES HC-CH; C C; R1 ES H, Rp; Rp ES UN GRUPO PROTECTOR DE OH. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS SIN PRODUCIR EL EFECTO COLATERAL DE INTOLERANCIA INTESTINAL COMO NAUSEAS, VOMITOS

公开(公告)号：CA2391297A1

公开(公告)日：2001-06-07

申请号：CA2391297

申请日：2000-12-01

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT SUN ,  PHAN LY TAM

IPC: A61K31/7052 ,  A61K31/7056 ,  A61P31/04 ,  C07H17/08 ,  C07H17/00

Abstract: The present invention relates to 6-O-alkyl-2-nor-2-substituted ketolide compound or a derivative thereof, a composition comprising the compound and a suitable carrier, a method of preparing the compound, and a method of treatment and prevention of in mammals comprising administering said compoun d.