公开(公告)号：EP2820009A1

公开(公告)日：2015-01-07

申请号：EP13710222.4

申请日：2013-03-01

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHICARELLI, Mark Joseph ,  GARREY, Rustam Ferdinand ,  GAUDINO, John ,  GRINA, Jonas ,  MORENO, David A. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  ROBARGE, Kirk ,  ZHOU, Aihe

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/65586

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 提供式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐，其可用于治疗过度增殖性疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。

公开(公告)号：EP2265610B1

公开(公告)日：2012-12-12

申请号：EP09718306.5

申请日：2009-02-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  DE MEESE, Jason ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  LUNGHOFER, Paul ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  SEO, Jeongbeob ,  TIAN, Hongqi ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07C311/08

公开(公告)号：EP2493865A2

公开(公告)日：2012-09-05

申请号：EP10805862.9

申请日：2010-08-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： ALIAGAS, Ignacio ,  GRADL, Stefan ,  GUNZNER, Janet ,  LEE, Wendy ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  ZHAO, Guiling ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

IPC: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D405/12 ,  C07D471/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof,
for in vitro, in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract translation: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物及其立体异构体，互变异构体，前药和药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的这些病症或相关病理学病症的方法。

公开(公告)号：EP2470532A1

公开(公告)日：2012-07-04

申请号：EP10749745.5

申请日：2010-08-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： GRADL, Stefan ,  LAIRD, Ellen ,  MORENO, David ,  REN, Li ,  WENGLOWSKY, Steven Mark

IPC: C07D471/04 ,  A61K31/437 ,  A61P13/12 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. [FORMULA I]

公开(公告)号：EP1934228A2

公开(公告)日：2008-06-25

申请号：EP06813989.8

申请日：2006-08-31

Applicant: Array Biopharma, Inc.

Inventor： MIKNIS, Greg ,  LYSSIKATOS, Joseph P. ,  LAIRD, Ellen ,  TARLTON, Eugene ,  BUCKMELTER, Alexandre J. ,  REN, Li ,  RAST, Bryson ,  SCHLACTER, Stephen T. ,  WENGLOWSKY, Steven Mark

IPC: C07D495/04 ,  C07D491/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Compounds of Formula I are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP3740490A1

公开(公告)日：2020-11-25

申请号：EP19703591.8

申请日：2019-01-18

Applicant: Array Biopharma, Inc.

Inventor： BLAKE, James F. ,  DAI, Donghua ,  HAAS, Julia ,  JIANG, Yutong ,  KOLAKOWSKI,, Gabrielle R. ,  METCALF, Andrew T. ,  MORENO, David A. ,  PRIGARO, Brett ,  REN, Li

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/519

公开(公告)号：EP2820009B1

公开(公告)日：2018-01-31

申请号：EP13710222.4

申请日：2013-03-01

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James F. ,  CHICARELLI, Mark Joseph ,  GARREY, Rustam Ferdinand ,  GAUDINO, John ,  GRINA, Jonas ,  MORENO, David A. ,  MOHR, Peter J. ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  ROBARGE, Kirk ,  ZHOU, Aihe

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/6558 ,  C07F9/6596 ,  A61K31/435 ,  A61K31/506 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D401/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/513 ,  A61K31/53 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F9/65586

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP3089980A1

公开(公告)日：2016-11-09

申请号：EP14827387.3

申请日：2014-12-29

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： BLAKE, James, F. ,  COOK, Adam ,  GAUDINO, John ,  GUNAWARDANA, Indrani, W. ,  HICKEN, Erik, James ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  GAZZARD, Lewis ,  SCHMIDT, Jane ,  DO, Steve

IPC: C07D487/04 ,  A61K31/444 ,  A61K31/506 ,  A61P29/00

CPC classification number: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

Abstract translation: 提供式I化合物或其立体异构体，互变异构体或药学上可接受的盐，其可用于治疗疾病。 公开了使用式I化合物或其立体异构体，互变异构体或药学上可接受的盐在体外，原位和体内诊断，预防或治疗这些疾病或相关病理学病症的方法。

公开(公告)号：EP2265609A1

公开(公告)日：2010-12-29

申请号：EP09716688.8

申请日：2009-02-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： AHRENDT, Kateri, A. ,  BUCKMELTER, Alexandre, J. ,  GRINA, Jonas ,  HANSEN, Joshua, D. ,  LAIRD, Ellen, R. ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven, M. ,  FENG, Bainian ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy, B. ,  MORENO, David, A.

IPC: C07D471/04 ,  C07C311/08 ,  A61K31/437 ,  A61P35/00 ,  A61P13/12

CPC classification number: C07D471/04 ,  C07C311/48

Abstract: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for
in vitro ,
in situ , and
in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP2265608A2

公开(公告)日：2010-12-29

申请号：EP09716491.7

申请日：2009-02-27

Applicant: Array Biopharma, Inc. ,  Genentech, Inc.

Inventor： AHRENDT, Kateri A. ,  BUCKMELTER, Alexandre J. ,  GRINA, Jonas ,  HANSEN, Joshua D. ,  LAIRD, Ellen R. ,  MORENO, David ,  NEWHOUSE, Brad ,  REN, Li ,  WENGLOWSKY, Steven Mark ,  FENG, Bainian ,  GUNZNER, Janet ,  MALESKY, Kim ,  MATHIEU, Simon ,  RUDOLPH, Joachim ,  WEN, Zhaoyang ,  YOUNG, Wendy B.

IPC: C07D471/04

CPC classification number: C07D471/04 ,  C07C311/08

Abstract: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.