公开(公告)号：NO810761A

公开(公告)日：1981-09-09

申请号：NO810761

申请日：1981-03-05

Applicant: BASF AG

Inventor： STEINER GERD ,  HOFMAN HANS PETER ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  LENKE DIETER

IPC: C07D295/14 ,  A61K31/275 ,  A61K31/395 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155 ,  C07D

CPC classification number: C07D295/155 ,  C07D243/08

公开(公告)号：CA1105023A

公开(公告)日：1981-07-14

申请号：CA305369

申请日：1978-06-13

Applicant: BASF AG

Inventor： BINNIG FRITZ ,  FRIEDRICH LUDWIG ,  HOFMANN HANS P ,  KREISKOTT HORST ,  MUELLER CLAUS ,  RASCHACK MANFRED

IPC: A61K31/435 ,  A61K31/445 ,  A61P9/06 ,  C07D221/00 ,  C07D471/08

Abstract: This invention relates to bispidine derivatives of the formula where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, with the proviso that R1, R2 and R3 cannot all be H when X is 0. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzyl-piperid-4-one with appropriately substituted phenylalkylamines, followed by redustion. They exhibit mainly anto-arrhythmic action.

公开(公告)号：BG62067B2

公开(公告)日：1999-01-29

申请号：BG9860394

申请日：1994-02-28

Applicant: BASF AG

Inventor： SCHLECKER RAINER ,  SCHMIDT PETER ,  THIEME PETER C ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN ,  MUELLER CLAUS D ,  HOFMANN HANS P ,  KREISKOTT HORST

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80

Abstract: The esters of the hydroxycoumarins with sulphonic acids havethe formulawhere R1 and R2, which may be the same or different, meanhydrogen, halogen, preferably chloro- or alkyl residue with 1 to 5carbon atoms which can be substituted by -NR4R5, -OR4, -CO2R4,where R4 & R5 are the same or different and mean hydrogen atom oralkyl residue with 1 to 4 carbon atoms, or is a group ofcarboxylic acid -CO2R4, provided that R1 is not hydrogen andmethyl. when R2 means hydrogen, or together form -(CH2)n-chain,and n has the value of from 3 to 5, and R3 is alkyl residue with astraight or a branching chain with 1 to 8 carbon atoms orcyloalkyl residue with 3 to 8 carbon atoms which optionally can besubstituted by halogen, -OR3, -NR4R5, -CN or phenyl ring, alkylresidue with a straight or branching chain with 3 to 3 carbonatoms or aminogroup -NR4R5, or means a phenyl or naphthyl residuewhich optionally is mono- or polysubstituted by -OR4, -NR3R5,-NO2, halogen, -SR4, -SOR4, -SO2R4, -SCF3, -SP2CF3, -CN, -CO2R4,-COR4, -NHCOR4, -CF3, C1-C4 alkyl residue or combination of thesesubstituents. The invention also relates to method for thepreparation of the above esters and to their usage as activecomponents of pharmaceutical preparations which are valuablemedicamentous forms in the treatment of psychic disorders.6 claims

公开(公告)号：CA1249589A

公开(公告)日：1989-01-31

申请号：CA441801

申请日：1983-11-23

Applicant: BASF AG

Inventor： SEITZ WERNER ,  TESCHENDORF HANS-JUERGEN ,  MICHEL ALFRED ,  TRAUT MARTIN ,  HOFMANN HANS P ,  KREISKOTT HORST

IPC: C07C225/18 ,  A61K31/135 ,  A61K31/205 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07D207/08 ,  C07D211/32 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/145 ,  C07C97/10

Abstract: 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2, 3,4-tetrahydronaphthalenes of the formula I I where R1 and R2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C1-C4-alkyl or C1C4-alkoxy, R3 is C1-C6-alkyl and R4 is hydrogen, C1C6-alkyl or benzyl, or R3 and R4 together may furthermore be a C2-C5-alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described. These novel compounds are useful active compounds for treating disorders.

公开(公告)号：FI71132B

公开(公告)日：1986-08-14

申请号：FI801228

申请日：1980-04-17

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D401/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：CA1209136A

公开(公告)日：1986-08-05

申请号：CA441470

申请日：1983-11-18

Applicant: BASF AG

Inventor： TREIBER HANS J ,  HOFMANN HANS P ,  KREISKOTT HORST ,  TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN

IPC: A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D267/08 ,  C07D267/10

Abstract: 7-phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepines of the formula I where R1 is hydrogen, chlorine or methoxy and R2 is hydrogen or methyl, and their salts with physiologically tolerated acids, and their preparation, are described. The substances are useful for treating depression.

公开(公告)号：NO153495C

公开(公告)日：1986-05-14

申请号：NO801387

申请日：1980-05-09

Applicant: BASF AG

Inventor： STEINER GERD ,  FRANKE ALBRECHT ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  WORSTMANN WOLFAGANG ,  KREISKOTT HORST

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：HUT36783A

公开(公告)日：1985-10-28

申请号：HU459284

申请日：1984-12-10

Applicant: BASF AG

Inventor： RASCHACK MANFRED ,  KREISKOTT HORST ,  SEITZ WERNER

IPC: C07B57/00 ,  A61K20060101 ,  A61K31/275 ,  A61P9/00 ,  C07B31/00 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C07C255/32 ,  C07C255/42 ,  C07C255/58 ,  C07D20060101 ,  C07C121/66

Abstract: 1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane and its antipodes and salts are used for the treatment of diseases.

公开(公告)号：ZA838692B

公开(公告)日：1984-07-25

申请号：ZA838692

申请日：1983-11-22

Applicant: BASF AG

Inventor： SCHLECKER RAINER ,  SCHMIDT PETER ,  THIEME PETER C ,  LENKE DIETER ,  TESCHENDORF HANS-JUERGEN ,  TRAUT MARTIN ,  MUELLER CLAUS D ,  HOFMANN HANS-PETER ,  KREISKOTT HORST

IPC: A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K31/37 ,  A61P25/18 ,  A61P25/24 ,  A61P25/26 ,  A61P37/08 ,  A61P43/00 ,  C07D311/08 ,  C07D311/16 ,  C07D311/78 ,  C07D311/80 ,  A61K ,  C07D

Abstract: Sulfonates of hydroxycoumarins of the formula I (I) where R1 and R2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by -NR4R5, -OR4 or -OC(O)R4, where R4 and R5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R1 and R2 are each a carboxylic acid group -OC(O)R4 or a carboxamido radical, with the proviso that R1 is not methyl when R2 is hydrogen, or R1 and R2 together form a -(CH2)n- chain where n is 3-5, and R3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, -OR4, -NR4R5, -CN or phenyl, or R3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group - NR4R5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by -OR4, -NR4R5, -NO2, halogen, -SR4, -S(O)R4, -OS(O)R4, -SCF3, -OS(O)CF3, -CN, -C(O)R4, -OC(O)R4, -NHC(O)R4, -CF3, C1-C4-alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R1 is methyl and R2 is hydrogen, for use as drugs.

公开(公告)号：ZA816927B

公开(公告)日：1982-10-27

申请号：ZA816927

申请日：1981-10-07

Applicant: BASF AG

Inventor： STEINER GERD ,  TESCHENDORF HANS JUERGEN ,  KREISKOTT HORST ,  HOFMANN HANS PETER

IPC: A61K31/55 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D223/00 ,  C07D333/00 ,  C07D495/14 ,  C07D