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    44.
    发明专利
    未知

    公开(公告)号：AT113028T

    公开(公告)日：1994-11-15

    申请号：AT89113379

    申请日：1989-07-21

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  RASCHACK MANFRED DR ,  VON PHILIPSBORN GERDA DR

    IPC: A61K31/135 ,  A61K31/13 ,  A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61P9/06 ,  C07C217/22 ,  C07D295/08 ,  C07D295/092

    Abstract: p-Hydroxyphenone derivatives of the general formula I … … in which R , R and R are identical or different and are methyl, chlorine, bromine and hydrogen, where R , R and R are not all H, R and R are identical or different and are H, C1-C4-alkyl or OR , where R and R are not both H, X is a -CH=CH-, -CH2CH2- and -CH2-bridge, Y is a straight-chain or branched, saturated or unsaturated C1-C4-bridge and Z is the radical NR R , where R and R are, independently of one another, hydrogen or C1-C4-alkyl, or Z is a 5- or 6-membered ring with a nitrogen atom in position 1 and, where appropriate, additionally a second N or an O or S atom, where the second N atom is substituted by R , the physiologically tolerated salts thereof, and medicaments prepared therefrom and the use thereof as Vaughan-Williams Class III antiarrhythmic.

    46.
    发明专利
    未知

    公开(公告)号：DE4217952A1

    公开(公告)日：1993-12-02

    申请号：DE4217952

    申请日：1992-05-30

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  BEHL BERTHOLD DR

    IPC: A61K31/495 ,  A61K31/498 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D403/04 ,  C07D487/12 ,  C07D487/14 ,  C07D207/30

    Abstract: Quinoxaline-2,3-(1H,4H)diones of the general formula I in which the variables have the following meaning: R is hydrogen; an aliphatic radical having up to 12 C atoms, which can carry one of the following substituents: phenyl, cyclopentyl, cyclohexyl or a group -CO-R , -CO-O-R or -CO-NH-R , where R denotes hydrogen, C1-C4-alkyl, phenyl, benzyl or 1-phenylethyl; a cycloaliphatic radical having up to 12 C atoms, or a phenyl group, where the cyclic groups contained in R can carry up to three of the following substituents: C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, halogen, nitro, cyano, -CO-O-R and -CO-NH-R ; R is a pyrrol-1-yl group which can carry up to two of the following substituents: C1-C4-alkyl, phenyl, phenylsulphonyl, nitro, cyano and one of the groups -CO-O-R , -CO-NH-R , -CH2-O-R , -O-R and -CH=NO-R ; R is identical or different radicals from the following: C1-C4-alkyl, C1-C4-alkoxy, trifluoromethyl, trichloromethyl, trifluoromethoxy, trichloromethoxy, fluorine, chlorine, bromine, iodine, nitro, cyano and one of the groups -CO-O-R and -CO-NH-R and a fused benzene ring; n is 0 to 3. Quinoxaline-2,3-(1H,4H)diones I' in which R has the meaning mentioned. The compounds I and I' are suitable as medicines for human and veterinary medicine.

    48.
    发明专利
    未知

    公开(公告)号：DE3732094A1

    公开(公告)日：1989-04-06

    申请号：DE3732094

    申请日：1987-09-24

    Applicant: BASF AG

    Inventor： LUBISCH WILFRIED DR ,  BINNIG FRITZ DR ,  PHILIPSBORN GERDA VON DR MED

    IPC: A61K31/435 ,  A61K31/44 ,  A61P9/06 ,  C07D471/08

    Abstract: Bispidine derivatives of the formula I I where R, R1 and R3 are identical or different and are each H, C1-C4-alkyl, halogen or C1-C4-alkoxy, when Y is R2 is C1-C4-alkyl, halogen, -CN, C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR4R5 where R4 and R5 are each C1-C4-alkyl, when Y is R2 is C1-C4-alkyl, halogen, -CN1C1-C4-alkoxy, -NHSO2CH3, -CF3, NH-acetyl or -NR9R10 where R9 is C1-C4-alkyl and R10 is H or C1-C4-alkyl, and when X is not CH2 R2 may also be NO2 or NH2, X is -CH2-, -C(O)- or -C(R6)OR7- (where R6 is H or C1-C4-alkyl and R7 is H, C1-C4-alkyl or where R8 is H, C1-C4-alkyl, halogen or C1 -C4-alkoxy), Y is -C(O) or -CONH- and Z is C1-C4-alkylene which may be olefinically unsaturated and/or branched, and their physiologically tolerated salts, and drugs containing these compounds as active compounds are described.

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