公开(公告)号：HUT77000A

公开(公告)日：1998-01-28

申请号：HU9700225

申请日：1995-07-24

Applicant: BASF AG

Inventor： DEYN WOLFGANG ,  ENGEL STEFAN ,  GERBER MATTHIAS ,  KARDORFF UWE ,  KAST JUERGEN ,  NUEBLING CHRISTOPH ,  PLATH PETER ,  WALTER HELMUT ,  WESTPHALEN KARL-OTTO

IPC: A01N43/60 ,  A01N43/76 ,  A01N43/78 ,  C07D241/18 ,  A01P13/00 ,  C07D241/24 ,  C07D413/04 ,  C07D417/04

Abstract: PCT No. PCT/EP95/02924 Sec. 371 Date Mar. 20, 1997 Sec. 102(e) Date Mar. 20, 1997 PCT Filed Jul. 24, 1995 PCT Pub. No. WO96/03391 PCT Pub. Date Feb. 8, 1996Substituted pyrazine derivatives of the general formula I where X is an oxygen or sulfur atom or a sulfoxyl or sulfonyl group; n is 0, 1 or 2; Z is a group where Y is oxygen or sulfur, R6 is hydrogen, alkyl, alkoxy, halogen or haloalkyl and p is 0 or 1; and R1, R2, R3, R4 and R5 have the meanings stated in claim 1, and agriculturally useful salts of the compounds I are useful in herbicides.

公开(公告)号：CA2170059A1

公开(公告)日：1995-03-30

申请号：CA2170059

申请日：1994-09-16

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  HAUER BERNHARD ,  LADNER WOLFGANG ,  PRESSLER UWE ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00 ,  C12R1/38 ,  C12P13/00

Abstract: A process for producing optically active primary and secondary amines from the corresponding racemates is characterized in that (a) a racemic amine is enantioselectively acylated in the presence of a hydrolase with an ester whose acid component bears a fluorine, nitrogen, oxygen or sulphur atom at the proximity of the carbonyl carbon atom; (b) the mixture of optically active amine and optically active acylated amine is separated so that an enantiomer of amine is produced; (c) if desired the other enantiomer of the amine is extracted from the acylated amine by amide cleavage.

公开(公告)号：ZA9209128B

公开(公告)日：1994-05-25

申请号：ZA9209128

申请日：1992-11-25

Applicant: BASF AG

Inventor： THEOBALD HANS ,  DEYN WOLFGANG VON ,  NUEBLING CHRISTOPH ,  WALTER HELMUT ,  KARDORFF UWE ,  WESTPHALEN KARL-OTTO ,  KAPPE THOMAS ,  GERBER MATTHIAS

IPC: A01N43/40 ,  A01N43/824 ,  C07D213/82 ,  C07D213/83 ,  C07D ,  A01N

CPC classification number: C07D213/82 ,  A01N43/40 ,  C07D213/83

公开(公告)号：NO324896B1

公开(公告)日：2007-12-27

申请号：NO20013912

申请日：2001-08-10

Applicant: BASF AG

Inventor： HOHN ARTHUR ,  RIECHERS HARTMUT ,  SIMON JOACHIM ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07C209/68 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：EE200300086A

公开(公告)日：2004-12-15

申请号：EEP200300086

申请日：2001-08-30

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUEBLING CHRISTOPH ,  STUERMER RAINER ,  LADNER WOLFGANG

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/16 ,  C12N9/18 ,  C12N15/55 ,  C12P7/62 ,  C12P41/00 ,  C12N1/20 ,  C12N15/63 ,  C12P7/00

Abstract: The invention relates to novel proteins from Pseudomonas glumae, having esterase activity, in particular butynol I esterase activity, to nucleic acid sequences coding therefore, to expression cassettes, vectors and recombinant microorganisms; to methods for preparing said proteins and to the use thereof for enzymic, in particular enantioselective enzymic, ester hydrolysis or transesterification of organic esters.

公开(公告)号：DE59909610D1

公开(公告)日：2004-07-01

申请号：DE59909610

申请日：1999-08-13

Applicant: BASF AG

Inventor： NUEBLING CHRISTOPH ,  DITRICH KLAUS ,  DULLY CHRISTIAN

IPC: C07C213/08 ,  C07C217/08 ,  C12P13/02 ,  C12P41/00

Abstract: The present invention relates to a process for resolving racemates of alkoxy-substituted primary amines by reacting with an ester in the presence of a lipase and subsequently separating the optically active amide which is formed from the unreacted optically active amine. This is followed where appropriate by hydrolysis of the optically active amide, separation of the optically active amine produced thereby from the acid from which the ester is derived, racemization and recycling of the unwanted enantiomer of the amine, and esterification and recycling of the acid.

公开(公告)号：AU769005B2

公开(公告)日：2004-01-15

申请号：AU4140899

申请日：1999-05-10

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/755 ,  C07B55/00 ,  C07B57/00 ,  C07B61/00 ,  C07C209/68 ,  C07C209/88 ,  C07C211/03 ,  C07C213/02 ,  C07C213/08 ,  C07C217/08

Abstract: A process for the preparation of racemic amines of the formula I where R1 and R2 are different and R1, R2, R3 are alkyl, cycloalkyl, arylalkyl, aryl, heteroaryl and heterocyclic radicals and R3 can also be hydrogen, where the radicals can bear substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, aryloxy, amino, alkylamino and dialkylamino, which comprises simultaneously reacting in situ the corresponding optically active amine I and the secondary alcohol of the formula II and/or the unsymmetrical ketone of the formula III and the amine of the formula R3NH2 in the presence of hydrogen and a hydrogenation catalyst or dehydrogenation catalyst at elevated temperature.

公开(公告)号：DE59907224D1

公开(公告)日：2003-11-06

申请号：DE59907224

申请日：1999-04-28

Applicant: BASF AG

Inventor： RIECHERS HARTMUT ,  SIMON JOACHIM ,  HOEHN ARTHUR ,  KRAMER ANDREAS ,  FUNKE FRANK ,  SIEGEL WOLFGANG ,  NUEBLING CHRISTOPH

IPC: B01J23/72 ,  B01J23/755 ,  B01J37/18 ,  C07B55/00 ,  C07B61/00 ,  C07C209/00 ,  C07C209/68 ,  C07C211/00 ,  C07C211/07 ,  C07C213/08 ,  C07C217/08

Abstract: Optically active amines are racemized by reaction of the optically active amine in the gas phase at elevated temperature in the presence of hydrogen and a hydrogenation or dehydrogenation catalyst.

公开(公告)号：DE10131544A1

公开(公告)日：2003-01-16

申请号：DE10131544

申请日：2001-06-29

Applicant: BASF AG

Inventor： HAUER BERNHARD ,  FRIEDRICH THOMAS ,  NUEBLING CHRISTOPH ,  STUERMER RAINER ,  LADNER WOLFGANG

IPC: C12N1/21 ,  C12N9/16 ,  C12N15/55 ,  C12P41/00 ,  C12N9/14

Abstract: A protein (I) with butynol I esterase (BIE) activity comprising at least one of 4 partial sequence polypeptides (S1-4) and their functional equivalents, is new. A protein (I) with butynol I esterase (BIE) activity comprises at least one of 4 partial sequence polypeptides (S1-4) and their functional equivalents. Independent claims are also included for the following: (1) polynucleotides (II) that encode (I), and complementary polynucleotides and sequences that hybridize to them; (2) an expression cassette (EC) comprising at least one (II), operably linked to regulators; (3) a recombinant vector for transforming eukaryotic or prokaryotic hosts, containing (II) or EC; (4) preparation of (I) by culturing organisms that produce (I), either endogenously or after transformation; (5) (I) produced by the method in (4); Pseudomonas glumae Lu2023 (DSM 13176), or its variants or mutants; (6) microorganisms containing the vector of (4); (7) method for enantioselective ester hydrolysis or transesterification using (I); and (8) optically active alcohols, carboxylic acids or esters prepared using (I). Phe-Ile-Glu-Thr-Leu-Gly-Leu-Glu-Arg-Pro-Val-Leu-Val-Gly-His-Ser-Leu-Gl y-Gly-Ala-Ile-Ala-Leu-Ala-Val-Gly-Leu-Asp-Tyr-Pro-Glu-Arg (S1) Ile-Ala-Leu-Ile-Ala-Pro-Leu-Thr-His-Thr-Glu-Thr-Glu-Pro (S2) Gly-Gly-Gly-Met-Met-Gly-Leu-Arg-Pro-Glu-Ala-Phe-Tyr-Ala-Ala-Ser-Ser-As p-Leu-Val (S3) Ala-Ile-Asp-Ala-Ile-Phe-Ala-Pro-Glu-Pro-Val (S4)

公开(公告)号：AT217024T

公开(公告)日：2002-05-15

申请号：AT96900601

申请日：1996-01-20

Applicant: BASF AG

Inventor： BALKENHOHL FRIEDHELM ,  DITRICH KLAUS ,  NUEBLING CHRISTOPH

IPC: C12P13/02 ,  C12P41/00

Abstract: A process for preparing optically active primary and secondary heteroatom-substituted amines from the corresponding racemates, which comprisesa) enantioselective acylation of a racemic heteroatom-substituted amine with an ester whose acid component carries a fluorine, nitrogen, phosphorus, oxygen or sulfur atom in the vicinity of the carbonyl carbon, in the presence of a hydrolase,b) separation of the mixture of optically active heteroatom-substituted amine and optically active acylated heteroatom-substituted amine to obtain one enantiomer of the heteroatom-substituted amine,c) if required isolation of the other enantiomer of the heteroatom-substituted amine from the acylated heteroatom-substituted amine by amide cleavage.