公开(公告)号：CZ9800501A3

公开(公告)日：1998-07-15

申请号：CZ50198

申请日：1996-08-19

Applicant: BASF AG

Inventor： LAY PETER NIKOLAUS ,  RUCK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL DR ,  BAUMGARTEL MICHAEL DR ,  DEMBEK GERHARD DR ,  HAHN KLAUS DR ,  HOLOCH JAN DR ,  HUSEMANN WOLFRAM DR ,  KAEMPFER KNUT DR ,  ZETTLER HANS DIETER

IPC: C08J9/16 ,  B01J13/14 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  B01J19/18 ,  B01J19/24

CPC classification number: C08F12/08

公开(公告)号：CZ50198A3

公开(公告)日：1998-07-15

申请号：CZ50198

申请日：1996-08-19

Applicant: BASF AG

Inventor： LAY PETER NIKOLAUS ,  RUCK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL DR ,  BAUMGARTEL MICHAEL DR ,  DEMBEK GERHARD DR ,  HAHN KLAUS DR ,  HOLOCH JAN DR ,  HUSEMANN WOLFRAM DR ,  KAEMPFER KNUT DR ,  ZETTLER HANS DIETER

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08

Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.

公开(公告)号：ZA968849B

公开(公告)日：1998-04-22

申请号：ZA968849

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：ZA9608849B

公开(公告)日：1998-04-22

申请号：ZA9608849

申请日：1996-10-22

Applicant: BASF AG

Inventor： BREITENBACH JOERG ,  HAERTL AXEL PAUL ,  HOFFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K

CPC classification number: A61J3/10 ,  A61J2200/20 ,  A61K9/209 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/616 ,  B30B11/14 ,  B30B11/16 ,  B30B11/18 ,  B30B11/34 ,  B30B15/308 ,  A61K31/19 ,  A61K2300/00

公开(公告)号：NO981798D0

公开(公告)日：1998-04-22

申请号：NO981798

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH J RG ,  HORTL AXEL PAUL ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61K9/16 ,  A61K9/20

公开(公告)号：NO981793L

公开(公告)日：1998-04-22

申请号：NO981793

申请日：1998-04-22

Applicant: BASF AG

Inventor： BREITENBACH JUERG ,  HORTL AXEL PAUL ,  HOFMANN JUERGEN ,  ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02

Abstract: PCT No. PCT/EP96/04601 Sec. 371 Date Apr. 15, 1998 Sec. 102(e) Date Apr. 15, 1998 PCT Filed Oct. 23, 1996 PCT Pub. No. WO97/15293 PCT Pub. Date May 1, 1997The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.

公开(公告)号：MX9705891A

公开(公告)日：1998-02-28

申请号：MX9705891

申请日：1997-08-01

Applicant: BASF AG

Inventor： WUENSCH JOSEF ,  SCHIESSL MICHAEL ,  DIENER RALPH

IPC: C08F4/642 ,  B01J19/20 ,  B01J19/24 ,  C08F4/659 ,  C08F4/6592 ,  C08F12/04 ,  C08F112/00 ,  C08F112/08 ,  C08F112/02

Abstract: Se preparan polímeros esencialmente sindioticos y semicristalinos que comprenden monomeros vinil aromáticos a partir de una mezcla de reaccion que contiene, como componentes, compuestos vinil aromáticos, complejos de metaloceno como catalizadores y uno o más co-catalizadores seleccionados del grupo que consiste de ácido de Lewis natural fuerte, teniendo los compuestos ionicos cationes ácidos de Lewis y teniendo los compuestos ionicos de Brönsted, como cationes, mediante un proceso en el cual los componentes se premezclan antes de introducirse al reactor.

公开(公告)号：NO980736L

公开(公告)日：1998-02-20

申请号：NO980736

申请日：1998-02-20

Applicant: BASF AG

Inventor： LAY PETER NICOLAUS ,  RUECK SWEN ,  SCHIESSL MICHAEL ,  WITT MICHAEL ,  ZETTLER HANS DIETER ,  BAUMGAERTEL MICHAEL ,  DEMBEK GERHARD ,  HAHN KLAUS ,  HOLOCK JAN ,  HUSEMANN WOLFRAM ,  KAEMPFER KNUT

IPC: C08J9/16 ,  B01J13/14 ,  B01J19/18 ,  B01J19/24 ,  C08F2/02 ,  C08F2/18 ,  C08F12/08 ,  C08F ,  C08J

Abstract: PCT No. PCT/EP96/03633 Sec. 371 Date Jan. 29, 1998 Sec. 102(e) Date Jan. 29, 1998 PCT Filed Aug. 19, 1996 PCT Pub. No. WO97/08231 PCT Pub. Date Mar. 6, 1997A continuous process for preparing bead-form expandable styrene polymers in which the styrene is prepolymerized in bulk to a conversion of 10 to 80%, the prepolymer is dispersed in liquid form in an aqueous phase in the presence of suspension stabilizers, and the polymerization of the prepolymer is completed in an aqueous suspension to a residual styrene content of less than 2000 ppm.

公开(公告)号：CA2209943A1

公开(公告)日：1998-01-23

申请号：CA2209943

申请日：1997-07-08

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  ZETTLER HANS DIETER ,  BREITENBACH JOERG ,  SCHIESSL MICHAEL

IPC: A61J3/10 ,  A61J3/06 ,  A61K9/20 ,  B30B11/22

Abstract: Solid drug forms are produced by mixing and melting at least one pharmacologically acceptable polymeric binder and at least one pharmaceutical active ingredient, with or without conventional pharmaceutical additives, in the absence of a solvent to give a plastic mixture and shaping the mixture to the required drug form by extrusion, where the shaping takes place in two steps, with the extrudate being broken into shaped articles in a first step, and these shaped articles being rounded off in a second step in the plastic state.

公开(公告)号：CA2232356A1

公开(公告)日：1997-05-01

申请号：CA2232356

申请日：1996-10-23

Applicant: BASF AG

Inventor： ROSENBERG JOERG ,  SCHIESSL MICHAEL ,  ZETTLER HANS DIETER ,  HOFMANN JUERGEN ,  BREITENBACH JOERG ,  H RTL AXEL PAUL

IPC: A61J3/10 ,  A61K9/20 ,  A61K9/24 ,  A61K9/28 ,  A61K31/07 ,  A61K31/167 ,  A61K31/192 ,  A61K31/277 ,  A61K31/355 ,  A61K31/375 ,  A61K31/401 ,  A61K31/4422 ,  A61K31/52 ,  A61K31/522 ,  A61K31/60 ,  A61K9/02 ,  A61K31/19 ,  A61K31/275 ,  A61K31/40 ,  A61K31/455

Abstract: The invention concerns a method of producing multi-layer medicaments in solid form for oral or rectal administration. At least two substances, which each comprise a thermoplastic, pharmacologically acceptable polymer binder which is soluble or can swell in a physiological environment, at least one of the substances comprising a pharmaceutical active substance, are coextruded and the coextruded multi-layer material is shaped to form the desired medicament.