公开(公告)号：AT237932T

公开(公告)日：2003-05-15

申请号：AT00936870

申请日：2000-06-07

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAEMER KLAUS ,  SCHWEDEN JUERGEN

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: The invention relates to a method of increasing the flavonoid content of plants by treating the plants with the growth-regulating acylcyclohexadiones according to formula (I).

公开(公告)号：BG106202A

公开(公告)日：2002-06-28

申请号：BG10620201

申请日：2001-12-10

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAEMER KLAUS ,  SCHWEDEN JUERGEN

IPC: A01G7/00 ,  A01N37/42 ,  A61K8/96 ,  A61K8/97 ,  A61K36/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00

Abstract: The invention relates to a method of increasing the flavonoid content of plants by treating the plants with the growth-regulating acylcyclohexadiones according to the formula wherein their substituents have the meanings listed in the description. 6 claims, 4 figures

公开(公告)号：ZA200101328B

公开(公告)日：2002-02-18

申请号：ZA200101328

申请日：2001-02-16

Applicant: BASF AG

Inventor： RADEMACHER WILHELM ,  KRAEMER KLAUS ,  SCHWEDEN JUERGEN ,  HERBERS KARIN

IPC: A23K1/14 ,  A23L1/30 ,  A61K8/96 ,  A61K8/97 ,  A01H5/00 ,  A61K36/00 ,  A61K36/18 ,  A61K36/23 ,  A61K36/48 ,  A61K36/73 ,  A61K36/75 ,  A61K36/81 ,  A61K36/896 ,  A61K36/899 ,  A61P1/14 ,  A61P3/06 ,  A61P29/00 ,  A61P35/00 ,  A61P39/06 ,  A61P43/00 ,  A61Q19/00 ,  C12N5/10 ,  C12N9/02 ,  C12N15/09 ,  C12N15/29 ,  C12N15/53 ,  C12N15/82 ,  C12N ,  A01H ,  A23L ,  A61K

Abstract: The invention relates to a method for increasing flavonoid content in plants. Said method is characterized that a plant is produced using molecular genetic methods in which the activity of enzyme flavanon-3-hydroxylase is reduced.

公开(公告)号：AT192780T

公开(公告)日：2000-05-15

申请号：AT94929554

申请日：1994-10-17

Applicant: BASF AG ,  RHEIN BIOTECH PROZ & PROD GMBH

Inventor： SCHWEDEN JUERGEN ,  BOLLSCHWEILER CLAUS ,  PIONTEK MICHAEL ,  WEYDEMANN ULRIKE ,  GELLISSEN GERD

IPC: C12N15/09 ,  C07K14/815 ,  C12N15/16 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865

Abstract: A process for the recombinant production of proteins in yeast comprises transforming the yeast with an expression cassette which comprises the following structural elements encoded:L-A-P-GENwhere L is a leader sequence of an animal peptide neurohormone, A is an adaptor producing an alpha-helix structure, P is a processing signal and GEN is a structural gene for the required protein.

公开(公告)号：ZA971107B

公开(公告)日：1998-08-11

申请号：ZA971107

申请日：1997-02-11

Applicant: BASF AG

Inventor： RADITSCH MARTIN ,  FRIEDRICH THOMAS ,  BOLLSCHWEILER CLAUS ,  SCHMIDT MARTIN ,  HOEFFKEN HANS WOLFGANG ,  SCHWEDEN JUERGEN ,  RUEBSAMEN KLAUS

IPC: C12N15/09 ,  A61K31/00 ,  A61K38/00 ,  A61K38/46 ,  A61P7/00 ,  A61P7/04 ,  C07K14/47 ,  C12N9/74 ,  C12N15/00 ,  C12N15/57 ,  C12R1/91 ,  C07K ,  A61K ,  C07H

Abstract: PCT No. PCT/EP97/00612 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Feb. 11, 1997 PCT Pub. No. WO97/29198 PCT Pub. Date Aug. 14, 1997The invention concerns thrombin muteins which have the following differences in their sequences as compared with natural thrombin: (a) the exchange of a Gly after Ala, the Gly being in the sequence environment Tyr-Gly-Phe and having position 558 in natural human thrombin (SEQ ID No. 14); (b) at least one exchange or deletion of the following radicals: (b1) His, located in the sequence environment Ala-His-Cys and having position 363 in natural human thrombin (SEQ ID No. 14); (b2) Asp, located in the sequence environment Arg-Asp-Ile and having position 419 in natural human thrombin (SEQ ID No. 14); (b3) Ser, located in the sequence environment Asp-Ser-Gly and having position 525 in natural human thrombin (SEQ ID No. 14). The invention further concerns the use of these muteins as antidotes.

公开(公告)号：HRP940968A2

公开(公告)日：1997-08-31

申请号：HRP940968

申请日：1994-12-01

Applicant: BASF AG

Inventor： SCHWEDEN JUERGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：HUT74390A

公开(公告)日：1996-12-30

申请号：HU9601471

申请日：1994-11-25

Applicant: BASF AG

Inventor： ECKES PETER ,  HORNBERGER WILFRIED ,  SCHWEDEN JUERGEN ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：HU9601471D0

公开(公告)日：1996-07-29

申请号：HU9601471

申请日：1994-11-25

Applicant: BASF AG

Inventor： ECKES PETER ,  HORNBERGER WILFRIED ,  SCHWEDEN JUERGEN ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：FI962299A

公开(公告)日：1996-05-31

申请号：FI962299

申请日：1996-05-31

Applicant: BASF AG

Inventor： SCHWEDEN JUERGEN ,  ECKES PETER ,  HORNBERGER WILFRIED ,  SUBKOWSKI THOMAS

IPC: A61K38/00 ,  A61K47/48 ,  A61P7/02 ,  C07K

Abstract: PCT No. PCT/EP94/03901 Sec. 371 Date May 31, 1996 Sec. 102(e) Date May 31, 1996 PCT Filed Nov. 25, 1994 PCT Pub. No. WO95/15183 PCT Pub. Date Jun. 8, 1995The invention relates to novel hirudin conjugates formed from a hirudin and one or more lipophilic compounds, where the lipophilic compound has an octanol/water partition coefficient of more than 1.8 and is chemically linked to the hirudin, to the preparation thereof and to the use thereof.

公开(公告)号：CA2169567A1

公开(公告)日：1995-03-16

申请号：CA2169567

申请日：1994-09-01

Applicant: BASF AG ,  RHEIN BIOTECH PROZ & PROD GMBH

Inventor： SCHWEDEN JUERGEN ,  BOLLSCHWEILER CLAUS ,  PIONTEK MICHAEL ,  WEYDEMANN ULRIKE ,  JANOWICZ ZBIGNIEW A ,  STRASSER ALEXANDER W M

IPC: C12N15/09 ,  C07K14/815 ,  C12N1/19 ,  C12N9/34 ,  C12N15/62 ,  C12N15/81 ,  C12P21/02 ,  C12R1/78

Abstract: Described is a method for the recombinant preparation of proteins in Hansenula yeast, the method being characterized in that Hansenula is transformed using an expression cassette which includes encoded in it the following structural elements: L - A - P - GEN in which L is a leader sequence, A is an adaptor generating an alpha-helix structure, P is a processing signal and GEN is a structural gene for the protein required.