公开(公告)号：DE3371783D1

公开(公告)日：1987-07-02

申请号：DE3371783

申请日：1983-03-04

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR

IPC: A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/26

Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula (I) where R is hydrogen, R1 is hydrogen or C1-C3-alkyl, or R and R1 together are methylene, R2 and R3 are identical or different and are each hydrogen or C1-C6-alkyl, and A is hydroxyl, C1-C6-alkoxy, C2-C7-acyloxy, a C2-C7-carbamic acid ester group, C1-C6-alkylsulfonyloxy, C1-C6-alkylmercapto, carboxyl, C2-C7-alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.

公开(公告)号：AT27453T

公开(公告)日：1987-06-15

申请号：AT83102127

申请日：1983-03-04

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR

IPC: A61K31/50 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/26

公开(公告)号：DE3441929A1

公开(公告)日：1986-05-28

申请号：DE3441929

申请日：1984-11-16

Applicant: BASF AG

Inventor： HIMMELE WALTER DR ,  WIERSDORFF WALTER-WIELANT DR ,  THYES MARCO DR

IPC: C07D211/12 ,  C07D211/14 ,  C07D211/16 ,  C07D295/023 ,  C07D211/10

Abstract: Piperidines substituted in the 3- and/or 4-position are prepared by reacting a glutardialdehyde substituted in the 2- and/or 3-position with ammonia or a primary amine and hydrogen at elevated temperature and under superatmospheric pressure in the presence of a hydrogenation catalyst.

公开(公告)号：GR81690B

公开(公告)日：1984-12-12

申请号：GR830173392

申请日：1983-12-29

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：DE3260540D1

公开(公告)日：1984-09-13

申请号：DE3260540

申请日：1982-06-16

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR ,  LENKE DIETER DR ,  KOENIG HORST DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：CS227692B2

公开(公告)日：1984-05-14

申请号：CS471082

申请日：1982-06-24

Applicant: BASF AG

Inventor： ROSSY PHILIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  GRIES JOSEF DR ,  LEHMANN HANS D DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：DE3022177A1

公开(公告)日：1982-01-07

申请号：DE3022177

申请日：1980-06-13

Applicant: BASF AG

Inventor： THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LENKE DIETER PROF DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: -pyridazinone derivs. (I) are new. X is O or S; R1 is H or 1-3C alkyl; and R2 is 1-8C alkyl (opt. substd. by 1-4 halogen atoms, 1-4C alkoxy (sepd. from X by at least 2 C-atoms), 3-8C cycloalkyl (opt. carrying 1 or 2 1-3C alkyl gps.) or phenyl (opt. in turn carrying 1-3 substits. from 1-3C alkyl, 1-3C alkoxy, halogen, CF3 or NO2), 3-8C cycloalkyl (opt. mono- to tetra substd. by 1-4C alkyl), 3-8C alkenyl, 3-8C alkynyl or phenyl (opt. carrying 1-3 substits. from 1-4C alkyl, 1-4C alkoxy, halogen, CF3, CN and NO2). (I) have thrombocyte aggregation inhibiting and hypotensive properties. They can be used as antihypertensive agents and for the prophylaxis and treatment of thrombo-embolid diseases. Results of tests for pharmacological activity are given in the spec.

公开(公告)号：DE2861089D1

公开(公告)日：1981-12-03

申请号：DE2861089

申请日：1978-06-01

Applicant: BASF AG

Inventor： LEBKUECHER ROLF DR ,  THYES MARCO DR ,  KOENIG HORST DR ,  LEHMANN HANS DIETER DR ,  GRIES JOSEF DR ,  LENKE DIETER DR ,  KUNZE JOHANNES DR

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or beta -haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutic agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or alpha -haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thromboembolic disorders.