公开(公告)号：DE2717477A1

公开(公告)日：1978-11-02

申请号：DE2717477

申请日：1977-04-20

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  HOFFMANN WERNER DR ,  MUELLER NORBERT DR

IPC: C07D333/38 ,  C07D333/40

Abstract: Prepn. of thiophen carboxylic acids of formula (I) is effected by reaction of a 3-ketothiphan carboxylic acid (II) with a sulphonic acid: R4. SO2Y (III) to give a 3-sulphato deriv. then reacting the product with an alkali metal polysulphide. The resulting cpd. is treated with a sulphuric acid chloride or bromide or with Cl2 to give modified polysulphide which is finally treated with ahalogen and water. In the formula R is CO2R3 or H; R2 is H whe R' is -CO2R3; or R' is -CO2R3 when R' is H; R3 is H or an aliphatic group; X is halo; R4 is an aliphatic or aromatic group; Y is halo, the group OR3 or a group -O3S.R4. Provides simple, more economic process for prodn. of (I) which is intermediate for thiophen-saccharin sweetening agents. A typical cpd. methyl-3-chlorosulphonylthiophen-4-carboxylate, was prepd. by the 4-stage process from methyl 3-hydroxy-dihydrothiophen-4-carboxylate.

公开(公告)号：DE3302442A1

公开(公告)日：1984-07-26

申请号：DE3302442

申请日：1983-01-26

Applicant: BASF AG

Inventor： THYES MARCO DR ,  ROSSY PHILLIP A DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR MED ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/14

公开(公告)号：DE3302021A1

公开(公告)日：1984-07-26

申请号：DE3302021

申请日：1983-01-22

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：DE3305866A1

公开(公告)日：1984-08-23

申请号：DE3305866

申请日：1983-02-19

Applicant: BASF AG

Inventor： ACKER ROLF-DIETER DR ,  ROSSY PHILLIP A DR ,  WUERZER BRUNO DR

IPC: A01N47/36 ,  C07D333/38

公开(公告)号：DE3235370A1

公开(公告)日：1984-04-26

申请号：DE3235370

申请日：1982-09-24

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  GRIES JOSEF DR ,  LEHMANN HANS-DIETER PROF DR

IPC: C07D237/26 ,  A61K31/50

Abstract: Compounds of the formula in which R and X have the meaning given in the description, and their preparation are described. The novel substances are suitable for controlling diseases.

公开(公告)号：DE3328286A1

公开(公告)日：1984-02-09

申请号：DE3328286

申请日：1983-08-05

Applicant: BASF AG

Inventor： THYES MARCO DR ,  ROSSY PHILLIP A DR ,  KOENIG HORST DR

IPC: C07C233/00 ,  C07C233/12 ,  C07C255/59 ,  C07C103/42 ,  C07C103/737 ,  C07C121/80

Abstract: Novel anilides of the formula in which R denotes a halogen atom and R denotes a hydrogen atom, an alkyl radical having 1 to 3 C atoms or a cycloalkyl radical having 3 to 6 C atoms in the ring, a process for their preparation and a process for their conversion into corresponding anilides, which carry a 3-cyano-2-methylpropionyl radical in the para-position to the amide group. These nitriles are intermediates for the preparation of pharmacologically active 4,5-dihydro-3(2H)-pyridazinones.

公开(公告)号：AT34741T

公开(公告)日：1988-06-15

申请号：AT84100381

申请日：1984-01-16

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

公开(公告)号：DE3535170A1

公开(公告)日：1987-04-16

申请号：DE3535170

申请日：1985-10-02

Applicant: BASF AG

Inventor： GEISS KARL-HEINZ DR ,  THYES MARCO DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  TRAUT MARTIN DR ,  GRIES JOSEF DR MED ,  ROSSY PHILLIP A DR

IPC: C07D401/04 ,  A61K31/50 ,  A61K31/55 ,  A61P3/02 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  C07D209/34 ,  C07D215/22 ,  C07D223/16 ,  C07D237/00 ,  C07D403/04 ,  C12N9/99 ,  C07D215/12

Abstract: 2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula I where m, n, R, R1, R2 and R3 have the stated meanings, are used for the treatment of cardiac insufficiency.

公开(公告)号：GR76010B

公开(公告)日：1984-08-03

申请号：GR820168151

申请日：1982-05-13

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARKO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST DR ,  GRIES JOSEF ,  LEHMANN HANS DIETER DR ,  DIETERLENKE DR

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：DE3471655D1

公开(公告)日：1988-07-07

申请号：DE3471655

申请日：1984-01-16

Applicant: BASF AG

Inventor： ROSSY PHILLIP A DR ,  THYES MARCO DR ,  FRANKE ALBRECHT DR ,  KOENIG HORST PROF DR ,  LEHMANN HANS DIETER PROF DR ,  GRIES JOSEF DR ,  FRIEDRICH LUDWIG DR ,  LENKE DIETER PROF DR

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.