公开(公告)号：CA2237019C

公开(公告)日：2006-05-16

申请号：CA2237019

申请日：1997-09-22

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL ,  BELLAMY DAVID JR ,  PRINCE PAUL R ,  PEKKARINEN MICHAEL O

IPC: B01D69/02 ,  A61K35/14 ,  A61M1/26 ,  A61M1/34 ,  B01D39/16 ,  B01D61/14 ,  B01D61/22 ,  B01D63/16 ,  B01D65/08 ,  B01D69/00

Abstract: A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles (104) and (108) which are differently sized or shaped and in which a first type of red cell particle (104) may be deformable at a relatively lower force and/or faster rate than a second type of white cell particle (108). A filter membrane (100) is provided having pores (102) with substantially precisely dimensioned pore sizes, with the pores (102) being dimensioned to allow passage of the first type of particle (104) without distortion or only minimal distortion and passage of the second type of particle (108) only with substantial distortion. Because the filter membrane (100) has precisely dimensioned pores (102), with spacing between the pores (102) being maintained despite the smaller interval between the pores (102), the porosity of the membrane (100) may be relatively much greater, allowing faster filtration rates while reducing shear exposure time and consequently reducing particle damage. Various methods for preventing clogging of the membrane (100) are also disclosed.

公开(公告)号：BR0212833A

公开(公告)日：2004-10-13

申请号：BR0212833

申请日：2002-09-25

Applicant: BAXTER INT

Inventor： BRYNJELSEN SEAN ,  STERNBERG SHMUEL ,  DUNHAM ANDREW J ,  DOTY MARK J ,  KIPP JAMES E ,  JAYSWAL NAILESH ,  NARAYANAN KRISHNASWAMY

IPC: A61K9/14 ,  A61K9/19 ,  A61K9/51 ,  A61K31/496 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase having the poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

公开(公告)号：CA2416828A1

公开(公告)日：2002-01-31

申请号：CA2416828

申请日：2001-07-18

Applicant: BAXTER INT

Inventor： BREILLATT JULIAN P JR ,  STERNBERG SHMUEL

IPC: A61M1/02 ,  A61M1/22 ,  A61M1/36 ,  B01D39/14 ,  B01D39/16 ,  B01D61/18 ,  B01D63/08 ,  B01D65/00 ,  B01D69/12 ,  B01D29/00 ,  B01D61/00

Abstract: A filter for removing leukocytes from blood comprises a filter media (20) enclosed in a housing (30). The filter media (20) includes a main filter region (MF) comprising a porous membrane structure extending between first a nd second skin surfaces. The porous membrane structure is formed by intersectin g cells having a range of diameters. The cells adjacent to the first skin surface have diameters generally smaller than the diameters of the cells adjacent to the second skin surface. The first skin surface includes an open area defined by pores which are formed by the intersection of cells with the first skin surface. The majority of the open area is defined by pores having a diameter of between about 12 microns and 28 microns.

公开(公告)号：CA2398247A1

公开(公告)日：2001-08-02

申请号：CA2398247

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： BOGGS DANIEL R ,  BREILLATT JULIAN ,  SANDFORD CRAIG ,  KHARE ATUL ,  STERNBERG SHMUEL ,  WOO LECON

IPC: A61L2/00 ,  A61L2/10 ,  A61M1/02 ,  A61M1/36 ,  A61L2/02

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposu re to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid fl ow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation sourc e (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven b y a roller mechanism (38) in the direction of the fluid flow. As the fluid flo ws through thebelt chamber (22), the flexible vanes (36) provide a squeegee-lik e mechanism to move the fluid through the belt chamber (22) in discrete packet s (40) defined by a pair of vanes (36). As the packets of fluid move through t he belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

公开(公告)号：AU2041401A

公开(公告)日：2001-06-06

申请号：AU2041401

申请日：2000-11-02

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL

IPC: B01D67/00 ,  B01D69/02 ,  B01D69/08 ,  B29C67/20

公开(公告)号：AU1455101A

公开(公告)日：2001-06-06

申请号：AU1455101

申请日：2000-11-02

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL

IPC: E04B1/74 ,  C09K5/06 ,  F28D20/02

公开(公告)号：DE69417549T2

公开(公告)日：1999-11-25

申请号：DE69417549

申请日：1994-12-20

Applicant: BAXTER INT

Inventor： STERNBERG SHMUEL ,  LYNN DANIEL

IPC: A61M1/34 ,  A61K35/14 ,  A61K35/18 ,  A61M1/02 ,  A61M1/36 ,  B01D29/01 ,  B01D35/02 ,  B01D39/08 ,  B01D39/16 ,  B01D39/18 ,  B01D39/20 ,  B01D25/00 ,  B01D29/50 ,  B01D35/00 ,  B01D35/30

Abstract: A method correlates average fiber diameter with performance for a complex filtration media comprising a matrix of fibers having a fibrillated component with a diameter so small (e.g., less than 0.01 microns), that cannot be physically measured with accuracy. The method manufactures a selected matrix, derives the number average diameter of the fibers according to prescribed steps, some of which do not require actual physical measurements, and observes a performance characteristic. The method repeats the foregoing steps for different matrixes, yielding different number average diameters. The method expresses change in the selected performance characteristic as a function of change in number average diameter of the matrices.

公开(公告)号：CA2461349C

公开(公告)日：2011-11-29

申请号：CA2461349

申请日：2002-09-25

Applicant: BAXTER INT

Inventor： BRYNJELSEN SEAN ,  STERNBERG SHMUEL ,  DUNHAM ANDREW J ,  DOTY MARK J ,  KIPP JAMES E ,  JAYSWAL NAILESH ,  NARAYANAN KRISHNASWAMY

IPC: A61K9/14 ,  A61K9/51 ,  A61K9/19 ,  A61K31/496 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

公开(公告)号：AT460185T

公开(公告)日：2010-03-15

申请号：AT01912673

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： WOO LECON ,  BOGGS DANIEL ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61M1/02 ,  A61M1/36

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous thin fluid flow arrangement that exhibits radiation dose uniformity for fluids having high optical densities. Radiation dose uniformity is achieved in part through a "carrying" mechanism that moves or carries the fluid, thereby eliminating a channel flow velocity profile where flow volumes near the channel walls run the risk of overexposure to the radiation due to very large residence times within the channel. The device comprises a relatively flat belt chamber (22) connected to a fluid flow through an inlet (24) and an outlet (26) on the belt chamber (22). The belt chamber (22) has a top surface (28) and a bottom surface (30). A radiation permeable plate (32) is disposed adjacent the top surface (28) of the belt chamber (22) and is in contact with the belt chamber (22). A radiation source (42) is provided adjacent to the plate (32) adjacent to a side opposite the belt chamber (22). A belt (34) having a plurality of flexible vanes (36) is disposed adjacent the bottom surface (30) of the belt chamber (22) such that the vanes (36) make contact with the belt chamber (22). The belt is driven by a roller mechanism (38) in the direction of the fluid flow. As the fluid flows through the belt chamber (22), the flexible vanes (36) provide a squeegee-like mechanism to move the fluid through the belt chamber (22) in discrete packets (40) defined by a pair of vanes (36). As the packets of fluid move through the belt chamber, they are exposed to sterilizing radiation passing through the plate (32).

公开(公告)号：AT454170T

公开(公告)日：2010-01-15

申请号：AT01905092

申请日：2001-01-26

Applicant: BAXTER INT

Inventor： WOO LECON ,  BOGGS DANIEL ,  STERNBERG SHMUEL ,  SANDFORD CRAIG ,  KHARE ATUL ,  BREILLATT JULIAN

IPC: A61L2/10 ,  A61L2/00 ,  A61L2/02 ,  A61M1/02 ,  A61M1/36

Abstract: A device and method for inactivating pathogens in therapeutic fluids with sterilizing radiation in a continuous flow arrangement while exhibiting radiation dose uniformity and narrow residence time distribution of the fluid within the device. The device (10) comprises a radiation permeable cylindrical tube (12) having a concentric cylindrical rotor (14) disposed therein, thereby providing a thin gap (16) therebetween. A top plate (18) having a fluid outlet (26) and a bottom plate (20) having a fluid inlet (24) seal the cylindrical tube (12). The inlet (24) and outlet (26) are both in fluid communication with the thin gap (16). A rotor shaft (36) is diposed axially through the cylindrical rotor (14) and is connected to a motor (30). A pump provides fluid flow through the device (10). A radiation source provides sterilizing radiation to the fluid through the cylindrical tube (12). As the fluid flows, the motor (30) drives the rotor (14) to impart Taylor vortices to the fluid flow, which exchanges the fluid closer to the cylindrical tube (12) with the fluid closer to the rotor (14).