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41.发明专利
公开(公告)号：CA2914732A1
公开(公告)日：2014-12-11
申请号：CA2914732
申请日：2014-06-06
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , UNIV NORTHWESTERN
Inventor： HAI TON THAT , GREEN JOHN-BRUCE DEVAULT , FULGHUM TIMOTHY MICHAEL , MESSERSMITH PHILLIP BYRON , SILEIKA TADAS STANISLOVAS
IPC: A61L27/00 , G01N33/543 , G01N33/551
Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.
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公开(公告)号：SG184305A1
公开(公告)日：2012-11-29
申请号：SG2012071858
申请日：2011-04-08
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： BUI TUAN , HAI TON THAT , NORDHAUS MARK , SANDERS PAUL , JIANG CONG , LAMB DAVID , YARDIMCI OZLEM
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公开(公告)号：AU2011240879A1
公开(公告)日：2012-10-25
申请号：AU2011240879
申请日：2011-04-08
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： BUI TUAN , HAI TON THAT , NORDHAUS MARK , SANDERS PAUL , JIANG CONG , LAMB DAVID , YARDIMCI OZLEM
Abstract: A method for immobilizing dyes and antimicrobial agents on a polymeric cover or housing for a medical device is disclosed and described. The surface may be that of a catheter, a connector, a drug vial spike, a bag spike, a prosthetic device, an endoscope, a surface of an infusion pump, a key pad, a touch screen or a handle. The surfaces may also be one or more of those associated with a infusion of a medicament or dialysis treatment, such as peritoneal dialysis or hemodialysis, where it is important that the working surface for the dialysis fluid be sterile. These surfaces include connectors for peritoneal dialysis sets or for hemodialysis sets, bag spikes, dialysis catheters, and so forth. A method for determining whether a surface has been sterilized, and a dye useful in so indicating, is also disclosed.
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公开(公告)号：MX2011001887A
公开(公告)日：2011-04-04
申请号：MX2011001887
申请日：2009-08-21
Applicant: BAXTER INT
Inventor： HAI TON THAT , SANDERS PAUL , JIANG CONG , BROWN LARRY R , YANG GUOHAN , MELNICK BENNETT , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY
Abstract: La presente invención se refiere a derivados poliméricos, los cuales pueden ser conjugados a un medicamento conteniendo amino para mejorar sus propiedades in vivo. El derivado polimérico puede ser liberado subsecuentemente para producir el medicamento en su forma natural. Se describen métodos para preparar y usar estos derivados poliméricos y conjugados de medicamento.
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公开(公告)号：MX2010000809A
公开(公告)日：2010-04-07
申请号：MX2010000809
申请日：2008-07-18
Applicant: BAXTER INT
Inventor： HAI TON THAT , NORDHAUS MARK A , KRONGAUZ VADIM V , LURVEY KENT L
IPC: C07D211/00
Abstract: Se describe un m?todo para inmovilizar colorantes y agentes antimicrobianos sobre una superficie porosa. La superficie puede ser la de un dispositivo m?dico, tal como un cat?ter, un conector, una punta de frasco de f?rmaco, una punta de bolsa, un dispositivo prot?sico, un endoscopio, y superficies de una bomba de infusi?n. Las superficies tambi?n pueden ser una o m?s de aquellas asociadas con un tratamiento de di?lisis, tal como di?lisis peritoneal o hemodi?lisis, en donde es importante esa superficie de trabajo para que el fluido de di?lisis sea est?ril. Estas superficies incluyen conectores para grupos de di?lisis peritoneal o para grupos de hemodi?lisis, puntas de bolsa, cat?teres de di?lisis, y as? sucesivamente. Tambi?n se describe un m?todo para determinar si una superficie ha sido esterilizada, y un colorante ?til para la indicaci?n.
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Patent Agency Ranking
公开(公告)号：AU2009282747A1
公开(公告)日：2010-02-25
申请号：AU2009282747
申请日：2009-08-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： YANG GUOHAN , HAI TON THAT , MELNICK BENNETT , SAUNDERS PAUL , JIANG CONG , QUINN CATHERINE , LI JIE , AMBROISE AROUNAGUIRY , BROWN LARRY R
Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
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公开(公告)号：BRPI0519712A2
公开(公告)日：2009-03-10
申请号：BRPI0519712
申请日：2005-12-15
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： KIPP JAMES E , HAI TON THAT , MELNICK BENNETT P
IPC: C08G65/326 , C08G65/334 , C08L71/02
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公开(公告)号：DE60227189D1
公开(公告)日：2008-07-31
申请号：DE60227189
申请日：2002-10-01
Applicant: BAXTER INT
Inventor： KAROOR SUJATHA , DONOVAN BRIAN , HAI TON THAT , KATADA MARI , LU LUIS , MARTIS LEO , MORTI STAVROULA , MUJAIS SALIM , SANDERS PAUL , SOLTYS PAUL , TANDON RAHUL
IPC: A61M1/16 , A61M1/36 , A61M1/28 , A61M1/34 , B01D15/00 , B01J20/02 , B01J20/06 , B01J20/20 , B01J20/22 , B01J39/10 , B01J41/10
Abstract: The invention provides a device (32) for removing uremic toxins in a dialysis procedure comprising a body having an inlet (42) and an outlet (44) and defining an interior. The interior includes a layer comprising urease, a layer comprising zirconium oxide, a layer comprising zirconium phosphate, and a layer comprising carbon. The device is constructed and arranged so that a fluid entering the device contacts the zirconium phosphate layer before contacting the urease layer and before contacting the zirconium oxide layer.
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公开(公告)号：CA2658133A1
公开(公告)日：2008-01-24
申请号：CA2658133
申请日：2007-07-20
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： LAL BIRENDRA K , SANDFORD CRAIG L , LING MICHAEL TUNG-KIUNG , HOERLE WILLIAM S , KRONGAUZ VADIM V , CAWTHON DUSTIN C , KHANNA ASHOK K , PAULEY ROBIN G , YEH ROSA H , SUH KENNETH GLEN , NORDHAUS MARK A , LURVEY KENT L , SAVITSKI ALEXANDER , KIRICHKOW NICKLAUS J , WOO LECON L , HAI TON THAT , YANG HSINJIN E , KRISHNAMOORTHY SIVARAMAKRISHNAN , CLARKE ROBERT A , STERNBERG SHMUEL
IPC: A61M39/16
Abstract: A medical device, such as a vascular access device, is disclosed for prov iding access to a medical fluid flow path for the introduction or withdrawal of medical fluids to and from the flow path. The access device includes an indicator for providing a visual indication when the access device has been exposed to an antiseptic agent.
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公开(公告)号：CA2591554A1
公开(公告)日：2006-08-03
申请号：CA2591554
申请日：2005-12-15
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： HAI TON THAT , KIPP JAMES E , MELNICK BENNETT P
IPC: C08G65/326 , C08G65/334 , C08L71/02
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