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    Método para la soldadura láser de una unidad de prueba desechable
    43.
    发明专利
    Método para la soldadura láser de una unidad de prueba desechable 未知

    公开(公告)号：ES2656698T3

    公开(公告)日：2018-02-28

    申请号：ES14802875

    申请日：2014-11-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： BABIC BRANISLAV ,  HORN CARINA

    IPC: B29C65/16 ,  B01L3/00 ,  B81C3/00

    Abstract: Un método para soldar por láser una unidad de prueba desechable (10) que comprende a) proporcionar de manera apilada un elemento de base (14), un elemento de cubierta (16) y opcionalmente un elemento intermedio (22), en el que uno de dichos elementos es un elemento absorbente configurado para absorber radiación de un rayo láser y al menos uno de dichos elementos es un elemento transparente que es permeable para la radiación láser, b) dirigir un rayo láser en un área de soldadura (12) a través de al menos un elemento transparente y contra el elemento absorbente, c) fusionar el elemento transparente y el absorbente para formar una unidad de prueba (10) configurada para recibir un fluido corporal, d) proporcionar uno de dichos elementos (14,16,22) en la etapa a) con un recubrimiento (20; 26) que cubre la zona de soldadura (12) al menos en parte y absorbe y/o dispersa la radiación láser al menos en parte, que se caracterizada en que dicho revestimiento (20; 26) está en forma de una capa química que está adaptada para reaccionar con un analito en el fluido corporal cuando se realiza una prueba.

    HIGH LOAD ENZYME IMMOBILISATION BY CROSSLINKING
    45.
    发明专利
    HIGH LOAD ENZYME IMMOBILISATION BY CROSSLINKING 未知

    公开(公告)号：CA2943558A1

    公开(公告)日：2015-10-08

    申请号：CA2943558

    申请日：2015-03-27

    Applicant: HOFFMANN LA ROCHE

    Inventor： HORN CARINA ,  GAWENDA SUSANNE

    IPC: C12N9/96 ,  C12N9/04 ,  C12N11/06 ,  G01N33/66

    Abstract: The present invention relates to a method for cross-linking polypeptide molecules, comprising the step of combining a cross-linking agent and polypeptide molecules in solution under conditions suitable for a cross-linking reaction to occur and to a preparation comprising cross-linked polypeptide molecules obtainable by said method. The present invention further relates to cross-linked polypeptide molecules, wherein said polypeptide molecules are cross-linked by essentially unbranched cross-linking groups comprising at least 40 contiguous atoms. Moreover, the present invention relates to a test chemistry matrix comprising a redox cofactor, an agent capable of eliciting a change in at least one measurable property of an indicator reagent in the presence of redox equivalents, and an indicator reagent, wherein said chemistry matrix further comprises a preparation of cross-linked polypeptide molecules obtainable by the method according to the present invention and/or cross-linked polypeptide molecules according tothe present invention, as well as to a diagnostic test element comprising said test chemistry matrix. The present invention further relates to a preparation of cross-linked polypeptide molecules obtainable by the method according the present invention and/or cross-linked polypeptide molecules according to the present invention for use in the diagnosis of disease and for use in diagnosis of diabetes, as well as to a method for producing a test chemistry matrix.

    METHOD AND SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID
    48.
    发明专利
    METHOD AND SYSTEM FOR DETECTING AN ANALYTE IN A BODY FLUID 未知

    公开(公告)号：CA2910360A1

    公开(公告)日：2014-12-18

    申请号：CA2910360

    申请日：2014-02-24

    Applicant: HOFFMANN LA ROCHE

    Inventor： BAUER-ESPINDOLA KLAUS ANDREAS ,  HORN CARINA ,  MARQUANT MICHAEL ,  NORTMEYER CHRISTINE ,  UNKRIG VOLKER

    IPC: G01N21/84 ,  G01N21/64 ,  G01N27/02 ,  G01N27/327

    Abstract: A method for detecting at least one analyte in a body fluid (112) is disclosed. The method comprises the following steps: a) performing an optical measurement, wherein at least one test chemical (120) is contacted with the body fluid (112), wherein the test chemical (120) is an optical test chemical (120) and is adapted to perform at least one detection reaction in the presence of the analyte, wherein at least one optically detectable property of at least one of the body fluid (112) and the test chemical (120) is changed due to the detection reaction, wherein at least one optical measurement value is generated; b) performing at least one impedance measurement, wherein at least two impedance measurement electrodes (130) are used, wherein at least one alternating electrical signal is applied to the body fluid (112) via the impedance measurement electrodes (130) and wherein at least one answer signal is recorded, wherein at least one impedance measurement value is generated; c) performing at least one evaluation step, wherein, in the evaluation step, at least one evaluation algorithm is used, wherein the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid (112).

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