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    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES
    41.
    发明专利
    METHOD FOR EVALUATING MEDICAL MEASUREMENT CURVES 未知

    公开(公告)号：CA2896152C

    公开(公告)日：2018-07-24

    申请号：CA2896152

    申请日：2013-12-19

    Applicant: HOFFMANN LA ROCHE

    Inventor： AIGNER SIMON ,  CHEMNITIUS GABRIELE ,  HORN CARINA ,  LIMBURG BERND ,  OTTENSTEIN TIMO ,  PETRICH WOLFGANG ,  PLUM MARKUS ,  RINGEMANN CHRISTIAN ,  SERR MARKUS

    IPC: G01N21/77 ,  G01N21/27 ,  G01N21/84

    Abstract: A method for detecting an analyte in a sample of a body fluid comprising the steps of: a) providing an optical measurement curve, which contains a plurality of measurement values recorded by monitoring a time development of a measurement value indicating a progress of a detection reaction of a test substance and the sample of a body fluid, wherein the detection reaction is known to be influenced by a set of state variables; b) providing a set of at least two different evaluation rules being adapted to derive a characteristic value from the optical measurement curve, thereby deriving a set of characteristic values X={Xi} i=1...N from the optical measurement curve; c) performing a multivariate analysis of the first and the second characteristic value by using a predetermined multivariate evaluation algorithm adapted to derive a result from at least two variables, wherein the at least one first and second characteristic value are used as the at least two variables, thereby deriving an estimate value for at least one target variable Y of the state variables; d) determining a concentration of the analyte by using the variable Y.

    METHOD FOR DETECTING AN INTERFERENT CONTRIBUTION IN A BIOSENSOR
    42.
    发明专利
    METHOD FOR DETECTING AN INTERFERENT CONTRIBUTION IN A BIOSENSOR 未知

    公开(公告)号：CA3014852A1

    公开(公告)日：2017-09-21

    申请号：CA3014852

    申请日：2017-03-14

    Applicant: HOFFMANN LA ROCHE

    Inventor： RINGEMANN CHRISTIAN ,  WIEDER HERBERT

    IPC: G01N27/327 ,  C12Q1/00

    Abstract: A method for detecting an interferent contribution in a biosensor is disclosed. Herein, the biosensor has a first electrode (112), a second electrode, and a third electrode (114), wherein the first electrode (112) and the second electrode are covered by a membrane, wherein the first electrode (112) further includes an enzyme or wherein the first electrode (112) is covered by an enzyme layer. Further, the first electrode (112), the second electrode, and the third electrode (114) are connected via a potentiostat, wherein, in a normal operational mode, via the potentiostat an electrical potential difference is applied between the first electrode (112) and the second electrode in a manner that the first electrode (112) allows for oxidative processes and the third electrode (114) allows for reductive processes. The method comprises the steps of: a) switching from the normal operational mode to an interferent detection mode, wherein, in the interferent detection mode, the electrical potential difference between the first electrode (112) and the second electrode is altered for a limited period of time in a manner that the third electrode (114) allows for oxidative processes; b) measuring a current- voltage characteristic (110) of the third electrode (114); and c) determining the interferent contribution in the biosensor by evaluating the current-voltage characteristic (110) of the third electrode (114). The method allows deducting the presence and, preferably, the amount of the interferent in an unambiguous way and is, generally, applicable in case of more than one kind of interferent. Neither additional working electrodes nor supplementary circuit components are required. The method is implementable within sensor electronics architectures of standard biosensors and, thus, applicable in already existing biosensor systems.

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