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    Laser exposure of photosensitive masks for dna microarray fabrication
    42.
    发明专利
    Laser exposure of photosensitive masks for dna microarray fabrication 未知

    公开(公告)号：AU2003303106A8

    公开(公告)日：2004-08-13

    申请号：AU2003303106

    申请日：2003-11-26

    Applicant: INTEL CORP

    Inventor： YAMAKAWA MINEO ,  BERLIN ANDREW ,  RAO VALLURI

    IPC: B01J19/00 ,  B05D3/00 ,  C12M1/34 ,  C12Q1/68 ,  G03F1/00 ,  G03F7/20

    Abstract: A method and apparatus for forming a polymer array on a substrate suitable for synthesizing polymer sequences. This includes forming an array, each location of the array having at least one strand end, forming photosensitive protection on the strand ends, and selectively scanning and modulating at least one energy beam to expose a pattern on the photosensitive protection. In some embodiments, the method further includes removing a protective group from selected strand ends based on the exposed pattern. The method then includes adding a predetermined one or more polymeric subunits to the deprotected strand ends. In some embodiments the photosensitive protection includes a layer of photoresist to cover the strand ends. Some embodiments use an ultra-violet laser.

    47.
    发明专利
    未知

    公开(公告)号：DE60330809D1

    公开(公告)日：2010-02-11

    申请号：DE60330809

    申请日：2003-10-07

    Applicant: INTEL CORP

    Inventor： CHAN SELENA ,  BERLIN ANDREW ,  KWON SUNGHOON ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO

    IPC: G01J3/44 ,  B01D67/00 ,  B01D71/02 ,  C12Q1/68 ,  G01N21/65

    Abstract: The methods, systems 400 and apparatus disclosed herein concern metal 150 impregnated porous substrates 110, 210. Certain embodiments of the invention concern methods for producing metal-coated porous silicon substrates 110, 210 that exhibit greatly improved uniformity and depth of penetration of metal 150 deposition. The increased uniformity and depth allow improved and more reproducible Raman detection of analytes. In exemplary embodiments of the invention, the methods may comprise oxidation of porous silicon 110, immersion in a metal salt solution 130, drying and thermal decomposition of the metal salt 140 to form a metal deposit 150. In other exemplary embodiments of the invention, the methods may comprise microfluidic impregnation of porous silicon substrates 210 with one or more metal salt solutions 130. Other embodiments of the invention concern apparatus and/or systems 400 for Raman detection of analytes, comprising metal-coated porous silicon substrates 110, 210 prepared by the disclosed methods.

    48.
    发明专利
    未知

    公开(公告)号：DE112004002522T5

    公开(公告)日：2008-07-03

    申请号：DE112004002522

    申请日：2004-12-28

    Applicant: INTEL CORP

    Inventor： SU XING ,  ZHANG JINGWU ,  SUN LEI ,  BERLIN ANDREW

    IPC: G01N21/65 ,  G01N33/543

    Abstract: Composite organic-inorganic nanoclusters (COINs) are provided that produce surface-enhanced Raman signals (SERS) when excited by a laser. The nanoclusters include metal particles and a Raman-active organic compound. The metal required for achieving a suitable SERS signal is inherent in the nanocluster and a wide variety of Raman-active organic compounds and combinations thereof can be incorporated into the nanocluster. In addition, polymeric microspheres containing the nanoclusters and methods of making them are also provided. The nanoclusters and microspheres can be used, for example, in assays for multiplex detection of biological molecules.

    Methods to increase nucleotide signals by Raman scattering
    49.
    发明专利
    Methods to increase nucleotide signals by Raman scattering 未知

    公开(公告)号：AU2003223269B2

    公开(公告)日：2008-01-17

    申请号：AU2003223269

    申请日：2003-03-11

    Applicant: INTEL CORP

    Inventor： SU XING ,  KOO TAE-WOONG ,  SUNDARARAJAN NARAYAN ,  YAMAKAWA MINEO ,  BERLIN ANDREW ,  CHAN SELENA

    IPC: G01N21/65 ,  B01L3/00 ,  C12M1/00 ,  C12Q1/68 ,  G01N33/543

    Abstract: The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid 13 . Exonuclease 15 treatment of the labeled nucleic acid 13 results in the release of labeled nucleotides 16, 130, which are detected by Raman spectroscopy. In alternative embodiments of the invention, nucleotides 16, 130 released from a nucleic acid 13 by exonuclease 15 treatment are covalently cross-linked to silver or gold nanoparticles 140 and detected by surface enhanced Raman spectroscopy (SERS), surface enhanced resonance Raman spectroscopy (SERFS) and/or coherent anti-Stokes Raman spectroscopy (CARS). Other embodiments of the invention concern apparatus 10, 100, 210 for nucleic acid sequencing.

    50.
    发明专利
    未知

    公开(公告)号：DE60309903T2

    公开(公告)日：2007-10-18

    申请号：DE60309903

    申请日：2003-09-24

    Applicant: INTEL CORP

    Inventor： SU XING ,  CHAN SELENA ,  KOO TAE-WOONG ,  YAMAKAWA MINEO ,  BERLIN ANDREW

    IPC: G01N33/543 ,  C12Q1/68 ,  G01B7/34

    Abstract: The present methods and apparatus concern the detection and/or identification of target analytes using probe molecules. In various embodiments of the invention, the probes or analytes are attached to one or more cantilevers. Binding of a probe to an analyte results in deflection of the cantilever, detected by a detection unit. A counterbalancing force may be applied to restore the cantilever to its original position. The counterbalancing force may be magnetic, electrical or radiative. The detection unit and the mechanism generating the counterbalancing force may be operably coupled to an information processing and control unit, such as a computer. The computer may regulate a feedback loop that maintains the cantilever in a fixed position by balancing the deflecting force and the counterbalancing force. The concentration of analytes in a sample may be determined from the magnitude of the counterbalancing force required to maintain the cantilever in a fixed position.

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