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    Fructosyl dipeptide or salt thereof
    41.
    发明专利
    Fructosyl dipeptide or salt thereof 有权
    果糖或其盐

    公开(公告)号：JP2005170930A

    公开(公告)日：2005-06-30

    申请号：JP2004325500

    申请日：2004-11-09

    Applicant: Kao Corp ,  花王株式会社

    Inventor： SUGIYAMA MITSURU ,  SAKASAI MITSUYOSHI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/64 ,  A61Q9/04 ,  A61Q19/00 ,  A61Q19/08 ,  C07K9/00 ,  A61K7/00 ,  A61K7/155 ,  A61K7/48

    Abstract: PROBLEM TO BE SOLVED: To provide a skin care preparation for external use having efficacy for preventing or improving the aging of skin such as the development of wrinkles and for inhibiting hair growth.
    SOLUTION: There is provided fructosyl dipeptide represented by general formula (1): Fru-A-B-R (1) or a salt thereof, and also provided a skin care preparation for external use, a hair growth inhibitor and a wrinkle-preventing or improving agent, each containing the same. In general formula (1), Fru denotes a fructosyl residue; A denotes a valine residue or an isoleucine residue; B denotes a tyrosine residue, a phenylalanine residue, a valine residue or an isoleucine residue; and R denotes a hydroxy group or a methoxy group.
    COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种具有用于预防或改善皮肤老化的效果的外用护肤品，例如皱纹的发展和抑制毛发生长。 提供由通式（1）表示的果糖基二肽：Fru-ABR（1）或其盐，并且还提供用于外用的护肤制剂，毛发生长抑制剂和抗皱纹或 改善剂，每种含量相同。 通式（1）中，Fru表示果糖基残基; A表示缬氨酸残基或异亮氨酸残基; B表示酪氨酸残基，苯丙氨酸残基，缬氨酸残基或异亮氨酸残基; R表示羟基或甲氧基。 版权所有（C）2005，JPO＆NCIPI

    PRODUCTION OF THISTLE EXTRACT
    44.
    发明专利
    PRODUCTION OF THISTLE EXTRACT 失效

    公开(公告)号：JP2000256123A

    公开(公告)日：2000-09-19

    申请号：JP5553299

    申请日：1999-03-03

    Applicant: KAO CORP

    Inventor： KANAZAWA SATOSHI ,  NISHIZAWA YOSHINORI ,  ICHII YUJI ,  MORI SHINOBU ,  SATO MAYUMI

    IPC: A61K8/96 ,  A61K8/00 ,  A61K8/02 ,  A61K8/97 ,  A61K36/28 ,  A61Q19/00 ,  A61Q19/10 ,  A61K7/00 ,  A61K7/48 ,  A61K7/50 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To obtain the subject extract which is useful in compositions of preparation for external use for skin or compositions of bath preparation by contacting an extract solvent solution from a thistle group plant with a synthetic adsorbent and removing the adsorbate from the above adsorbent to effect decoloring the extract while holding its lipolytic activity. SOLUTION: This extract is obtained by contacting an extract solvent solution such as ethanol solution from a thistle group plant such as Cirsium nipponicum var incomptum with a synthetic adsorbent, preferably a styrene- divinylbenzene-based synthetic adsorbent, acrylic ester-based synthetic adsorbent or methacrylic acid ester-based synthetic adsorbent, and then removing the adsorbate from the above adsorbent. The amount of the above adsorbent to be used is preferably 0.1-6.0 wt. times based on the solid amount in the solution to be treated. An adsorbent treatment operation is performed preferably under ordinary pressure to 50 atomospheric pressure and at room temperature to 40 deg.C temperature, and in the case of a batch method, the treatment time is preferably 1-24 h.

    HAIR-RESTORING AND GROWING MATERIAL
    46.
    发明专利
    HAIR-RESTORING AND GROWING MATERIAL 失效

    公开(公告)号：JPH1192339A

    公开(公告)日：1999-04-06

    申请号：JP25503097

    申请日：1997-09-19

    Applicant: KAO CORP

    Inventor： OUCHI ATSUSHI ,  HOTTA MITSUYUKI ,  KANAZAWA SATOSHI ,  NISHIZAWA YOSHINORI ,  HORI KIMIHIKO ,  NISHIJIMA AYUMI

    IPC: A61K8/00 ,  A61K8/97 ,  A61K36/00 ,  A61K36/18 ,  A61P17/00 ,  A61P43/00 ,  A61Q5/00 ,  A61Q7/00 ,  A61K7/06

    Abstract: PROBLEM TO BE SOLVED: To obtain a hair-restoring and growing material, e.g. a lotion and a hair tonic, which shows excellent hair-growing activity against various alopecia in spite of symptoms and individual differences and is safe to the living body by formulating extracts from Echinacea angustifolia, Echinacea purpurea and/or Tropaeolum majus as active ingredients. SOLUTION: This material is obtained by formulating extracts from (A) Echinacea angustifolia, Echinacea purpurea and/or (B) Tropaeolum majus preferably in amounts of 0.01-1 wt.% based on the whole weight in the dry weight. On the above-stated extracts, roots or whole grasses of Echinacea angustifolia or Echinacea purpurea are used as the component A and leaves of Tropaeolum majus are used as the component B. These ground pieces are extracted with a solvent, e.g. an aqueous solution of propylene glycol and the like, preferably at an ordinary temperature of 3-70 deg.C to obtain the material. It is preferable that this hair-restoring and growing agent is used as a solution such as a shampoo and a rinse.

    PRODUCTION OF 1-(BETA-HYDROXYETHYL)-2,5-DIAMINOBENZENE OR ITS SALT
    47.
    发明专利
    PRODUCTION OF 1-(BETA-HYDROXYETHYL)-2,5-DIAMINOBENZENE OR ITS SALT 失效

    公开(公告)号：JPH1112239A

    公开(公告)日：1999-01-19

    申请号：JP16571897

    申请日：1997-06-23

    Applicant: KAO CORP

    Inventor： SAITO YOSHINORI ,  KIYOMINE AKIRA ,  NISHIZAWA YOSHINORI ,  FUJIKURA YOSHIAKI

    IPC: C07C205/26 ,  C07B61/00 ,  C07C213/02 ,  C07C215/68

    Abstract: PROBLEM TO BE SOLVED: To produce the subject compound useful as a raw material for dyes, pigments, polymers and agrochemicals by using a 2-halogenophenylacetic acid as a starting raw material. SOLUTION: A 1-(β-hydroxyethyl)-2-halogeno-5-nitrobenzene represented by formula I (X is a halogen) is reacted with benzylamine to provide 1-(β- hydroxyethyl)-2-benzylamino-5-nitrobenzene represented by formula II, which is then reduced to afford the objective compound represented by formula III. The compound represented by formula I is obtained by esterifying a 2- halogenophenylacetic acid represented by formula IV and then nitrating the resultant compound or nitrating the 2-halogenophenylacetic acid and then esterifying the prepared compound, affording a 2-halogeno-5-nitrophenylacetic acid ester and then reducing the resultant ester. The objective compound can be produced in high selectivity and high yield according to a method for passing the inexpensive and readily available compound represented by formula IV as a raw material through the compound represented by formula I which is a new compound.

    NOVEL STEROID COMPOUND AND INTERLEUKIN-1 PRODUCTION INHIBITOR CONTAINING THE SAME
    48.
    发明专利
    NOVEL STEROID COMPOUND AND INTERLEUKIN-1 PRODUCTION INHIBITOR CONTAINING THE SAME 失效

    公开(公告)号：JPH10291997A

    公开(公告)日：1998-11-04

    申请号：JP10303797

    申请日：1997-04-21

    Applicant: KAO CORP

    Inventor： KUSUOKU HIROSHI ,  NISHIZAWA YOSHINORI ,  FUJIKURA YOSHIAKI ,  ICHIKAWA YOSHIAKI ,  IMOKAWA GENJI

    IPC: A61K31/575 ,  A61P17/00 ,  A61P37/08 ,  A61P43/00 ,  C07J9/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a subject novel compound that contains a specific steroid compound, shows an excellent transdermal absorption, stability and safety and is useful as a strongly effective interleukin 4 production inhibitor and as an antiallergic agent that is effective for prevention and treatment of atopic dermatitis. SOLUTION: This is a novel steroid compound represented by formula I (Me is methyl) and is useful as a strongly effective interleukin 4 production inhibitor excellent in transdermal absorption, stability and safety and as an antiallergic agent the has preventive and therapeutic effect on the atopic dermatitis. This steroid compound is obtained by extracting a kind of fungus, Elfvinga (Elfvinga applanta) that has been used as a Chinese medicine. This compound also can be prepared by oxidizing ergosterol of formula II with a selenium dioxide in the presence of methanol to form an isomer followed by treatment of the product with an acid catalyst in methanol to invert the methoxy group in the 3-position thereby giving the objective compound.

    SKIN LOTION
    49.
    发明专利
    SKIN LOTION 失效

    公开(公告)号：JPH10194919A

    公开(公告)日：1998-07-28

    申请号：JP1777897

    申请日：1997-01-16

    Applicant: KAO CORP

    Inventor： HORI TAKASHI ,  NISHIZAWA YOSHINORI ,  MASUDA MITSUHARU ,  KAWAKAMI KYOKO

    IPC: A61K8/30 ,  A61K8/00 ,  A61K8/41 ,  A61K8/49 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00 ,  A61K7/48

    Abstract: PROBLEM TO BE SOLVED: To obtain a skin lotion, excellent in skin-aging-preventing effect and improving effect of skin trouble caused by abnormality of keratinization and having good safety and stability by combinedly using a specific chromone derivative with specific amine derivatives. SOLUTION: This skin lotion is obtained by formulating (A) one or two or more kinds of compound selected from a chromone derivative of formula I (R is a 1-15C straight-chain or branched chain alkyl; R is H, OH or a lower alkoxy) with (B) an amine derivative of formula II (R is a 1-40C alkyl or a 1-40C cycloalkyl; R is H or an alkyl) or its acid additive salt. 2-(1- Ethylpenthyl)-7-methoxychromone, etc., is preferably used as the component A. 1-(2-Hydroxyehylamino)-3-isostearyloxy-2-propanol, etc., is preferably used as the component B. The components A and B are each preferably formulated in a ratio of 0.01-50wt.% and 0.005-10wt.% based on total amount of skin lotion.

    CELL ADHESION SUPPRESSANT
    50.
    发明专利
    CELL ADHESION SUPPRESSANT 失效

    公开(公告)号：JPH1067656A

    公开(公告)日：1998-03-10

    申请号：JP32827196

    申请日：1996-12-09

    Applicant: KAO CORP

    Inventor： MURASE TAKATOSHI ,  HASE TADASHI ,  SHIBUYA YUSUKE ,  NISHIZAWA YOSHINORI ,  TOKIMITSU ICHIROU

    IPC: C07D493/04 ,  A61K31/365 ,  A61K36/00 ,  A61P9/10 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00 ,  A61K35/78

    Abstract: PROBLEM TO BE SOLVED: To prepare a medicine, having low cytotoxicity, excellent suppressing actions on cell adhesion and useful as a suppressant, etc., for cancer metastasis by using specific lignans as an active ingredient. SOLUTION: This cell adhesion suppressant comprises lignans represented by the formula (R to R are each H, hydroxyl, an alkyl, a hydroxyalkyl or an alkoxy) as an active ingredient. Furthermore, the lignans are preferably obtained by carrying out the extraction treatment of, e.g. a leaf part of Thujopsis dolabrata Sieb. et Zucc. of the family Cupressaceae with water, an organic solvent such as toluene, an aqueous alcohol, etc., usually at 3-70 deg.C and the lignans are preferably blended in an amount of 1-70wt.% in the pharmaceutical preparation. The dose thereof for an adult is preferably 0.1-2,000mg at a time and daily and perorally administered in one to several portions.

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