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公开(公告)号：JP2004307365A
公开(公告)日：2004-11-04
申请号：JP2003100477
申请日：2003-04-03
Inventor： MORI SHINOBU , SATO MAYUMI , YOSHIZUKA NAONOBU , HASHIZUME KOJIRO , KUSUOKU HIROSHI
Abstract: PROBLEM TO BE SOLVED: To obtain a lipolysis promoter and a slimming agent accelerating hydrolysis of accumulated fat tissues and exhibiting slimming actions. SOLUTION: The lipolysis promoter and slimming agent comprise Nelumbo nucifera Gaerth or an extract thereof as an active ingredient. The lipolysis promoter and slimming agent are useful for suppressing or preventing obesity, ameliorating obese constitution and reducing the weight of local or whole-body fat tissues. COPYRIGHT: (C)2005,JPO&NCIPI
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公开(公告)号：JP2003292427A
公开(公告)日：2003-10-15
申请号：JP2002098900
申请日：2002-04-01
Inventor： SASAJIMA MICHIYO , YOSHIZUKA NAONOBU
IPC: A61K8/00 , A61K8/97 , A61K36/18 , A61K36/23 , A61K36/25 , A61K36/28 , A61K36/48 , A61K36/53 , A61K36/71 , A61K36/73 , A61K36/75 , A61K36/899 , A61P17/00 , A61Q15/00 , A61K7/32 , A61K35/78
Abstract: PROBLEM TO BE SOLVED: To provide a deodorant agent or an apolipoprotein D-secretion inhibitor useful as a highly safe cosmetic or the like having excellent deodorant activities because of sustainably inhibiting the formation of unpleasant body odor. SOLUTION: The deodorant agent or the apolipoprotein D-secretion inhibitor comprises a plant selected from Phellodendri cortex, Phellodendron amurens Ruprecht, Gallae rhois, Rhus javanica L, seeds of Oryza sativa L., Haematoxylon campechianum L., Arnica montana L., Foeniculi fructus, Isodonis herba, Isodon japonicus Hara, Coptidis rhizome, Asiasari radix, Zanthoxyli fructus, Astragalus sinicus, Hedera helix, Cinnamomi cortex, Melissa officinalis, Aesculus hippocastanum, Uncaria gambir Roxburgh, Upharis rhizome, Centella asiatica and Sanguisorba officinalis L, or an extract thereof. COPYRIGHT: (C)2004,JPO
Abstract translation: 要解决的问题：提供一种除臭剂或载脂蛋白D-分泌抑制剂，其可用作高度安全的化妆品等，因为可持续地抑制不愉快的身体气味的形成，具有优异的除臭活性。 解毒剂：除臭剂或载脂蛋白D-分泌抑制剂包括选自Phellodendri cortex，Phellodendron amurens Ruprecht，Gallae rhois，Rhus javanica L，Oryza sativa L.，Haematoxylon campechianum L.，Arnica montana L. ，茯苓，异黄ba，异根us，黄连，黄芪，黄芪，黑檀，樟脑皮，Melissa officinalis，七叶树七叶树，乌头草甘草，乌龙属根茎，积雪草和Sanguisorba officinalis L，或 其提取物。 版权所有（C）2004，JPO
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公开(公告)号：JP2000281519A
公开(公告)日：2000-10-10
申请号：JP8168799
申请日：1999-03-25
Applicant: KAO CORP
Inventor： NOMURA TOMOKO , YOSHIZUKA NAONOBU , OUCHI ATSUSHI
IPC: A61K8/00 , A61K8/42 , A61K8/68 , A61K31/00 , A61K31/7032 , A61P17/00 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/00
Abstract: PROBLEM TO BE SOLVED: To obtain the subject hair grower capable of exhibiting hair growing, hair fostering and depilation preventing effect in an application of minor amount, exhibiting high safety for a long time by including a specific glycolipid. SOLUTION: This hair grower includes sphingoglycolipid (preferably lactosylceramide). The hair grower preferably includes 0.001-20 wt.% of the sphingoglycolipid. For example, a prescription for the hair growing agent comprises 1.0% of the lactosylceramide, 2.5% of α-monoisostearyl glyceryl ether, 15.5% of propylene glycol, 35.5% of ethanol, 12.0% of isopropanol and 33.5% of ion exchanged water. The hair grower having excellent hair growing, hair fostering and depilation preventing effect and expectable of high safety for a long time, useful for cosmetics and medicines is provided.
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公开(公告)号：JPH11276191A
公开(公告)日：1999-10-12
申请号：JP8839398
申请日：1998-04-01
Inventor： MATSUO NOBORU , WAKIZAKA ETSUJI , NOMURA TOMOKO , TAKIZAWA MINORU , YOSHIZUKA NAONOBU
IPC: C12P19/44
Abstract: PROBLEM TO BE SOLVED: To simply carry out a reaction with a sphingoglycolipid synthase in two or more stages in one pot by reacting a saccharide acceptor with two or more saccharide donors in the presence of a lipid vesicle containing two or more kinds of sphingoglycolipid synthases.
SOLUTION: A sphingolipid or a sphingoglycolipid which is a saccharide acceptor is reacted with two or more kinds of sacccharide donors in the presence of a lipid vesicle containing two or more kinds of sphingoglycolipid synthases. The reaction with the sphingoglycolipid synthases in two or more stages is made to progress without carrying out isolating operations in the course thereof to afford a sphingoglycolipid containing two or more saccharides bound to the saccharide acceptor.
COPYRIGHT: (C)1999,JPOAbstract translation: 要解决的问题：在含有两种或多种鞘糖脂合成酶的脂质囊泡的存在下，通过使糖受体与两种或多种糖供体反应，在一盆中简单地进行与鞘糖脂合成酶的两步或多步反应。 解决方案：在含有两种或更多种鞘糖脂合成酶的脂质囊泡的存在下，作为糖受体的鞘脂或鞘糖脂与两种或更多种sacccharide供体反应。 在两个或多个阶段中与鞘糖脂合成酶的反应进行而不进行其过程中的分离操作，以提供含有与糖受体结合的两种或更多种糖的鞘糖脂。
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公开(公告)号：JPH09227592A
公开(公告)日：1997-09-02
申请号：JP6892597
申请日：1997-03-07
Applicant: KAO CORP
Inventor： OSAWA TOSHIAKI , YOSHIZUKA NAONOBU , YOSHIMURA MASAAKI , YOSHIDA EISAKU
IPC: C12P21/02 , A61K38/00 , A61P35/00 , A61P37/04 , C07K7/06 , C07K14/47 , C07K14/52 , C07K14/53 , C07K14/535 , C12R1/91
Abstract: PROBLEM TO BE SOLVED: To obtain a new peptide of macrophage chemotaxis factor, having a specific amino acid sequence, originated from human peripheral blood lymphocyte, exhibiting a macrophage chemotaxis activity, and useful as a reagent for researching delayed-type hypersensitivity, an antitumor agent, etc. SOLUTION: This new peptide (salt) has an amino acid sequence of the formula (X is Glu, Gln), has a macrophage chemotaxis activity and is useful as a reagent for researching delayed-type hypersensitivity, as medicines such as an antitumor agent. The new peptide is obtained by fusing a human peripheral blood lymphocyte stimulated with phytohemagglutinin with human acute t-cell leukemic cell strain CEM-11 by an emetine-actinomycin method, incubating the obtained human T-cell hybridoma in a culture medium in the presence of 5% CO2 at 37 deg.C, centrifuging the culture solution, collecting the supernatant and subsequently purifying the supernatant by an ultrafiltration method, a column chromatography, etc.
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Patent Agency Ranking
公开(公告)号：JPH0975086A
公开(公告)日：1997-03-25
申请号：JP23664995
申请日：1995-09-14
Applicant: KAO CORP
Inventor： IMANAKA TADAYUKI , YOSHIZUKA NAONOBU , KIMURA TAKETSUNE , TAKAGI MASAHIRO , EZAKI SATOSHI
IPC: C12N1/21 , A61K39/395 , C07H21/04 , C12N15/09 , C12R1/125
Abstract: PROBLEM TO BE SOLVED: To obtain a new vector holding an antibody gene and a control gene having a reporter gene, enabling the expression gene of the antibody gene to join with an antigen to express the reporter gene, and facilitating the production of a monoclonal antibody. SOLUTION: This new antigen-specific antibody-expressing vector is a vector holding the antibody gene and the control gene having a reporter gene, and is integrated so that the antibody produced by joining of the expression of the antibody gene and an antigen to express the reporter gene. Since antigen- specific antibody-producing cells can selectively be collected by an extremely simple operation, the production of the monoclonal antibody is extremely facilitated. The new expression vector is obtained by integrating a penicillinase operon gene comprising a penicillinase gene, a repressor region and an antirepressor region into Bacillus subtilis pTB522, and further inserting the antirepressor region into the antibody gene.
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公开(公告)号：JPH04128215A
公开(公告)日：1992-04-28
申请号：JP24806590
申请日：1990-09-18
Applicant: KAO CORP
Inventor： OUCHI ATSUSHI , YOSHIMURA MASAAKI , KIDENA HIDEFUMI , HOTTA MITSUYUKI , YOSHIZUKA NAONOBU
Abstract: PURPOSE:To obtain a hair growth promoter, containing a centipede or an extract thereof, capable of promoting hair growth regardless of symptoms or physical constitution and effective against various alopecias. CONSTITUTION:The objective substance is obtained by containing 0.0001-50wt.% centipede or an extract thereof and further normally an extracting solvent such as a lower alcohol, water, a surfactant, etc., suitably blending a blood circulation promoter, an immunosuppressive agent, a metabolic promoter, a vitaminic agent, an antiandrogenic hormone, a cell growth factor, etc., normally used in a hair growth agent and preparing a hair growth promoter. The aforementioned promoter can be prepared into a form such as liquid, paste or emulsion. The centipede which is an arthropod can be used regardless of a difference in area of production, growth period, tissual organs, etc., and normally in the form of powder. The extract of the centipede is obtained by extraction thereof with a solvent such as water, butanol or hexane according to a conventional method.
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公开(公告)号：JPH03228678A
公开(公告)日：1991-10-09
申请号：JP20794689
申请日：1989-08-14
Applicant: KAO CORP
Inventor： OSAWA TOSHIAKI , SAKAMOTO SUSUMU , YOSHIZUKA NAONOBU
IPC: C12N15/09 , A61K38/00 , A61P35/00 , C07K5/10 , C07K7/06 , C07K14/00 , C07K14/52 , C12N15/19 , C12P21/02
Abstract: PURPOSE:To obtain a precursor of human macrophage chemotactic factor in high purity and large quantities by preparing a now gene from mRNA derived from a human peripheral blood lymphocyte, human T lymphocyte hybridoma and/or human T lymphocyte based established cell. CONSTITUTION:A normal human peripheral blood lymphocyte, human T human lymphocyte established cell and/or cloning strain is cultured and a cell capable of synthesizing a protein having an amino sequence having a human macrophage chemotactic factor(MCF) or partial structure thereof is cultured therefrom and a fraction containing mRNA is separated from total RNA fraction obtained by grinding the resultant cell and extracting from the ground cell. Then cDNA prepared using the above-mentioned mRNA as template and successively using a reverse transcription enzyme, reverse transcriptase and ribonuclease and DNA synthetic enzyme is integrated into a vector and the resultant recombinant is introduced into a host to provide cDNA library. The cDNA coding a human MCF precursor protein is cloned from the above-mentioned cDNA library by a plaque hybridization method to provide the cloned DNA capable of coding a human MCF precursor protein and having a base sequence expressed by the formula.
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公开(公告)号：JPH02215721A
公开(公告)日：1990-08-28
申请号：JP3602189
申请日：1989-02-17
Applicant: KAO CORP
Inventor： OTSUJI KAZUYA , YOSHIZUKA NAONOBU , SUZUKI HIROYUKI , HONDA YASUKI , INAOKA KAZU , SUGIMURA YORIO
IPC: A61K36/18 , A61K31/715 , A61P35/00 , C08B37/00
Abstract: PURPOSE:To obtain an anticancer agent containing specific acidic heteropolysaccharides induced from a plant of the genus Polianthes L. as an active ingredient and extremely reduced in side effects. CONSTITUTION:The aimed anticancer agent containing arabinose, mannose, galactose, glucuronic acid and xylose as ingredients, having binding manner and constituent ratio expressed by the formula and containing acidic heteropolysaccharides having 1X10 -2X10 molecular weight as an active ingredient. The above-mentioned polysaccharides are obtained by culturing a part of organ or tissue of a plant (e.g. Polianthes tuberosa L.) belonging to the genus Polianthes used as an explant in a culture medium containing a plant hormone to induce callus and subjecting the callus to culture; preferably shake culture in a culture medium (preferably liquid medium) containing a plant hormone at 20-30 deg.C for 15-30 day and collecting from the cultured product.
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公开(公告)号：JPS632534B2
公开(公告)日：1988-01-19
申请号：JP12565183
申请日：1983-07-11
Applicant: KAO CORP
Inventor： YOSHIZUKA NAONOBU , TAKEUCHI EIJIRO , IMOKAWA GENJI
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