公开(公告)号：AU2016366694C1

公开(公告)日：2021-03-25

申请号：AU2016366694

申请日：2016-12-11

Applicant: PTC THERAPEUTICS INC

Inventor： BABU SURESH ,  BHATTACHARYYA ANURADHA ,  HWANG SEONGWOO ,  JANI MINAKSHI ,  MOON YOUNG-CHOON ,  SYDORENKO NADIYA

IPC: C07D405/12 ,  A61K31/506 ,  A61P25/00

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：HUE039026T2

公开(公告)日：2018-12-28

申请号：HUE16170630

申请日：2004-04-09

Applicant: PTC THERAPEUTICS INC

Inventor： KARP GARY ,  HWANG SEONGWOO ,  CHEN GUANGMING ,  ALMSTEAD NEIL ,  MOON YOUNG-CHOON

IPC: A61K31/4245 ,  A61P35/00 ,  C07D271/06 ,  C07D271/12 ,  C07D413/04 ,  C07D413/10

公开(公告)号：CA3119019A1

公开(公告)日：2017-06-15

申请号：CA3119019

申请日：2016-12-11

Applicant: PTC THERAPEUTICS INC

Inventor： BABU SURESH ,  BHATTACHARYYA ANURADHA ,  HWANG SEONGWOO ,  JANI MINAKSHI ,  MOON YOUNG-CHOON ,  SYDORENKO NADIYA

IPC: C07D401/14 ,  A61K31/501 ,  A61P25/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10

Abstract: The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

公开(公告)号：NO338270B1

公开(公告)日：2016-08-08

申请号：NO20064519

申请日：2006-10-05

Applicant: PTC THERAPEUTICS INC

Inventor： HWANG SEONGWOO ,  MOON YOUNG-CHOON ,  CAO LIANGXIAN ,  TAMILARASU NADARAJAN ,  QL HONGYAN ,  CHOI SOONGYU ,  LENNOX WILLIAM JOSEPH ,  CORSON DONALD THOMAS

IPC: C07D471/04 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  A61K31/724 ,  A61P35/00

公开(公告)号：SI1618098T1

公开(公告)日：2015-04-30

申请号：SI200432222

申请日：2004-04-09

Applicant: PTC THERAPEUTICS INC

Inventor： KARP GARY MITCHELL ,  HWANG SEONGWOO ,  CHEN GUANGMING ,  ALMSTEAD NEIL GREGORY ,  MOON YOUNG-CHOON

IPC: C07D271/00 ,  A61K31/00 ,  A61K31/4245 ,  A61P35/00 ,  C07D271/06 ,  C07D271/12 ,  C07D413/04 ,  C07D413/10

公开(公告)号：NZ596965A

公开(公告)日：2013-06-28

申请号：NZ59696507

申请日：2007-03-29

Applicant: PTC THERAPEUTICS INC

Inventor： ALMSTEAD NEIL G ,  CHEN GUANGMING ,  HIRAWAT SAMIT ,  HWANG SEONGWOO ,  KARP GARY M ,  KENNEDY PAUL ,  MILLER LANGDON ,  MOON YOUNG-CHOON ,  REN HONGYU ,  TAKASUGI JAMES J ,  WELCH ELLEN M ,  WILDE RICHARD G

IPC: A61K31/40 ,  A61K31/00 ,  A61K31/41 ,  A61K31/4162 ,  A61K31/44 ,  A61K31/46 ,  A61P1/00 ,  A61P5/00 ,  A61P25/28

Abstract: 596965 Disclosed is the use of a compound having the formula defined herein, or a pharmaceutically acceptable salt, solvate or hydrate thereof, in the treatment of cystic fibrosis, wherein the subject has a nonsense mutation in the codon corresponding to position 414, 493, 1316, 553, 542, 1162,122, 1455, 822, 60, 764, 1291, 849, 434, 88, 1158 or 6542 of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Specific embodiments of the compound include: 3-[S-2-fluoro-phenyl-[1,2,4]oxadiazol-3-yl]-benzoic acid (PTC124).

公开(公告)号：CA2521992C

公开(公告)日：2013-02-05

申请号：CA2521992

申请日：2004-04-09

Applicant: PTC THERAPEUTICS INC

Inventor： KARP GARY MITCHELL ,  HWANG SEONGWOO ,  CHEN GUANGMING ,  ALMSTEAD NEIL GREGORY ,  MOON YOUNG-CHOON

IPC: C07D271/06 ,  A61K31/4245 ,  C07D271/12 ,  C07D413/04 ,  C07D413/10

Abstract: Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

公开(公告)号：MX2008012515A

公开(公告)日：2008-11-19

申请号：MX2008012515

申请日：2007-03-29

Applicant: PTC THERAPEUTICS INC

Inventor： WILDE RICHARD G ,  MOON YOUNG-CHOON ,  KENNEDY PAUL ,  HWANG SEONGWOO ,  CHEN GUANGMING ,  HIRAWAT SAMIT ,  MILLER LANGDON ,  ALMSTEAD NEIL G ,  KARP GARY M ,  REN HONGYU ,  TAKASUGI JEMES J ,  WELCH ELLEN M

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4162 ,  A61K31/44 ,  A61K31/46 ,  A61P1/00 ,  A61P5/00 ,  A61P25/28

Abstract: La presente invención se relaciona con proteínas funcionales codificadas por las secuencias de ácido nucleico que comprenden una mutación sin sentido. La presente invención también se relaciona con métodos para la producción de proteínas funcionales codificadas por secuencias de ácido nucleico que comprenden una mutación sin sentido y el uso de tales proteínas para la prevención, manejo y/o tratamiento de enfermedades asociadas con una o unas mutaciones sin sentido en un gen.

公开(公告)号：MA27802A1

公开(公告)日：2006-03-01

申请号：MA28594

申请日：2005-11-09

Applicant: PTC THERAPEUTICS INC

Inventor： KARP GARY MITCHELL ,  HWANG SEONGWOO ,  CHEN GUANGMING ,  ALMSTEAD NEIL GREGORY

IPC: A61K31/4245 ,  C07D271/06 ,  C07D271/12 ,  C07D413/04 ,  C07D413/10

Abstract: L'invention concerne des composés d'acide benzoïque 1,2,4-oxadiazoIe, des procédés d'utilisation et des compositions pharmaceutiques renfermant un dérivé de l'acide benzoïque 1,2,4-oxadiazole. Parmi les procédés d'utilisation, on peut citer des méthodes de traitement ou de prévention d'une maladie améliorée par la modulation de la fin précoce de la translation ou de la dégradation des ARNm induite par non-sens ou d'amélioration d'un ou plusieurs symptômes associés à celle-ci.

公开(公告)号：CA2559408A1

公开(公告)日：2005-09-29

申请号：CA2559408

申请日：2005-03-15

Applicant: PTC THERAPEUTICS INC

Inventor： MOON YOUNG-CHOON ,  CAO LIANGXIAN ,  CORSON DONALD THOMAS ,  LENNOX WILLIAM JOSEPH ,  HWANG SEONGWOO ,  TAMILARASU NADARAJAN ,  QI HONGYAN ,  CHOI SOONGYU

IPC: A61K31/497 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  A61K31/724 ,  A61P35/00 ,  C07D471/04

Abstract: In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.