公开(公告)号：AU2007299010B2

公开(公告)日：2013-01-31

申请号：AU2007299010

申请日：2007-09-17

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  HUSEN BETTINA ,  KALLIO LILA ,  SCHOEN UWE ,  THOLE HEINRICH-HUBERT ,  KOSKIMIES PASI

IPC: C07J43/00 ,  A61K31/58 ,  A61P5/32 ,  A61P13/00 ,  A61P35/00

Abstract: This invention relates to novel estratrien-triazoles of general formula (I) useful in therapy, especially for use in the treatment and/or prevention of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring the inhibition of a 17&bgr;-hydroxysteroid dehydrogenase (17&bgr;-HSD) such as 17&bgr;-HSD type 1, type 2 or type 3 enzyme.

公开(公告)号：PL207995B1

公开(公告)日：2011-02-28

申请号：PL35477402

申请日：2002-06-27

Applicant: SOLVAY PHARM GMBH

Inventor： SCHOEN UWE ,  MESSINGER JOSEF ,  BRUECKNER REINHARD ,  ZIEGLER DIETER

IPC: C07D471/08 ,  A61K31/435 ,  A61K31/439 ,  A61P9/00 ,  A61P9/06 ,  C07D221/00 ,  C07D471/10

公开(公告)号：PL1976997T3

公开(公告)日：2009-09-30

申请号：PL07712041

申请日：2007-01-16

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  RASCHE HEINZ-HELMER ,  SCHMIDT MICHAEL ,  HAKALA JUHA

IPC: C12P33/08 ,  C07J7/00

公开(公告)号：AT431351T

公开(公告)日：2009-05-15

申请号：AT04804787

申请日：2004-12-13

Applicant: SOLVAY PHARM GMBH

Inventor： HIRVELAE LEENA ,  HUSEN BETTINA ,  KIVINIEMI JOHANNA ,  KOSKIMIES PASI ,  LEHTOVUORI PEKKA ,  MESSINGER JOSEF ,  PENTIKAEINEN OLLI TANELI ,  KALLIO LILA ,  SAARENKETO PAULI ,  THOLE HEINRICH-HUBERT ,  UNKILA MIKKO ,  VAN STEEN BARTHOLOMEUS JOHANNES

IPC: C07D495/04 ,  A61K31/519

公开(公告)号：MX2009002579A

公开(公告)日：2009-03-20

申请号：MX2009002579

申请日：2007-09-17

Applicant: SOLVAY PHARM GMBH

Inventor： KOSKIMIES PASI ,  MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  SCHOEN UWE ,  KALLIO LILA

IPC: C07J43/00 ,  A61K31/58 ,  A61P5/32 ,  A61P13/00 ,  A61P35/00

Abstract: Esta invención se refiere a estratrien-triazoles nuevos de fórmula general (I) útiles en la terapia, especialmente para el uso en el tratamiento y/o la prevención de un trastorno dependiente de hormonas esteroideas, preferiblemente una enfermedad o trastorno dependiente de hormonas esteroideas que requiere la inhibición de una enzima 17ß-hidroxiesteroide deshidrogenasa (17ß-HSD) tal como 17ß-HSD de tipo 1, tipo 2 o tipo 3. (ver fórmula I).

公开(公告)号：ES2314478T3

公开(公告)日：2009-03-16

申请号：ES04804529

申请日：2004-11-11

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  VAN STEEN BARTHOLOMEUS JOHANNES ,  SCHNEIDER GYULA ,  HULSHOF JOHANNES BERNARDUS EVERARDUS

IPC: C07J1/00 ,  A61K31/565

Abstract: Un compuesto de fórmula general I, (Ver fórmula) en la cual (i) X representa: (a) un enlace, (b) -NR 3 -, o (c) -O-; A representa: (a) -CO-, o (b) con la condición de X represente -NR 3 , A representa -SO2-; Y representa: (a) -NR 4 -, (b) -O-, con la condición de que X represente un enlace o -NR 3 -, (c) un enlace, (d) -NH-SO2-, con la condición de que X represente -NR 3 y A represente -CO-, (e) -NH-SO2-NR 4 , con la condición de que X represente -O-, o (f) -NH-NR 4 -, con la condición de que X represente un enlace, o (ii) -X-A-Y- conjuntamente representa -O-; y en donde...

公开(公告)号：HK1117538A1

公开(公告)日：2009-01-16

申请号：HK08108101

申请日：2008-07-23

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  HEINRICH-HUBERT THOLE H ,  HUSEN BETTINA ,  KOSKIMIES PASI ,  PIRKKALA LILA ,  WESKE MICHAEL

IPC: A61K20060101 ,  A61P20060101 ,  C07J20060101

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

公开(公告)号：PT1685150E

公开(公告)日：2008-11-12

申请号：PT04804529

申请日：2004-11-11

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  JOHANSSON NINA ,  KOSKIMIES PASI ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  STEEN BARTHOLOMEUS JOHANNES VAN ,  SCHNEIDER GYULA ,  HULSHOF JOHANNES BERNARDUS EVERARDUS ,  ADAMSKI JERZY

IPC: C07J1/00 ,  A61K31/565

公开(公告)号：NO20076616L

公开(公告)日：2008-02-01

申请号：NO20076616

申请日：2007-12-21

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  WESKE MICHAEL ,  KOSKIMIES PASI ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  PIRKKALA LILA

IPC: C07J41/00

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

公开(公告)号：BRPI0416551A

公开(公告)日：2007-02-27

申请号：BRPI0416551

申请日：2004-11-11

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  STEEN BARTHOLOMEUS JOHANNES VA ,  SCHNEIDER GYULA ,  HULSHOF JOHANNES BERNARDUS EVA ,  KOSKIMIES PASI ,  JOHANSSON NINA ,  ADAMSKI JERZY

IPC: A61K31/565 ,  C07J1/00

Abstract: The present invention relates to novel 3, 15 substituted estrone derivatives which represent inhibitory compounds of the 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1), to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel 3, 15 substituted estrone derivatives, particularly their use in the treatment or prevention of steroid hor­mone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17beta-hydroxysteroid dehydrogenase type I enzymes and/or requiring the lowering of the endogenous 17beta-estradiol concentration. In addition, the present invention relates to the general use of selective 17beta-hydroxysteroid dehydrogenase type 1 inhibitors which possess in addition no or only pure antagonistic binding affinities to the estrogen receptor for the treatment and prevention of benign gynaecological disorders, in particular endometriosis.