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公开(公告)号：CA2686838A1
公开(公告)日：2008-11-20
申请号：CA2686838
申请日：2008-05-09
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , BEAR BRIAN , ZHOU JINGLAN , MILLER MARK , HADIDA RUAH SARA , GROOTENHUIS PETER D J
IPC: C07D401/04 , A61K31/444 , A61P11/00 , A61P37/00 , C07D405/14
Abstract: Compounds of the present invention, and pharmaceutically acceptable compo sitions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") tr ansporters or fragments thereof, including Cystic Fibrosis Transmembrane Con ductance Regulator ("CFTR"). The present invention also relates to methods o f treating CFTR mediated diseases using compounds of the present invention.
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公开(公告)号：CA2869945A1
公开(公告)日：2007-10-18
申请号：CA2869945
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , YANG XIAOQING
IPC: C07D405/12 , A61K31/404 , A61K31/41 , A61K31/4439 , A61K31/454 , C07D209/08 , C07D403/12 , C07D413/12 , G01N33/48
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：AU2007235260A1
公开(公告)日：2007-10-18
申请号：AU2007235260
申请日：2007-04-09
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , MCCARTNEY JASON , ZHOU JINGLAN , GOOR FREDERICK VAN , MILLER MARK T , NUMA MEHDI MICHEL JAMEL , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：CA2856037A1
公开(公告)日：2007-08-02
申请号：CA2856037
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： RUAH SARA S HADIDA , MILLER MARK T , BEAR BRIAN , MCCARTNEY JASON , GROOTENHUIS PETER D J
IPC: C07C237/24 , A61K31/00 , C07C311/46 , C07D207/12 , C07D307/79 , C07D317/60 , C07D319/18 , C07D405/12 , C07D409/12 , C07D413/12 , C07D498/04
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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公开(公告)号：CA2635760A1
公开(公告)日：2007-08-02
申请号：CA2635760
申请日：2006-12-28
Applicant: VERTEX PHARMA
Inventor： MCCARTNEY JASON , RUAH SARA S HADIDA , MILLER MARK T , BEAR BRIAN , GROOTENHUIS PETER D J
IPC: C07D317/68 , A61K31/36 , A61P11/00
Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
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Patent Agency Ranking
公开(公告)号：RU2765714C2
公开(公告)日：2022-02-02
申请号：RU2016150386
申请日：2016-12-21
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTHY JASON , ZHOU JINGLAN
IPC: C07D405/12 , A61K31/443 , A61P11/00
Abstract: Изобретениеотноситсяк фармацевтическойкомпозициидлялечениязаболеваний, опосредуемыхтрансмембраннымрегулятороммуковисцидоза («CFTR»), причемкомпозициясодержитфармацевтическиприемлемыйносительитерапевтическиэффективноеколичествосоединенияформулыТехническийрезультат: полученановаяфармацевтическаякомпозиция, котораяможетбытьиспользованадлялечениязаболеваний, опосредуемыхтрансмембраннымрегулятороммуковисцидоза («CFTR»). 7 табл.
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公开(公告)号：NZ715751A
公开(公告)日：2021-09-24
申请号：NZ71575114
申请日：2014-07-18
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , JOHNSON JAMES , BEAR BRIAN , TERMIN ANDREAS , KRENITSKY PAUL
IPC: C07C311/46 , A61K31/18
Abstract: The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.
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公开(公告)号：CA3039943C
公开(公告)日：2021-07-13
申请号：CA3039943
申请日：2009-02-25
Applicant: VERTEX PHARMA
Inventor： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN
IPC: C07D405/12 , A61K31/495 , A61K31/497 , C07D241/20
Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, which are modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：HUE053448T2
公开(公告)日：2021-06-28
申请号：HUE17152492
申请日：2014-01-29
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , ASGIAN IULIANA , BEAR BRIAN , TERMIN ANDREAS , JOHNSON JAMES
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公开(公告)号：LT3239134T
公开(公告)日：2021-02-25
申请号：LT17152492
申请日：2014-01-29
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA , ANDERSON COREY , ARUMUGAM VIJAYALAKSMI , ASGIAN IULIANA , BEAR BRIAN , TERMIN ANDREAS , JOHNSON JAMES
IPC: C07D213/75 , A61K31/44 , A61K31/4412 , A61P29/00 , C07D401/12 , C07D405/12
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