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    Biological sample analyzer
    46.
    发明公开
    Biological sample analyzer 失效
    Vorrichtung zur分析生物学家Proben。

    公开(公告)号：EP0353591A2

    公开(公告)日：1990-02-07

    申请号：EP89113616.0

    申请日：1989-07-24

    Applicant: ABBOTT LABORATORIES

    Inventor： Defreese, James Douglas ,  Huang, Tung-Ming ,  Holen, James T. ,  Gray, Robert Carlton ,  Bailey, Mark Wallace ,  Donohue, Joseph Patrick ,  Putterman, Caryn Glickson

    IPC: G01N35/02 ,  G01N21/47 ,  G01N33/53

    CPC classification number: G01N33/5302 ,  G01J2001/161 ,  G01J2001/1636 ,  G01N21/253 ,  G01N35/00029 ,  G01N2021/0162 ,  G01N2021/478 ,  G01N2035/00099 ,  G01N2035/00752 ,  G01N2035/1025 ,  G01N2201/0415 ,  G01N2201/069 ,  G01N2201/12761

    Abstract: A semi-automated biological sample analyzer and subsystems are provided to simultaneously perform a plurality of enzyme immuno assays for himan IgE class antibodies specific to a panel of preselected allergens in each of a plurality of biological samples. A carou­sel is provided to position and hold a plurality of reaction cartridges. Each reaction cartridge includes a plurality of isolated test sites formed in a two dimensional array in a solid phase binding layer con­tained within a reaction well which is adapted to con­tain a biological sample to be assayed. The carousel and cartridges contain structures which cooperate to precisely position the cartridges in each of three separate dimensions so that each cartridge is posi­tioned uniformly. An optical reader operating on a principle of diffuse reflectance is provided to read the results of the assays from each test site of each cartridge. Also provided is a subsystem which provides predetermined lot-specific assay calibration data which is useful for normalizing the results of various assays with respect to predetermined common standard values.

    Abstract translation: 提供半自动化生物样品分析仪和子系统，以同时对多个生物样品中的每一个中预先选择的过敏原的一组特异性的himan IgE类抗体进行多次酶免疫测定。 提供转盘以定位和保持多个反应盒。 每个反应盒包括在包含在反应井内的固相结合层中的二维阵列中形成的多个分离的测试位点，其适于含有要测定的生物样品。 圆盘传送带和墨盒包含结构，其配合以将墨盒精确地定位在三个分开的尺寸中的每一个中，使得每个墨盒均匀地定位。 提供以漫反射原理工作的光学阅读器，以从每个盒的每个测试位置读取测定结果。 还提供了一种子系统，其提供预定的特异性测定校准数据，其可用于相对于预定的共同标准值标准化各种测定的结果。

    ANALYZER AND METHOD FOR HIGHLY SENSITIVE DETECTION OF ANALYTES
    47.
    发明公开
    ANALYZER AND METHOD FOR HIGHLY SENSITIVE DETECTION OF ANALYTES 审中-公开
    分析师VERFAHREN ZUR HOCHEMPFINDLICHEN DETEKTION VON ANALYTEN

    公开(公告)号：EP3156799A1

    公开(公告)日：2017-04-19

    申请号：EP16186528.2

    申请日：2007-04-04

    Applicant: Singulex, Inc.

    Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

    IPC: G01N33/53 ,  G01N21/64 ,  G01N33/58 ,  G01N33/68 ,  G01N15/14

    CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

    Abstract: Disclosed is an analyzer for determining the presence, absence or amount of an analyte in a sample, wherein the analyzer comprises: (a) an electromagnetic radiation source (301) that emits electromagnetic radiation that defines an interrogation space comprising a focused spot of a beam from the electromagnetic radiation source (301); (b) a capillary flow cell (313) for passing a sample through the interrogation space; (c) a source of motive force for moving the sample in the capillary flow cell (313); (d) an electromagnetic radiation detector (309) operatively connected to the interrogation space that detects photons emitted from the interrogation space during a plurality of bins; and (e) a processor (310) operatively connected to the detector (309), wherein the processor determines the presence, absence or amount of an analyte in a sample by:
    (i) determining a threshold photon value corresponding to a background signal in the interrogation space, (ii) determining the presence of a photon emitting species comprising or corresponding to the analyte in the interrogation space in each bin of the plurality of bins by identifying bins having a photon value greater than the threshold value, (iii) comparing the number of bins having a photon value greater than the threshold value to a standard curve that is generated using one or more samples of known standard concentrations.

    Abstract translation: 公开了一种用于确定样品中分析物的存在，不存在或数量的分析器，其中所述分析仪包括：（a）电磁辐射源（301），其发射限定询问空间的电磁辐射，所述电磁辐射源包括光束的聚焦点 来自所述电磁辐射源（301）; （b）用于使样品通过询问空间的毛细管流通池（313） （c）用于使毛细管流通池中的样品移动的动力源; （d）可操作地连接到询问空间的电磁辐射检测器（309），其在多个箱中检测从询问空间发射的光子; 和（e）可操作地连接到检测器（309）的处理器（310），其中处理器通过以下步骤来确定样品中分析物的存在，不存在或量：（i）确定对应于背景信号的阈值光子值 询问空间，（ii）通过识别具有大于阈值的光子值的箱，确定在多个箱的每个箱中的询问空间中包含或对应于分析物的光子发射物质的存在，（iii）比较 具有大于阈值的光子值的箱数与使用已知标准浓度的一个或多个样品产生的标准曲线。

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