公开(公告)号：WO1998012964A1

公开(公告)日：1998-04-02

申请号：PCT/US1997017206

申请日：1997-09-25

Applicant: CHO, Zang-Hee ,  BUNNEY, William, E., Jr.

IPC: A61B05/055

CPC classification number: G01R33/385 ,  G01R33/3854

Abstract: The present invention describes a new imaging technique using a mechanically rotating DC gradient coil (112), effectively replacing both the phase encoding and readout gradient pulsings, and reducing the induced noise from these coils. The invention comprises a static magnetic field generator (128) for exciting an inspection object (106) disposed in an inspection space (104) with a magnetic field about the (z-) axis, a magnetic resonance signal measurement device (110) for measuring signals from the inspection object (106), a first gradient magnetic field generator (112) for creating a first (x-) gradient magnetic field in the inspection space (104), wherein the first gradient magnetic field is rotatable about a first (z-) axis, and a second gradient magnetic field generator (130) for creating a second (z-) gradient magnetic field in the inspection space (104), wherein the first (x-) gradient magnetic field and the second (z-) magnetic field are substantially orthogonal.

Abstract translation: 本发明描述了使用机械旋转的DC梯度线圈（112）的新成像技术，其有效地替代了相位编码和读出梯度脉冲，并且减少了来自这些线圈的感应噪声。 本发明包括一个静磁场发生器（128），用于激励位于检查空间（104）中的围绕（z-轴）的磁场的检查对象（106），用于测量的磁共振信号测量装置 来自检查对象（106）的信号，用于在检查空间（104）中产生第一（x-）梯度磁场的第一梯度磁场发生器（112），其中第一梯度磁场围绕第一（z） - ）轴，以及用于在所述检查空间（104）中产生第二（z-）梯度磁场的第二梯度磁场发生器（130），其中所述第一（x-）梯度磁场和所述第二（z-） 磁场基本正交。

公开(公告)号：WO1997048337A1

公开(公告)日：1997-12-24

申请号：PCT/US1997010510

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP.

Inventor： IMARX PHARMACEUTICAL CORP. ,  UNGER, Evan, C. ,  MATSUNAGA, Terry, O. ,  FRITZ, Thomas, A. ,  RAMASWAMI, Varada, Rajan

IPC: A61B05/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

Abstract translation: 提供患者内部区域的图像的方法。 该方法的实施方案涉及向患者施用造影剂，其包含囊泡组合物，所述囊泡组合物在水性载体中包含气体或气体前体和包含脂质，蛋白质或聚合物的囊泡。 使用诸如超声波之类的诊断成像扫描患者，以获得该区域的可见图像。 将造影剂以基本上消除图像中的诊断伪像的速率施用于患者。 该方法对于诊断患者中任何患病组织的存在特别有用。

公开(公告)号：WO1997024064A1

公开(公告)日：1997-07-10

申请号：PCT/US1996020338

申请日：1996-12-27

Applicant: PRINCE, Martin, R.

IPC: A61B05/055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: The present invention is a technique and apparatus for monitoring and detecting the arrival of a contrast agent in a region of interest (e.g., an artery or tissues of interest). In one embodiment, upon detecting a maximum, substantially elevated or elevated concentration of contrast agent in the region of interest, a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention may be employed to facilitate synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement.

Abstract translation: 本发明是用于监测和检测造影剂到感兴趣区域（例如感兴趣的动脉或组织）的技术和装置。 在一个实施方案中，当检测到感兴趣区域中造影剂的最大，基本上升高或升高的浓度时，可以获得磁共振图像数据的预定部分（例如，表示k空间中心的数据） 。 因此，本发明可以用于促进将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。

公开(公告)号：WO1996015717A1

公开(公告)日：1996-05-30

申请号：PCT/IB1995000894

申请日：1995-10-20

Applicant: PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB

Inventor： PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB ,  MEULENBRUGGE, Hendrik, Jan ,  TUITHOF, Hans, Hermanus ,  VAN VAALS, Johannes, Jacobus

IPC: A61B05/055

CPC classification number: A61B6/4417 ,  A61B5/0035 ,  A61B5/0046 ,  A61B5/055 ,  A61B6/107 ,  G01R33/4812

Abstract: The invention relates to a magnetic resonance device (1) for imaging inter alia human organs by way of magnetic resonance. Whe, for example, in neurosurgery interventional techniques are executed in combination with a magnetic resonance device (1), the organs are suitably visualized but the instruments guided to an organ via an opening in the body are not visible or only hardly so. In order to carry out interventional procedures, the patient must be transported between two rooms. Transporting the patient over a long distance between two rooms is objectional because of the risk of motion of the instruments lodged within the body of the patient, as such motion could be fatal to the patient. A solution consists in arranging an X-ray device (20) adjacent the MR device (1), so that the patient need be transported a short distance only. Undesirable mutual influencing of the MR device (1) and the X-ray device (20) is counteracted by shielding the static magnetic field of the MR device and the electromagnetic fields generated by the X-ray device.

Abstract translation: 本发明涉及一种用于通过磁共振对人体器官成像的磁共振装置（1）。 例如，在神经外科介入技术中与磁共振装置（1）组合执行时，器官被适当地可视化，但是通过身体中的开口引导到器官的器械是不可见的或仅仅是不可见的。 为了进行介入手术，患者必须在两间房间之间运送。 在两个房间之间长距离运送病人是异常的，因为仪器在病人身体内移动的风险，因为这种运动可能对患者致命。 解决方案在于布置与MR装置（1）相邻的X射线装置（20），使得患者仅需要短距离运输。 MR装置（1）和X射线装置（20）的不希望的相互影响通过屏蔽MR装置的静磁场和由X射线装置产生的电磁场来抵消。

公开(公告)号：WO1995017850A1

公开(公告)日：1995-07-06

申请号：PCT/IB1994000423

申请日：1994-12-14

Applicant: PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB

Inventor： PHILIPS ELECTRONICS N.V. ,  PHILIPS NORDEN AB ,  FUDERER, Miha

IPC: A61B05/055

CPC classification number: G01R33/56554 ,  G01R33/50 ,  G01R33/5615

Abstract: In a GRASE (Gradient and Spin-Echo) magnetic resonance method, most profiles in k-space with a certain Ky value are measured with different magnetic field read gradient polarity and at different time intervals from the excitation RF-pulse. The two resulting sets of measurements, with positive and negative read gradient polarity, respectively, are used to correct read gradient polarity dependent phase errors, in order to obtain reconstructed images in which the effects of these phase errors are greatly reduced. In an improved version the measurements are used to reconstruct images with a predictable T2 weighting.

Abstract translation: 在GRASE（梯度和自旋回波）磁共振方法中，具有一定Ky值的k空间中的大多数轮廓是用不同的磁场读取梯度极性和与激励RF脉冲不同的时间间隔来测量的。 分别使用正和负读取梯度极性的两组测量结果来校正读取梯度极性相关的相位误差，以便获得这些相位误差的影响大大降低的重构图像。 在改进的版本中，测量用于以可预测的T2加权重建图像。

公开(公告)号：WO1995014429A1

公开(公告)日：1995-06-01

申请号：PCT/US1994013770

申请日：1994-11-22

Applicant: BULLWINKEL, Paul

IPC: A61B05/055

CPC classification number: G02C7/14 ,  A61B3/111 ,  A61B3/113 ,  A61B5/055 ,  H04N13/344 ,  H04N13/346

Abstract: The instant invention is a display system that provides visual stimuli to a patient (12) who is undergoing diagnostic treatment within a magnetic resonance imaging apparatus (10). The system utilizes a pair of lightweight fiber optic video glasses (34) having a hollow chamber (72, 74) wherein a prism (94) with mirrors splits a visual image supplied through a fiber optic cable (32) connected to an LCD projector (28, 48). The projector (28, 48) uses a series of lenses for coupling a signal received from a video interface (24, 44) which monitors the use of an external VCR or television (26, 40) utilizing a standard NTSC format video signal. The visual image is projected onto the inner surface of reflective lenses (84, 84') which allows the patient to view the image as well as see through the lens providing a HUD type display.

Abstract translation: 本发明是一种向在磁共振成像设备（10）内进行诊断治疗的患者（12）提供视觉刺激的显示系统。 该系统使用一对具有中空室（72,74）的轻质光纤视频眼镜（34），其中具有镜子的棱镜（94）将通过连接到LCD投影仪的光纤电缆（32）提供的视觉图像分开 28，48）。 投影仪（28,48）使用一系列透镜来耦合从视频接口（24,44）接收的信号，该视频接口（24,44）利用标准NTSC格式视频信号监视外部VCR或电视（26,40）的使用。 将视觉图像投影到反射透镜（84,84'）的内表面上，其允许患者观看图像，以及透过提供HUD型显示器的透镜。

公开(公告)号：WO1995010228A1

公开(公告)日：1995-04-20

申请号：PCT/EP1994003325

申请日：1994-10-08

Applicant: DR. FISCHER AG ,  FISCHER, Gerhard ,  WARNKE, Ulrich

Inventor： DR. FISCHER AG

IPC: A61B05/055

CPC classification number: A61B5/415 ,  A61B5/05 ,  A61B5/7239 ,  A61N2/02 ,  G01R33/12

Abstract: In a device for determining the effect of pulsed primary magnetic fields on an organism, the individual signals of a measurement sensor, for example a measurement coil, are deviated from the organism through a sampling circuit, are supplied to an evaluation circuit containing a memory and are summed by a memory. The summation signal serves as output signal of the evaluation circuit. This device may be used for example for controlling and monitoring exposure to magnetic fields in the medical field.

Abstract translation: 本发明涉及一种设备，用于确定对生物体，其特征在于，测量传感器的单独的信号，例如一个测量线圈，通过由生物体的消隐导出并供给到一个具有存储评估电路和由存储器来求和脉冲初级磁场的效果。 总和信号作为评价电路的输出信号。 该装置可被用于例如控制和在医疗领域的磁场暴露监测。

公开(公告)号：WO1995005118A1

公开(公告)日：1995-02-23

申请号：PCT/US1994008459

申请日：1994-07-28

Applicant: CONCAT LTD.

Inventor： CONCAT LTD. ,  WINCHELL, Harry, S. ,  KLEIN, Joseph, Y. ,  CYJON, Rosa, L. ,  SIMHON, Elliot, D.

IPC: A61B05/055

CPC classification number: A61K49/06 ,  C07F9/6515 ,  C07F9/6524 ,  Y10T436/24

Abstract: Ligands with three of more nitrogen atoms incorporated into a linear or cyclic backbone structure, with the nitrogen atoms substituted with a combination of phosphonate groups and non-phosphonates groups, of which at least two are phosphonate groups, are disclosed. These ligands are combined with paramagnetic metal cations and administered in the form of pharmacologically acceptable salts, are useful as MRI contrast enhancement agents, which tend to localize in bone tissue without being conjugated to bone-specific biomolecules. Triazacyclononanes and tetraazacyclododecanes, with dihydroxyphosphorylmethyl or dihydroxyphosphorylethyl groups linked to the backbone nitrogens are preferred.

Abstract translation: 公开了具有三个以上氮原子并入线性或环状主链结构的配体，其中氮原子被膦酸酯基团和非膦酸酯基团的组合取代，其中至少两个是膦酸酯基团。 这些配体与顺磁金属阳离子结合并以药理学上可接受的盐的形式施用，可用作MRI对比增强剂，其倾向于定位在骨组织中而不与骨特异性生物分子缀合。 三氮杂环壬烷和四氮杂环十二烷与与骨架氮连接的二羟基磷酰基甲基或二羟基磷酰基乙基是优选的。

公开(公告)号：WO1994027498A1

公开(公告)日：1994-12-08

申请号：PCT/US1994005597

申请日：1994-05-19

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BRASCH, Robert, C. ,  MANN, Jefrey, S. ,  NITECKI, Danute, E.

Inventor： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

IPC: A61B05/055

CPC classification number: A61K49/128 ,  A61K49/085 ,  G01R33/281

Abstract: A macromolecular contrast agent for magnetic resonance imaging of the vascular system is constructed of a polymeric backbone structure with a plurality of spacer arms bonded to the backbone structure, each spacer arm terminating in at least one paramagnetic complex. The polymeric backbone thus serves as an amplifier by supporting a multitude of paramagnetic complexes, and the spacer arms contribute to the molecular weight. The spacer arms further contribute useful properties to the agent, such as hydrophilicity and the ability to cleave at a relatively rapid rate in blood.

Abstract translation: 用于血管系统的磁共振成像的大分子造影剂由聚合物骨架结构构成，其中多个间隔臂结合到骨架结构，每个间隔臂终止于至少一个顺磁络合物。 因此，聚合物骨架通过支撑许多顺磁络合物用作放大器，并且间隔臂有助于分子量。 间隔臂进一步为试剂提供有用的性质，例如亲水性和在血液中以相对较快速率裂解的能力。

公开(公告)号：WO1994012102A1

公开(公告)日：1994-06-09

申请号：PCT/US1993011383

申请日：1993-11-23

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  RHINEHART, Edward, J. ,  SPOHN, Michael, A.

IPC: A61B05/055

CPC classification number: G01R33/34084 ,  A61B2017/00557 ,  A61B2090/374

Abstract: An insertable intracavity probe (10) for use in magnetic resonance imaging of an area of interest in a relatively inaccessible region of the body is disclosed. The probe has an internal pickup coil (18) carried at the distal end of a shaft (12) for rectal insertion of the coil and an inflatable anti-migration cuff (72) to hold the probe in position and prevent outward migration thereof during a procedure. The anti-migration cuff (72) is carried on an outer sleeve (16) which is slidably and rotatably mounted on the shaft. The coil (18) is carried on a resilient tip structure (38) at the distal end of the shaft which is flexible in the plane normal to the plane of the coil. Deflection of the coil assembly is controlled by a pair of control lines (46 and 48) attached to the distal end of the tip structure. The lines may be selectively tensioned to deflect the coil in the direction of tension by a thumb wheel control (56) at the handle (26) of the probe.

Abstract translation: 公开了一种可插入腔内探针（10），用于在身体相对不可接近的区域中的感兴趣区域的磁共振成像。 该探头具有一个内部拾取线圈（18），该拾取线圈（18）承载在用于直线插入线圈的轴（12）的远端，以及一个可充气的反向移动箍（72），用于将探针保持在适当的位置，并防止在 程序。 反移动袖带（72）承载在可滑动地并可旋转地安装在轴上的外套筒（16）上。 线圈（18）承载在轴的远端处的弹性尖端结构（38）上，该顶端结构在垂直于线圈平面的平面中是柔性的。 线圈组件的偏转由附接到尖端结构的远端的一对控制线（46和48）控制。 可以选择性地张紧线以通过在探针的手柄（26）处的拇指轮控制（56）沿着张力方向偏转线圈。