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    Methods for modular synthesis of n-glycans and arrays thereof
    492.
    发明专利
    Methods for modular synthesis of n-glycans and arrays thereof 未知

    公开(公告)号：IL261517D0

    公开(公告)日：2018-10-31

    申请号：IL26151718

    申请日：2018-09-02

    Applicant: ACADEMIA SINICA

    IPC: C07H20060101

    Abstract: The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycans and glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.

    Methods for modular synthesis of N-glycans and arrays thereof
    493.
    发明专利
    Methods for modular synthesis of N-glycans and arrays thereof 未知

    公开(公告)号：AU2017231749A1

    公开(公告)日：2018-09-20

    申请号：AU2017231749

    申请日：2017-03-08

    Applicant: WONG CHI HUEY ,  ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  SHIVATARE SACHIN S

    IPC: C08B37/00 ,  C12P19/04 ,  G01N33/50 ,  G01N33/532 ,  G01N33/68

    Abstract: The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycansand glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.

    ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED CANCER THERAPY
    498.
    发明专利
    ANTI-VEGFR2 HUMAN ANTIBODY FOR ANTI-ANGIOGENIC AND TARGETED CANCER THERAPY 未知

    公开(公告)号：SG11201707949XA

    公开(公告)日：2017-10-30

    申请号：SG11201707949X

    申请日：2016-04-12

    Applicant: ACADEMIA SINICA

    Inventor： WU HAN-CHUNG ,  LU RUEI-MIN ,  CHIU CHIUNG-YI ,  LIU I-JU ,  CHANG YU-LING

    IPC: C07K16/28

    Abstract: An isolated antibody or an antigen-binding fragment thereof having a specific binding affinity to an epitope located within the domain 1 or domain 3 of human vascular endothelial growth factor receptor 2 (VEGFR2; SEQ ID NO: 74) is disclosed. The epitope within the domain 3 of the VEGFR2 is located between amino acid residues 250 and 270 of SEQ ID NO: 74. Use of the antibody or antigen-binding fragment thereof in the manufacture of a medicament for inhibiting tumor growth, tumor angiogenesis, and/or inducing cancer cell cytotoxicity in a subject in need thereof is also disclosed. Also disclosed is a method of detecting the presence of VEGFR2 in a tumor vascular endothelial cell or a cancer cell in a biological sample.

    METHODS FOR MODULAR SYNTHESIS OF N-GLYCANS AND ARRAYS THEREOF
    500.
    发明专利
    METHODS FOR MODULAR SYNTHESIS OF N-GLYCANS AND ARRAYS THEREOF 未知

    公开(公告)号：CA3016170A1

    公开(公告)日：2017-09-14

    申请号：CA3016170

    申请日：2017-03-08

    Applicant: ACADEMIA SINICA

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  SHIVATARE SACHIN S

    IPC: C08B37/00 ,  C12P19/04 ,  G01N33/50 ,  G01N33/532 ,  G01N33/68

    Abstract: The present disclosure relates to novel modular methods for generating a diversity of N-glycans of high mannose, hybrid and complex types. The present disclosure also relates to exemplary arrays of the synthesized N-glycans spotted onto aluminium oxide coated slides. These arrays can be used to detect and analyze binding interactions between the synthesized N-glycans and glycan binding molecules, such as HIV-1 neutralizing antibodies. The present disclosure also relates to methods for identifying agents that bind to various types of molecules on the arrays and to defining the structural elements of the molecules on the arrays that bind to those agents. The arrays and methods provided herein may be used for general epitope identification, drug discovery and as analytical tools. The present disclosure also provides useful glycans and epitope determinants that are useful in detecting, diagnosing, recurrence monitoring and preventing pathological diseases such as HIV.

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