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公开(公告)号：KR1020120048724A
公开(公告)日：2012-05-16
申请号：KR1020100105854
申请日：2010-10-28
Applicant: 재단법인대구경북과학기술원
Abstract: PURPOSE: A hydrogel is provided to give stimulation reaction by including negative polymers and positive ions and to maintain gel persistence. CONSTITUTION: A hydrogel comprises a hydrophilic or amphipathic polymer including two or more of phosphate(PO4 ^2) groups and polyhydric cation corresponding with negative charged phosphate (PO4^2). The polyhydric cation is selected from low molecular weight compound or polycation including more than 2 cations selected from -NH3 and -N2(CH3)3, and positive charged metal ion having more than bivalent, and combinations thereof. The hydrogel additionally includes 0-20 parts by weight of additive selected from NaCl, CaCl2, NaCSN, PEG and a combination thereof based on 100.0 parts by weight of membranous polymers.
Abstract translation: 目的：提供水凝胶，通过包括负性聚合物和阳离子进行刺激反应并保持凝胶持久性。 构成：水凝胶包含亲水或两亲性聚合物，其包括磷酸盐（PO4）2基团和对应于负电荷磷酸盐（PO 4 -2）的多羟基阳离子）的两种或多种。 多羟基阳离子选自低分子化合物或聚阳离子，包括多于2个选自-NH 3和-N 2（CH 3）3的阳离子，以及具有多于二价的带正电荷的金属离子及其组合。 基于100.0重量份膜聚合物，水凝胶另外包含0-20重量份的选自NaCl，CaCl 2，NaCSN，PEG及其组合的添加剂。
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公开(公告)号：KR1020120048236A
公开(公告)日：2012-05-15
申请号：KR1020100109773
申请日：2010-11-05
Applicant: 재단법인대구경북과학기술원 , (재)한국안광학산업진흥원
CPC classification number: Y02P20/542 , C08B1/02 , C08B1/003 , C08B3/06 , C08B3/26
Abstract: PURPOSE: A manufacturing method of cellulose ester is provided to improve substitution efficiency of a substituent, by using ionic liquid/dimethyl sulfoxide co-solvent system, and to effectively controlling reactivity, by stabilizing viscosity of reaction system. CONSTITUTION: A manufacturing method of cellulose ester comprises: a step of preparing a first solution comprising cellulose dissolved into ionic liquid; a step of preparing a second solution comprising a cyclic ester based monomer dissolved into dimethyl sulfoxide; and a step of esterificating the cellulose through ring opening-graft polymerization of reactive solution which is formed by mixing the first solution and the second solution. The volume ratio of the ionic liquid to the dimethyl sulfoxide is 1:0.5 - 1:4.
Abstract translation: 目的：提供一种纤维素酯的制备方法，通过使用离子液体/二甲基亚砜共溶剂系统，通过稳定反应体系的粘度，有效控制反应性，提高取代基的取代效率。 构成：纤维素酯的制造方法包括：制备包含溶解在离子液体中的纤维素的第一溶液的步骤; 制备包含溶解在二甲基亚砜中的基于环酯的单体的第二溶液的步骤; 以及通过将第一溶液和第二溶液混合形成的反应性溶液的开环接枝聚合来使纤维素酯化的步骤。 离子液体与二甲基亚砜的体积比为1:0.5-1:4。
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公开(公告)号：KR1020110075223A
公开(公告)日：2011-07-06
申请号：KR1020090131608
申请日：2009-12-28
Applicant: 재단법인대구경북과학기술원
CPC classification number: C08B5/00 , C08F251/02
Abstract: PURPOSE: A method for manufacturing thermoplastic cellulose polyester is provided to prepare cellulose ester having various thermal characteristics satisfying heat resistance of end-products and environmental-friendliness. CONSTITUTION: A method for manufacturing thermoplastic cellulose polyester comprises the steps of: acetylating at least a part of a hydroxyl group of the cellulose in ionic liquid to form cellulose acetate; and consecutively performing the ring opening graft polymerization of cyclic ester to a residual hydroxyl group of the cellulose acetate without the separation of the cellulose acetate from the ionic liquid. The acetylation is performed so that the cellulose is 1.0 ~ 2.9 per glucose unit.
Abstract translation: 目的：提供一种制备热塑性纤维素聚酯的方法，以制备具有满足最终产品耐热性和环境友好性的各种热特性的纤维素酯。 构成：制造热塑性纤维素聚酯的方法包括以下步骤：在离子液体中乙酰化纤维素的至少一部分羟基以形成乙酸纤维素; 并且将环状酯的开环接枝聚合连续地进行到乙酸纤维素的残留羟基，而不会从离子液体中分离出乙酸纤维素。 进行乙酰化，使纤维素为每个葡萄糖单位1.0〜2.9。
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公开(公告)号：KR1020100051163A
公开(公告)日：2010-05-17
申请号：KR1020080110187
申请日：2008-11-07
Applicant: 재단법인대구경북과학기술원
Abstract: PURPOSE: A method for manufacturing a nanostructure for photodynamic therapy is provided to ensure dispersion stability and generation efficiency of singlet oxygen. CONSTITUTION: A nanostructure for photodynamic therapy contains titania(TiO_2) nanoparticles and photosensitizer adsorbed on the surface of titania nanoparticle. A polymer dispersing agent is adsorbed on the surface of titania nanoparticles. The polymer dispersing agent is selected from polymethacrylic acid sodium salt, glycol chitosan, polyvinyl alcohol, polyethyleneimine, and polyethylene glycol. The photosensitizer is a phthalocyanine derivative containing copper phthalocyanine, zinc phthalocyanine, and aluminum phthalocyanine, and a porphyrin derivative containing protoporphyrin IX, aminolevulinic acid, and hematoporphyrin. A method for manufacturing the nanostructure comprises: a step of preparing titania sol; a step of inputting polymer dispersing agent to the titania sol to adsorb on the titania surface; and a step of inputting the photosensitizer to titania sol.
Abstract translation: 目的：提供一种用于制造光动力学治疗纳米结构的方法，以确保单线态氧的分散稳定性和发生效率。 构成：用于光动力学治疗的纳米结构包含二氧化钛（TiO_2）纳米颗粒和吸附在二氧化钛纳米颗粒表面上的光敏剂。 聚合物分散剂被吸附在二氧化钛纳米颗粒的表面上。 聚合物分散剂选自聚甲基丙烯酸钠盐，乙二醇壳聚糖，聚乙烯醇，聚乙烯亚胺和聚乙二醇。 光敏剂是含有酞菁铜，酞菁锌和铝酞菁的酞菁衍生物和含有原卟啉IX，氨基乙酰丙酸和血卟啉的卟啉衍生物。 制造纳米结构体的方法包括：制备二氧化钛溶胶的步骤; 将聚合物分散剂输入到二氧化钛溶胶中以吸附在二氧化钛表面上的步骤; 以及将光敏剂输入二氧化钛溶胶的步骤。
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公开(公告)号：KR1020090064617A
公开(公告)日：2009-06-22
申请号：KR1020070131880
申请日：2007-12-17
Applicant: 재단법인대구경북과학기술원
CPC classification number: A61F2/02 , A61F2230/0091
Abstract: A method for manufacturing a biodegradable plastic/nanofiber complex support material neurogram pipe is provided to offer excellent shape stability which can obtain flexibility and an original inside diameter until neural tissues are recovered. Biodegradable plastic reinforcing materials(40) are inserted into a tube-type electrospinning collecting unit(10) having various sizes of diameters(11), so that the inserted biodegradable plastic reinforcing materials are fully contacted for mutual connection with the electrospinning collecting unit. A biodegradable high molecular solution is electrically radiated to the electrospinning collecting unit and the plastic reinforcing materials, which are coupled together, to manufacture nanofiber.
Abstract translation: 提供了一种制造可生物降解的塑料/纳米纤维复合物支撑材料神经图示管的方法，以提供优异的形状稳定性，其可以获得柔韧性和原始内径，直到神经组织被回收。 可生物降解的塑料增强材料（40）被插入到具有各种尺寸的直径（11）的管式静电收集单元（10）中，使得插入的可生物降解的塑料增强材料被完全接触以与静电纺丝收集单元相互连接。 将可生物降解的高分子溶液电辐射到电纺丝收集单元和耦合在一起的塑料增强材料以制造纳米纤维。
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Patent Agency Ranking
公开(公告)号：KR100835898B1
公开(公告)日：2008-06-09
申请号：KR1020060134580
申请日：2006-12-27
Applicant: 재단법인대구경북과학기술원
Abstract: Polyvinylalcohol hydrogel particles are provided to be amorphous irrespective of the degree of hydrolysis, to ensure relatively low specific gravity and increased surface unevenness, and to exhibit improved dispersibility in a contrast medium when the particles are used as an embolizing agent. Polyvinylalcohol hydrogel particles are prepared by dispersing poly(vinyl acetate) microspheres in an aqueous acid solution. The aqueous acid solution comprises 0.1-3 M of hydrochloric acid, 0.1-500 ml of alcohol, and 0.1-300 g of an inorganic salt, based on the aqueous acid solution 1L. The polyvinylalcohol hydrogel particle has an uneven surface. The alcohol is methanol or ethanol. The inorganic salt is sodium sulfate or sodium sulfite.
Abstract translation: 提供聚乙烯醇水凝胶颗粒为无定形程度的水解，以确保相对低的比重和增加的表面不均匀性，并且当该颗粒用作栓塞剂时，在造影剂中表现出改进的分散性。 通过将聚（乙酸乙烯酯）微球分散在酸性水溶液中制备聚乙烯醇水凝胶颗粒。 酸水溶液包含0.1-3M盐酸，0.1-500ml醇和0.1-300g无水盐，基于1L酸水溶液。 聚乙烯醇水凝胶颗粒具有不均匀的表面。 醇是甲醇或乙醇。 无机盐是硫酸钠或亚硫酸钠。
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公开(公告)号：KR101820494B1
公开(公告)日：2018-01-19
申请号：KR1020170030021
申请日：2017-03-09
Applicant: 재단법인대구경북과학기술원
IPC: C08G69/42 , C08G69/04 , A61K47/34 , A61K31/337 , A61K31/704 , A61K31/282 , A61K31/138
Abstract: 본발명은양친매성멀티제미니고분자, 이를포함하는약물전달체, 이의제조방법및 양친매성멀티제미니고분자조성물에관한것으로서, 좀더 구체적으로설명하면, 이황화결합(-S-S-)을포함하는양친매성멀티제미니고분자를약물전달체로사용함으로써, 약물전달체내 약물이타켓세포에흡수된후 신속하게마이셀분열이이루어져약물이타겟세포에흡수되는속도를향상시킬수 있는발명에관한것이다.
Abstract translation: 本发明两亲多双子聚合物，药物递送系统，制造方法，其包括相同的，并且所述两亲多双子涉及一种聚合物组合物，更具体地，两亲多双子含聚合物的二硫键（-SS-） 一个是作为药物载体，药物递送使用，包括一个主体的药物迅速地在靶细胞的吸收根据可以提高吸收速度在靶细胞中的本发明所述药物后胶束裂解。
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公开(公告)号：KR101761692B1
公开(公告)日：2017-08-04
申请号：KR1020160157661
申请日：2016-11-07
Applicant: 재단법인대구경북과학기술원
IPC: C08G75/0236 , A61K47/30 , A61K9/127 , A61K31/337 , A61K31/704 , A61K31/138 , C08G65/333 , C08G65/334
CPC classification number: C08G75/0236 , A61K9/1273 , A61K31/138 , A61K31/337 , A61K31/704 , A61K47/30 , C08G65/333 , C08G65/334
Abstract: 본발명에따른양친매성제미니고분자화합물은친수성부위와소수성부위를동시에가지고있으며미셀구조를이룰수 있다. 이러한미셀구조를통해소수성약물을봉입할수 있는약물전달체로사용될수 있으며, 특히본 발명에따른양친매성제미니고분자화합물을함유한약물전달체는디설파이드결합의티올반응성으로인해, 특정부위에서의약물전달및 방출특성을크게향상시킬수 있다.
Abstract translation: 根据本发明的两亲性双子聚合物具有亲水部分和疏水部分两者并且可以实现胶束结构。 具体而言，由于二硫键的巯基反应性，含有根据本发明的两亲性双子聚合物的药物递送系统可以在特定位点呈现药物递送和释放特征， 可以大大改善。
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